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Table 13 (9) "Closeness of Fit" Calculations.

From: The genetic basis of multiple sclerosis: a model for MS susceptibility

  Number of Susceptibility Genes Required (n)
  5 10 11 12 13 14 15
Frequency of Susceptibility (r) Closeness of Fit (Target ≤4.0)
r = 0.25 24,106 29,422 28,838 28,228 29,694 29,258 28,805
r = 0.33 19,148 4,872 5,600 4,166 4,788 5,416 4,150
r = 0.5 2,139 459 555 451 320 378 189
r = 1 789 90 43.9 39.7 18.9 17.7 9.4
r = 2 394 21.4 12.1 6.9 3.3 2.4 2.5
r = 4 337 9.9 4.4 2.2 1.7 2.1 3.0
r = 8 286 6.8 3.1 1.9 2.3 3.4 4.4
r = 16 262 5.8 2.8 2.4 3.3 4.6 5.8
  Number of Susceptibility Genes Required (n)
  16 17 18 30 40 50 60
Frequency of Susceptibility (r) Closeness of Fit (Target ≤ 4.0)
r = 0.25 31,198 30,935 31,545 31,749 32,041 32,713 32,776
r = 0.33 3,137 3,593 4,106 1,459 1,280 885 2,042
r = 0.5 228 114 140 21.4 18.3 18.7 38.0
r = 1 5.9 6.2 4.7 8.5 10.6 11.8 11.6
r = 2 3.0 3.6 4.2 10.9 13.5 14.9 12.7
r = 4 4.0 5.1 6.3 13.2 15.5 16.8 14.9
r = 8 5.5 6.8 8.0 14.7 16.7 17.7 16.2
r = 16 6.8 8.1 9.4 15.6 17.3 18.2 18.3
  1. * (Targets are in bold; optimal fit is underlined)
  2. * Calculated as the sum of the squared percent deviations from published epidemiological observations (E) of the high (H) and low (L) estimates derived from the model for non-twin siblings, parents/children, offspring of conjugal MS couples, and second and third degree relatives of MS probands. For each category, this squared percent deviation is defined as: [(H - E)/E + (L - E)/E]2