The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults

Table 2 Estimates from grid search for identifying the optimal number of latent subgroups corresponding to the MMSE trajectories in the ADNI (n = 1310, observations = 6864)

Model	Subgroup number	BIC	Log Likelihood	Class 1 (%)	Class 2 (%)	Class 3 (%)	Class 4 (%)	Class 5 (%)
Model 1	1	56423.77	-28190.35	100.00
Model 2	2	56179.07	-28053.64	37.56	62.44
Model 3	3	56157.25	-28028.38	41.45	21.52	37.03
Model 4	4	56179.01	-28024.91	24.66	20.38	36.18	18.78
Model 5	5	56194.52	-28018.30	23.89	19.09	5.50	27.63	23.89

Note. Models were fitted with an increasing number of classes in ascending order (1–5 classes). BIC: Bayesian Information Criterion. The bold font represents the estimates of the best subclass model determined by the lowest BIC. Posterior class probabilities for belonging to each class for the respective models are also provided

ISSN: 1471-2377