Table 13 (9) "Closeness of Fit" Calculations.
From: The genetic basis of multiple sclerosis: a model for MS susceptibility
Number of Susceptibility Genes Required (n) | |||||||
|---|---|---|---|---|---|---|---|
5 | 10 | 11 | 12 | 13 | 14 | 15 | |
Frequency of Susceptibility (r) | Closeness of Fit (Target ≤4.0) | ||||||
r = 0.25 | 24,106 | 29,422 | 28,838 | 28,228 | 29,694 | 29,258 | 28,805 |
r = 0.33 | 19,148 | 4,872 | 5,600 | 4,166 | 4,788 | 5,416 | 4,150 |
r = 0.5 | 2,139 | 459 | 555 | 451 | 320 | 378 | 189 |
r = 1 | 789 | 90 | 43.9 | 39.7 | 18.9 | 17.7 | 9.4 |
r = 2 | 394 | 21.4 | 12.1 | 6.9 | 3.3 | 2.4 | 2.5 |
r = 4 | 337 | 9.9 | 4.4 | 2.2 | 1.7 | 2.1 | 3.0 |
r = 8 | 286 | 6.8 | 3.1 | 1.9 | 2.3 | 3.4 | 4.4 |
r = 16 | 262 | 5.8 | 2.8 | 2.4 | 3.3 | 4.6 | 5.8 |
Number of Susceptibility Genes Required (n) | |||||||
16 | 17 | 18 | 30 | 40 | 50 | 60 | |
Frequency of Susceptibility (r) | Closeness of Fit (Target ≤ 4.0) | ||||||
r = 0.25 | 31,198 | 30,935 | 31,545 | 31,749 | 32,041 | 32,713 | 32,776 |
r = 0.33 | 3,137 | 3,593 | 4,106 | 1,459 | 1,280 | 885 | 2,042 |
r = 0.5 | 228 | 114 | 140 | 21.4 | 18.3 | 18.7 | 38.0 |
r = 1 | 5.9 | 6.2 | 4.7 | 8.5 | 10.6 | 11.8 | 11.6 |
r = 2 | 3.0 | 3.6 | 4.2 | 10.9 | 13.5 | 14.9 | 12.7 |
r = 4 | 4.0 | 5.1 | 6.3 | 13.2 | 15.5 | 16.8 | 14.9 |
r = 8 | 5.5 | 6.8 | 8.0 | 14.7 | 16.7 | 17.7 | 16.2 |
r = 16 | 6.8 | 8.1 | 9.4 | 15.6 | 17.3 | 18.2 | 18.3 |