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Fig. 5 | BMC Neurology

Fig. 5

From: Exploring the role of mitochondrial-associated and peripheral neuropathy genes in the pathogenesis of diabetic peripheral neuropathy

Fig. 5

Most significantly enriched Hallmark gene sets related to the class distinction. HSPA5 exhibited significant negative correlations in A interferon alpha response and interferon gamma response, and B Wnt beta-catenin signaling. LRRK2 exhibited significant positive correlations in C interferon alpha response and D interferon gamma response. MRPL22 showed a significant positive correlation with E oxidative phosphorylation. MARS gene displayed a significant negative correlation with F TNFA signaling via NFKB. The score at the peak of the plot (the score furthest from 0) is the ES for the overall gene set. The middle portion of the plot shows where the members of the gene set appear in the ranked list of genes. The bottom portion of the plot shows the value of the ranking metric as the list of ranked genes decreases in value. The ranking metric measures an individual gene’s correlation between its expression and the related to the phenotypes (expression level group)

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BMC Neurology

ISSN: 1471-2377

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