From: Migraine treatment: quo vadis? Real-world data study (2015–2022) in Spain
Characteristics | Patients diagnosed with migraine (n = 61,204) | Patients diagnosed with migraine on treatment (n = 30,982) | General population (n = 1,112,135) | Age and gender adjusted sample of the general population (n = 100,002) |
---|---|---|---|---|
Gender, n (%) | ||||
Female | 47,585 (77.7) | 25,177 (81.3)*** | 577,197 (51.9) | 77,750 (77.7) |
Male | 13,618 (22.3) | 5,804 (18.7)*** | 534,937 (48.1) | 22,251 (22.3) |
Age, n (%) | ||||
Female | ||||
< 12 years old | 66 (0.1) | 42 (0.2)*** | 54,833 (9.5) | 108 (0.1) |
12–18 years old | 778 (1.6) | 481 (1.9)*** | 38,672 (6.7) | 1,271 (1.6) |
19–29 years old | 4,463 (9.4) | 2,314 (9.2)*** | 68,109 (11.8) | 7,293 (9.4) |
30–39 years old | 7,826 (16.4) | 4,031 (16)*** | 79,653 (13.8) | 12,788 (16.4) |
40–49 years old | 11,630 (24.4) | 6,636 (26.4)*** | 94,083 (16.3) | 19,002 (24.4) |
50–59 years old | 10,715 (22.5) | 6,062 (24.1)*** | 84,847 (14.7) | 17,507 (22.5) |
≥ 60 years old | 12,104 (25.4) | 5,609 (22.3)*** | 156,997 (27.2) | 19,777 (25.4) |
Male | ||||
< 12 years old | 58 (0.4) | 39 (0.7) | 58,307 (10.9) | 96 (0.4) |
12–18 years old | 486 (3.6) | 247 (4.3) | 40,120 (7.5) | 794 (3.6) |
19–29 years old | 1,642 (12.1) | 585 (10.1) | 62,587 (11.7) | 2,684 (12.1) |
30–39 years old | 2,171 (15.9) | 871 (15) | 71,146 (13.3) | 3,548 (15.9) |
40–49 years old | 3,234 (23.8) | 1,462 (25.2) | 92,009 (17.2) | 5,285 (23.8) |
50–59 years old | 2,863 (21) | 1,340 (23.1) | 81,310 (15.2) | 4,678 (21) |
≥ 60 years old | 3,160 (23.2) | 1,257 (21.7) | 129,455 (24.2) | 5,163 (23.2) |
Comorbidities, n (%) | ||||
Cardiovascular | 14,995 (24.5)*** | 7,250 (23.4)*** | 222,427 (20) | 21,673 (21.7) |
Acute pulmonary heart diseases | 184 (0.3) | 93 (0.3) | 3,336 (0.3) | 339 (0.3) |
Chronic cardiac rheumatic disease | 184 (0.3) | 94 (0.3) | 3,558 (0.3) | 353 (0.4) |
Arterial hypertension | 11,629 (19)*** | 5,670 (18.3)*** | 173,492 (15.6) | 17,025 (17) |
Ischemic disease (AMI/AP) | 1,408 (2.3) | 527 (1.7)*** | 28,915 (2.6) | 2,197 (2.2) |
Other CV diseases | 3,856 (6.3)*** | 1,673 (5,0.4) | 62,279 (5.6) | 5,678 (5.7) |
Peripheral CV Disease | 1,346 (2.2)*** | 651 (2.1)*** | 18,906 (1.7) | 1,745 (1.7) |
Stroke | 1,653 (2.7)*** | 806 (2.6)*** | 23,021 (2.1) | 2,063 (2.1) |
Digestive | 15,546 (25.4)*** | 8,582 (27.7)*** | 164,596 (14.8) | 16,783 (16.8) |
Gastrointestinal diseases 1b | 11,323 (18.5)*** | 6,506 (21)*** | 108,989 (9.8) | 12,191 (12.2) |
