An observational time-series study on the behavioral effects of adjunctive artisanal cannabidiol use by adults with treatment resistant epilepsies

Table 3 Missing data analyses: imputed data analysis

Multiple Imputation datasets: QOLIE-31-P, HADS, LAEP
Imputation dataset ^#	N	F statistic	P value	Partial ETA Squared
QOLIE-31-P: 1-Way Repeated Measures ANOVA with factor of TIME (3 levels): (Greenhouse-Geisser corrected for sphericity violation)
Original complete case dataset	10	8.042	.003^*	.472
1	17	8.850	<.001^*	.356
2	17	5.087	.012 (.021)^*	.241
3	17	13.858	<.001 (.001)^*	.464
4	17	8.371	.001 (.003)^*	.343
5	17	3.553	.04 (.058)	.182
HADS: 2-Way Repeated Measures ANOVA with factors of TIME (3 levels) and SUBSCALE (2 levels)
Original complete case dataset	10	5.616	.013^*	.384
1	17	7.972	.002^*	.333
2	17	8.174	.001^*	.338
3	17	2.048	.146	.113
4	17	3.010	.063	.158
5	17	6.755	.004^*	.297
LAEP: 1-Way Repeated Measures ANOVA with factor of TIME (3 levels)
Original complete case dataset	10	13.936	<.001^*	.608
1	17	21.973	<.001^*	.579
2	17	1.062	.357	.062
3	17	6.975	.003^*	.304
4	17	13.647	<.001 (.001)^*	.460
5	17	14.845	<.001^*	.481

(top) shows the results of one-way repeated measures ANOVAS with a factor of TIME (3 levels) for five imputed datasets for the QOLIE-31-P, along with the original complete case results. Table 2 (middle) shows the results of two-way repeated measures ANOVA for the HADS with factors of TIME (3 levels) and SUBSCALE (2 levels) for five imputed datasets, along with the original complete case results. Table 2 (bottom) shows the results of one-way repeated measures ANOVA with a factor of TIME (3 levels) for five imputed datasets for the LAEP, along with the original complete case results
^* = p<0.05
^# = imputed dataset number

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