Evaluation of an electronic diary for improvement of adherence to interferon beta-1b in patients with multiple sclerosis: design and baseline results of an observational cohort study
© Zettl et al.; licensee BioMed Central Ltd. 2013
Received: 10 May 2013
Accepted: 21 August 2013
Published: 6 September 2013
Multiple sclerosis is a chronic, incurable, demyelinating disease that requires long-term treatment. Rates of non-adherence to prescribed therapy of up to 50% have been reported for chronic diseases. Strategies to improve treatment adherence are therefore of the utmost importance. This study will evaluate the effect of using electronic and paper diaries on treatment adherence to interferon beta-1b in patients with a first clinical isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS). Here we report on the study design and results of baseline assessments.
Patients were recruited into a prospective national multicenter cohort study for an observational period of 2 years. At the start of the study, patients opted to use a digital (DiD) or paper diary (PD) to document self-administered injections of interferon beta-1b. Adherence to treatment will be assessed on the dropout rate at the end of the observation period and on the regularity of injections every other day at 6-month intervals. Patient-related health outcomes will also be evaluated.
700 patients with a mean age of 38.3 (SD 10.3) years and a mean duration of disease since diagnosis of 3.6 (SD 5.9) years were enrolled. 383 patients opted for the digital diary, 192 of which included an injection reminder. Significantly more male than female patients opted for the DiD. Only gender was identified as a factor influencing the decision for DiD or PD. Based on rating scales, a significantly higher proportion of women had depressive comorbidities at baseline.
Demographic characteristics of the two cohorts were similar at baseline. More women chose a paper diary, and more had depression at baseline. These imbalances will be addressed in the analysis of the study as possible confounders influencing long-term treatment adherence in the digital and paper diary cohorts.
ClinicalTrials.gov Identifier: NCT00902135.
KeywordsAdherence Interferon beta-1b Non-interventional study Electronic diary Multiple sclerosis Immunomodulation
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system resulting in functional deficits due to demyelination and axonal degeneration. Disease-modifying drugs (DMD) such as interferon (IFN) beta or glatiramer acetate are the current drugs of choice for the first-line treatment of MS. As a chronic disease, MS requires long-term treatment, hence close adherence to prescribed therapy is a prerequisite for long-term benefit. Among people with chronic diseases, low adherence rates to long-term medication are a common problem, and non-adherence rates of up to 50% on average have been estimated by the World Health Organization depending on the disorder [1, 2].
As a consequence, enormous costs for healthcare systems may be created by poor adherence because of relapses, prolonged duration of disease states, hospital admissions, early retirement, and secondary diseases [3, 4]. Non-adherence rates for MS vary between 6 and 43% depending on factors such as type of study, definition of non-adherence, type of DMD and individual disease state [5, 6]. Non-adherence of MS patients to their DMD may be defined as either termination of therapy or interruption of regular administration. Treatment adherence is influenced by a variety of factors, including factors related to the MS centre or the patient’s clinical condition, side effects, involvement in treatment decisions or way of coping . Recent studies revealed that besides physical and psychological factors, depression, pain from injection, skin reactions and patient- and physician-related factors may affect adherence to medication [5, 7]. Tremlett et al. identified lower education levels, increased alcohol consumption, and history of missed doses as further factors that reduce adherence .
The current DMDs have to be administered regularly following strict injection schedules. Missing one or more doses over a given period has been used as a definition for non-adherence [9, 10]. Missing a single injection usually has no clinical relevance. Interruption of DMD treatment, however, may result in loss of efficacy and decreased treatment benefit . Improvement and maintenance of adherence to DMDs is therefore of great importance in ensuring a positive influence on the course of disease in MS patients. This means that interventions intended to enhance medication adherence have to cover different aspects to achieve overall effectiveness, such as providing the patient with detailed information on treatment, realistic treatment expectations, convenient care, crisis intervention, optimized support by nursing services, and counselling [11, 12].
One of the most frequent reasons for missing injections is simply forgetting to administer the medication [8, 10, 13, 14]. Thus, measures that regularly remind the patient to administer the medication may help to improve adherence, and ultimately clinical outcome. The use of an electronic diary may be a way to address this problem. The use of electronic diaries is well established in conditions such as haemophilia and migraine [15–17], but they are not yet in widespread use by MS patients. They are also a reliable means of supporting self-monitoring, documentation of relevant symptoms or side effects, and documenting and assisting disease management.
The goal of the study described here – the “Betaferon® injection management: Non-interventional study on PDA-supported effects on Adherence to long-term injection Therapy (BETAPATH)” study – is to compare treatment adherence to IFN beta-1b (Betaferon®) in CIS- and RRMS patients under daily-life treatment conditions using a paper diary (PD) or an electronic diary in the form of a Personal Digital Assistant (PDA, or digital diary [DiD]) with and without a reminder function. Here we report on the design of this study and the findings of baseline assessments.