Gastrointestinal diseases 2c | 5,692 (9.3)*** | 2,881 (9.3)*** | 66,727 (6) | 5,943 (5.9) |
Metabolic | 23,625 (38.6)*** | 11,866 (38.3)*** | 311,397 (28) | 33,079 (33.1) |
Dyslipidaemia | 15,668 (25.6)*** | 7,807 (25.2)*** | 212,417 (19.1) | 21,787 (21.8) |
Obesity | 7,773 (12.7) *** | 3,873 (12.5)*** | 96,755 (8.7) | 10,372 (10.4) |
Diabetes (Type 1 / Type 2) | 4,407 (7.2)*** | 1,983 (6.4)*** | 84,522 (7.6) | 7,690 (7.7) |
Hypothyroidism | 4,774 (7.8)*** | 2,510 (8.1)*** | 44,485 (4) | 6,342 (6.3) |
Neurologic | 796 (1.3)*** | 434 (1.4)*** | 10,009 (0.9) | 923 (0.9) |
Epilepsy | 796 (1.3)*** | 434 (1.4)*** | 10,009 (0.9) | 923 (0.9) |
Neuropsychiatric | 21,421 (35)*** | 12,703 (41)*** | 180,165 (16.2) | 21,881 (21.9) |
Anxiety, Dissociative and Somatoform Disorders | 17,198 (28.1)*** | 9,666 (31.2)*** | 144,537 (13) | 18,229 (18.2) |
Bipolar Disorder | 734 (1.2)*** | 434 (1.4)*** | 6,672 (0.6) | 800 (0.8) |
Depression | 3,489 (5.7)*** | 2,014 (6.5)*** | 30,027 (2.7) | 3,701 (3.7) |
Drug abuse | 122 (0.2)*** | 62 (0.2)*** | 1,111 (0.1) | 97 (0.1) |
Drug dependency | 190 (0.3)*** | 93 (0.3)*** | 2,223 (0.2) | 181 (0.2) |
Other syndromes | 3,795 (6.2)*** | 3,563 (11.5)*** | 15,569 (1.4) | 2,119 (2.1) |
Stress syndromes | 61 (0.1)* | 31 (0.1) | 1,118 (0.1) | 68 (0.1) |
ADHD | 245 (0.4)*** | 155 (0.5)*** | 6,672 (0.6) | 213 (0.2) |
Pain | 31,092 (50.8)*** | 16,482 (53.2)*** | 324,743 (29.2) | 37,466 (37.5) |
Chronic Pain, Fibromyalgia, Generalised Pain | 5,202 (8.5)*** | 2,912 (9.4)*** | 50,046 (4.5) | 5,794 (5.8) |
Dorsopathies | 23,441 (38.3)*** | 12,672 (40.9)*** | 227,987 (20.5) | 26,836 (26.8) |
Chronic Fatigue Syndrome | 6 (0) | 3 (0) | 222 (0) | 3 (0) |
Disorders of the peripheral nervous system | 7,222 (11.8)*** | 3,904 (12.6)*** | 58,942 (5.3) | 7,195 (7.2) |
Osteoarthrosis and related disorders | 7,528 (12.3)*** | 3,532 (11.4)*** | 87,858 (7.9) | 10,101 (10.1) |
Temporomandibular joint disorders | 612 (1)*** | 341 (1.1)*** | 4,448 (0.4) | 539 (0.5) |
Respiratory | 7,228 (11.8)*** | 3,718 (12)*** | 83,410 (7.5) | 7,937 (7.9) |
Asthma / COPD | 6,365 (10.4)*** | 3,315 (10.7)*** | 77,849 (7) | 7,265 (7.3) |
Sinusitis | 979 (1.6)*** | 527 (1.7)*** | 6,672 (0.6) | 797 (0.8) |
Rheumatologic | 490 (0.8)* | 248 (0.8) | 5,560 (0.5) | 695 (0.7) |
Arthritis | 490 (0.8)* | 248 (0.8) | 5,560 (0.5) | 695 (0.7) |
Sleep | 6,916 (11.3)*** | 3,966 (12.8)*** | 67,840 (6.1) | 7,704 (7.7) |