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Table 3 Results from the multivariate latent class mixed models showing the association of rs6859 and other predictors on the trajectory of the identified 3 latent groups (n = 1310, observations = 6864)

From: The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults

Variable

Coefficient

95% CI

p-value

rs6859 (class1)

-2.28

-4.05, -0.50

< 0.05*

rs6859 (class2)

-5.56

-9.61, -1.51

< 0.01**

rs6859 (class3)

-0.37

-1.62, 0.87

0.55

Age

-0.42

-1.21, 0.36

0.29

Gender (Male)

-2.92

-4.37, -1.47

< 0.001***

Education

2.79

2.09, 3.49

< 0.001***

Race (White)

4.16

1.25, 7.08

< 0.01**

Visit

-1.62

-1.78, -1.46

< 0.001***

Smoking (Yes)

-0.83

-2.35, 0.69

0.28

Dyslipidemia (Yes)

0.61

-0.88, 2.12

0.42

Hypertension (Yes)

-0.23

-2.13, 1.65

0.80

Diabetes (Yes)

1.48

-0.92, 3.89

0.22

CVD (Yes)

1.05

-0.79, 2.91

0.26

  1. Note. *p < 0.05; **p < 0.01; ***p < 0.001