Adult RRMS and CIS outpatients aged at least 18 years who had completed initial dose titration or started treatment with IFN beta-1b no longer than 3 months earlier were invited to participate. Patients were not invited to take part in the study until the decision had been taken to start them on IFN beta-1b.
The physician or nurse responsible explained to the patient how to use the DiD. A hotline for questions was also available. The DiD is a commercially available Smartphone with all standard and cost functions blocked (Figure 2). Half of the devices are equipped with an injection reminder. Devices with and without the reminder function were randomly allocated. All DiDs provide an injection scheme and document the injection history. They also make suggestions for suitable injection sites for upcoming injections, and have a diary and a help function with information on the administration of IFN beta-1b. Other injection-relevant details can also be recorded, such as side effects. The user records every injection with the date on the DiD. All entries are transmitted online to a central database maintained by an external service provider. Legal requirements with respect to confidentiality of patient data are guaranteed.
FU visit 1
FU visit 2
FU visit 3
Patient information and informed consent
Neurological history, clinical events, disease course
MRI findings if available
Cognitive status, PASAT
Fatigue Scale (WEIMuS)
Treatment Support Questionnaire
The primary outcome measure of adherence to the therapy with IFN beta-1b is overall continuity of treatment. All patients who discontinue treatment before week 104 for any reason specified in the case report form (CRF) e.g. an adverse event, withdrawal of informed consent, loss to follow-up, are classed as dropouts.
The secondary outcome measure of treatment adherence is the overall regularity of IFN beta-1b injections in relation to the prescribed ‘every other day’ schedule. Subjects are considered adherent to the injection schedule if they do not miss more than 5 injections every 6 months over the 2-year period. Dropouts are considered adherent to the injection schedule if they are treated for at least 6 months and are adherent to the injection schedule up to their last visit in this non-interventional study (NIS). For patients who dropped out for reasons not related to adherence, e.g. loss to follow-up, death, closure of site, termination of study, adherence is assessed up to the time of the event, even if it occurs before the completion of 6 months in the study.
Other secondary outcome measures include adherence for each 6-month interval, dropout rates by dropout reason, patient satisfaction and tolerability, also with regard to the injection devices used, and clinical course, e.g. relapse rate, grade of disability. Patient-related health outcomes such as depression, cognition, fatigue and quality of life are also assessed. Safety-related variables consist of a general tolerability assessment by the physician and reports of adverse events with an assessment of causal relationship, seriousness, action taken, and outcome.
Throughout the study, patient-reported outcomes are documented by the following rating scales FAMS (Functional Assessment in MS , higher scores = better outcome), CES-D (Center of Epidemiologic Studies Depression Scale [19–21], higher score = more depressiveness), WEIMuS (Würzburger Erschöpfungsinventar bei MS , higher score = more fatigue), EQ5-D (EuroQuol-5D Health State , higher score = better quality of life) and EDSS (Expanded Disability Status Scale , higher score = more disability).
Descriptive analysis of the data was performed using summary statistics for categorical and quantitative (continuous) data. Continuous data were described by number of non-missing values, mean, standard deviation, minimum, median and maximum. Categorical data, including categories of continuous data, are presented in frequency tables.
Significance calculations were performed based on t-tests for continuous variables, and on χ2-tests or (if possible) exact Fisher tests for categorical variables. As the analyses are exploratory, significant p-values <0.05 should be interpreted as exploratory results. As BETAPATH is a NIS and analyses are based on an interim database, missing values may appear for all variables analysed and percentages for categorical variables may therefore not add up to 100%.
Between May 2009 and December 2011, 700 patients (496 women [70.9%] and 201 men [28.7%]; 3: sex missing) with CIS (35) or RRMS (662, 3 missing) were enrolled at 164 sites and had baseline documentation. Of these, 317 are using a PD and the remaining 383 are using a DiD (192 with reminder function, 191 without).
No. of patients
Age [years] - mean (SD)
Body weight [kg] - mean (SD)
Men - n (%)
Women - n (%)
Diagnosis [years] before - mean (SD)
Relapse rate last two years - mean (SD)
EDSS - mean (SD)
Diagnosis CIS - n (%)
Diagnosis RRMS - n (%)
Living with partner - n (%)
Living alone - n (%)
- Elementary school - n (%)
- Secondary school - n (%)
- High school - n (%)
- University - n (%)
Age of study cohorts by previous DMD treatment
age [years] - mean (SD)
age [years] - mean (SD)
The duration of disease in the pretreated group was longer: MS was diagnosed 7.1 years (SD 6.4) before enrolment, compared to 2.2 years (SD 5.0) in the treatment-naïve group. More than 60% of the patients had a history of MS of less than 2 years, which is reflected in the high proportion of patients without DMD pretreatment. The mean EDSS score for all patients enrolled was 2.0 (SD 1.4), with no difference between the PD and DiD groups.
