Table 1 Comparison of variables between the sWMH and mWMH groups

Age (years)

67.00(58.00,73.00)

61.00(54.00,68.00)

< 0.001

0.069

BMI (kg/m²)

24.48 ± 3.35

24.38 ± 3.56

0.422

0.103

Gender, male, n (%)

72(64.8%)

93(63.7%)

0.950

Hypertension, n (%)

83(74.8%)

96(65.8%)

0.155

Diabetes, n (%)

40(36.0%)

42(28.8%)

0.269

Smoking, n (%)

45(40.5%)

68(46.6%)

0.354

Alcoholism, n (%)

33(29.7%)

48(32.9%)

0.738

Lymphocyte (* 10⁹/L)

1.69 ± 0.48

1.96 ± 0.0.65

< 0.001

0.455

Neutrophil (* 10⁹/L)

3.86(3.30,4.31)

3.45(2.60,4.51)

0.029

0.201

Platelet (* 10⁹/L)

203.0 ± 48.64

210.0 ± 55.89

0.669

0.067

NLR

2.34(1.85,3.07)

1.86(1.45,2.46)

< 0.001

0.349

MLR

0.27(0.23,0.34)

0.24(0.21,0.31)

0.003

0.350

PLR

126.31 ± 46.65

119.02 ± 44.64

0.006

0.310

SII

475.58(359.18,585.93)

350.30(291.27,522.41)

< 0.001

0.285

SIRI

1.03(0.80,1.39)

0.85(0.59,1.28)

< 0.001

0.319

WBC (* 10⁹/L)

6.32(5.44,7.24)

6.30(4.91,7.73)

0.430

0.065

GFR (mL/min)

91.37 ± 19.74

99.50 ± 25.30

0.009

0.347

TG (mmol/L)

1.25(0.97,1.91)

1.37(0.99,2.04)

0.147

0.182

TC (mmol/L)

4.20(3.70,4.85)

4.41(3.62,5.14)

0.238

0.110

HDL-C (mmol/L)

1.22(1.08,1.52)

1.19(1.01,1.45)

0.360

0.112

LDL-C (mmol/L)

2.64 ± 0.91

2.56 ± 0.89

0.238

0.008

LDL-C/HDL-C

2.06 ± 0.80

2.24 ± 0.98

0.133

0.121

lipoprotein(a)

177.00(96.50,323.00)

137.00(72.50,279.00)

0.048

0.225

Fasting glucose (mmol/L)

5.38(4.73,6.35)

5.09(4.71,5.79)

0.075

0.155

Transferrin saturation, %

30.28 ± 12.35

34.74 ± 10.22

0.275

0.171

Serum iron (µmol/L)

15.44 ± 6.80

18.08 ± 4.89

< 0.001

0.511

MoCA, score

23.00(21.00,24.50)

25.00(21.50,27.00)

< 0.001

0.811

AVLT, score

12.72 ± 5.32

16.60 ± 5.70

< 0.001

0.706

SDMT, score

23.17 ± 10.34

32.89 ± 12.75

< 0.001

0.825

SCWT, score

106.14 ± 38.58

85.0 ± 29.32

< 0.001

0.625

DST (inverted order)

4.00(3.50,7.00)

6.00(4.00,8.00)

< 0.001

0.581