Table 3 Association of treatment changes with clinical and demographic variables according to univariable and multivariable Cox proportional hazard models

Sex ^a

0.98

0.84–1.15

0.8

0.81

0.68–0.96

0.017

Phenotype ^b

1.04

0.87–1.24

0.7

1.17

0.96–1.42

0.13

Disease duration ^c

0.96

0.95–0.97

 < 0.001

0.94

0.93–0.95

 < 0.001

Age at MS onset ^d

0.99

0.98–1.00

0.004

0.99

0.98–0.99

 < 0.001

Insurer ^e

0.71

0.61–0.83

 < 0.001

0.67

0.57–0.79

 < 0.001

HUN ^f

2.50

2.13–2.92

 < 0.001

1.77

1.49–2.10

 < 0.001

Diagnostic delay ^g

0.97

0.95–1.00

0.015

0.99

0.97–1.01

0.5