Results of patient-reported outcomes of rating scales
Rating scale score
FAMS total score
WEIMus total score
Grouped CES-D total score at baseline
EQ-5D Health State: anxiety/depression
Not anxious or depressed
Moderately anxious or depressed
Extremely anxious or depressed
Despite many attempts to improve and facilitate the administration of DMDs for MS patients, e.g. by assistance from a special MS nurse and auto-injectors, non-adherence to a prescribed therapy and treatment schedule is still a problem for the long-term treatment of MS patients. The study described here is evaluating the influence of a digital diary (with and without a reminder function) on treatment adherence to IFN beta-1b in routine clinical practice. In keeping with the non-interventional nature of the study, patients decided themselves whether to use a digital or paper diary to record treatment administration. Careful comparison of baseline characteristics of both study cohorts will therefore be necessary before analysis of adherence rates. This will allow for identification and consideration of possible confounding factors. A special feature of our study is the randomized distribution of the DiDs with and without a reminder function. This design will allow the direct assessment of effects of the reminder function on the overall dropout rate and the regularity of the injection schedule by comparing the findings in the two study cohorts. Thus, the present study may result in a further option in addition to the approaches using injection devices and nurse support services discussed recently .
Our study is a prospective trial with an observation period of up to two years and a study population of 700 patients. It is one of the largest single studies focusing on long-term treatment adherence in MS using a digital diary. Findings for the characteristics of the study population at baseline have already been evaluated. Demographic and baseline findings for educational level, living status, duration of disease since start of symptoms, number of relapses, EDSS, impairment of upper extremities, visual impairment, and cognitive assessment did not differ between the groups using the digital diary (DiD) and the paper diary (PD). An imbalance in gender distribution was, however, found showing that male gender was significantly associated with usage of the DiD, as well as younger age. We found nothing in the literature to support a greater preference amongst men for technical devices, and the demographics of our study population do not explain this gender effect. Several studies have focused on gender differences in the use of computers in general , and one study on the use of patient’s electronic personal health records by physicians . These studies showed that women are less willing to use computers and that female physicians are less willing to use electronic tools.
Analysis of psychometric test results at baseline revealed no difference between the study cohorts for fatigue measured on the WEIMuS scale or for health-related quality of life assessed on the VAS of the EQ-5D. The mean scores on the WEIMuS scale of around 20 (maximum 68) are similar to values obtained in healthy control persons , and hence indicate a low level of fatigue. In line with this, values obtained on the EQ-5D-VAS of approximately 74 (maximum 100) indicate a high mean quality of life amongst the study population. This is further supported by the mean total scores obtained on the FAMS rating scale of 129 and 134 for the PD and DiD groups respectively (maximum 176). Taken together, these results suggest that a majority of patients enjoy a high degree of health-related quality of life, which may be related to age and the relatively short time since diagnosis of MS of the study population.
Higher values for the PD group were found for the scores on EQ-5D health state anxiety subscale and the CES-D depression rating scale. When the total study cohort was stratified by gender a higher degree of depressive symptoms was found in women. However, after further stratification of the gender cohorts into DiD and PD subgroups the CES-D total score was no longer higher in the PD group suggesting that the association of depression and preference for PD usage can mainly be explained by female gender and not by severity of depression. The mean CES-D total scores for the whole study population and for men and women ranged between 10.8 and 14.2, and were therefore below the cut-off of 15, below which no relevant depressive comorbidities are expected. About 32% of the total study population, however, had a CES-D total score of ≥ 16, suggesting that a substantial part of these patients will show some depressive morbidity during the study . This result is in line with previous evaluations using the CES-D in male and female MS patients , but much lower than in an epidemiological study of a large community sample in which 42% of the cohort had clinically significant symptoms . However, the patients in the latter study had a much higher mean age (49.3 years) and a much longer mean duration of illness (12.5 years). Correspondingly, the mean disability status of this cohort was higher than in the present population (5.6 for women and 6.1 for men vs 2.0). Since the severity of illness as reflected by the grade of disability has been identified as the greatest factor associated with depressive symptoms , this might be an explanation for the different ratios of depressed and non-depressed subjects.
The findings presented here show an association between depressive symptoms and female gender. This is not surprising, as depression is about twice as common in women than in men in the general population . It has been shown that patients with symptoms of depression are more likely to discontinue their DMD and that suitable treatment of their depression may increase adherence .
Amongst a large sample of MS patients enrolled into the non-interventional BETAPATH study, half of the women and two-thirds of the men chose to document their treatment using an electronic diary and the remainder chose a traditional paper diary. Demographic characteristics of the two cohorts were similar at baseline, except with regard to gender, which emerged as the main distinguishing factor. A further potential confounder was depression at baseline, which was disproportionately higher in females. Both factors must be taken into account in the analysis of findings.
This NIS is currently in the last year of follow-up observation.
We wish to thank all participating centres for their contribution to the BETAPATH study and Dr. med. J. Czekalla, Bayer HealthCare, Berlin, for his valuable contributions in designing the study.
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