Articles

Autoimmune encephalitis with coexistent LGI1 and GABA_BR1 antibodies: case report

Autoimmune encephalitis (AE) with multiple auto-antibodies is of great clinical significance because its complex clinical manifestations and atypical imaging increase the difficulty of diagnosis, differential ...

Authors: Yi Xie, Jia Wen, Zhihua Zhao, Hongbo Liu and Nanchang Xie

Perfusion CT detects alterations in local cerebral flow of glioma related to IDH, MGMT and TERT status

The aim of this study was to investigate the relationship between tumor biology and values of cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), time to peak (TTP), permeability s...

Authors: Ke Wang, Yeming Li, Haiyang Cheng, Shenjie Li, Wei Xiang, Yang Ming, Ligang Chen and Jie Zhou

Evaluating dopamine transporter imaging as an enrichment biomarker in a phase 2 Parkinson’s disease trial

Dopamine transporter single-photon emission computed tomography (DaT-SPECT) can quantify the functional integrity of the dopaminergic nerve terminals and has been suggested as an imaging modality to verify the...

Authors: R. Matthew Hutchison, Karleyton C. Evans, Tara Fox, Minhua Yang, Jerome Barakos, Barry J. Bedell, Jesse M. Cedarbaum, Miroslaw Brys, Andrew Siderowf and Anthony E. Lang

Safety and efficacy of interleukin-6-receptor inhibitors in the treatment of neuromyelitis optica spectrum disorders: a meta-analysis

Interleukin-6-receptor inhibitors like Tocilizumab and Satralizumab are showing promising results in the treatment of Neuromyelitis Optica spectrum disorder (NMOSD). We aimed to investigate the efficacy and sa...

Authors: Sanjeev Kharel, Suraj Shrestha, Rajeev Ojha, Neha Guragain and Rakesh Ghimire

Diagnosis of orthostatic tremor using smartphone accelerometry

Primary orthostatic tremor (OT) is a rare movement disorder characterized by a 13–18 Hz leg tremor, which arises when standing and is relieved by walking/sitting. Those affected generally do not fall, but expe...

Authors: Nicholas E. Calvo and Joseph M. Ferrara

Prognostication of neurologic outcome using gray-white-matter-ratio in comatose patients after cardiac arrest

This study aimed to assess the prognostic value regarding neurologic outcome of CT neuroimaging based Gray-White-Matter-Ratio measurement in patients after resuscitation from cardiac arrest.

Authors: Konrad Kirsch, Stefan Heymel, Albrecht Günther, Kathleen Vahl, Thorsten Schmidt, Dominik Michalski, Michael Fritzenwanger, Paul Christian Schulze and Rüdiger Pfeifer

Correction to: Association between hyperpyrexia and poststroke outcomes in patients with recanalization after mechanical thrombectomy: a retrospective cohort study

An amendment to this paper has been published and can be accessed via the original article.

Authors: Man Chen, Jinghuan Fang, Xintong Wu, Qin Liu, Ling Feng and Li He

Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study

Anaemia has been reported to be associated with cognitive decline and Alzheimer’s disease (AD), but the associations between anaemia and cerebrospinal fluid (CSF) AD biomarkers are still unknown. This study ai...

Authors: Xin-Yu Yang, Xiao-He Hou, Yan-Lin Bi, Hao Hu, Xi-Peng Cao, Lan Tan, Jiu-Long Yang and Jin-Tai Yu

Association between multiple sclerosis and dietary patterns based on the traditional concept of food nature: a case-control study in Iran

It remains a matter of debate whether traditional concepts regarding the nature of food affect the development and progression of multiple sclerosis (MS).To date, there are limited studies that have investigat...

Authors: Mohammad Hossein Sharifi, Parisa Keshani, Alireza Salehi, Amir Mohammad Jaladat, Zahra Mirzaei and Alireza Nikseresht

Miller Fisher syndrome following BNT162b2 mRNA coronavirus 2019 vaccination

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began in late 2019. One of the vaccines approved against COVID-19 is the BNT162b2 mRNA ...

Authors: Yamato Nishiguchi, Hirofumi Matsuyama, Kuniko Maeda, Akihiro Shindo and Hidekazu Tomimoto

Development and external validation of a nomogram for neurosyphilis diagnosis among non-HIV patients: a cross-sectional study

The diagnosis of neurosyphilis is challenging due to the requirement of a lumbar puncture and cerebrospinal fluid (CSF) laboratory tests. Therefore, a convenient diagnostic nomogram for neurosyphilis is warran...

Authors: Wenjing Ge, Yang Zhang, Chao Peng, Dongdong Li, Lijie Gao, Jiajia Bao, Changling Li, Ning Chen, Dong Zhou and Li He

Assessment of non-progressive dysarthria: practice and attitude of speech and language therapists in Lebanon

Non-progressive dysarthria is an acquired motor speech disorder resulting from neurological diseases such as stroke and traumatic brain injury. The evidence base for the assessment of non-progressive dysarthri...

Authors: Marwa Summaka, Hayat Harati, Salem Hannoun, Hiba Zein, Nour Koubaisy, Youssef Fares and Zeina Nasser

Low cerebrospinal fluid Amyloid-βeta 1–42 in patients with tuberculous meningitis

Tuberculous meningitis (TBM) is an important disease leading to morbidity, disability and mortality that primarily affects children and immune-depressed patients. Specific neuromarkers predicting outcomes, sev...

Authors: Giacomo Stroffolini, Giulia Guastamacchia, Sabrina Audagnotto, Cristiana Atzori, Mattia Trunfio, Marco Nigra, Alessandro Di Stefano, Giovanni Di Perri and Andrea Calcagno

Tacrolimus-induced neurotoxicity from bipolar disorder to status epilepticus under the therapeutic serum level: a case report

Tacrolimus is a macrolide immunosuppressant widely used to prevent rejection after solid organ transplantation. In general, adverse events of tacrolimus occur more often as the concentration of tacrolimus in t...

Authors: Bora Jin, Ga Yeon Kim and Sang-Myung Cheon

Comprehensive analysis of expression, prognosis and immune infiltration for TIMPs in glioblastoma

Tissue inhibitors of metalloproteinase (TIMP) family proteins are peptidases involved in extracellular matrix (ECM) degradation. Various diseases are related to TIMPs, and the primary reason is that TIMPs can ...

Authors: Jinkun Han, Yajun Jing, Fubing Han and Peng Sun

Prognostic value of tumour volume in patients with a poor Karnofsky performance status scale – a bicentric retrospective study

Median overall survival (OS) after diagnosis of glioblastoma (GBM) remains 15 months amongst patients receiving aggressive surgical resection, chemotherapy and irradiation. Treatment of patients with a poor pr...

Authors: Melanie Barz, Julia Gerhardt, Stefanie Bette, A. Kaywan Aftahy, Thomas Huber, Stephanie E. Combs, Yu-Mi Ryang, Benedikt Wiestler, Marco Skardelly, Irina Gepfner-Tuma, Felix Behling, Friederike Schmidt-Graf, Bernhard Meyer and Jens Gempt

Acute posterior reversible encephalopathy syndrome (PRES) in setting of interferon-beta use: case presentation with reduction of edema in 72 h after cessation of interferon-beta therapy with sub-clinical inflammation

Posterior reversible encephalopathy syndrome (PRES) represents a transient change in mental status with associated vasogenic edema of cortical and subcortical brain structures. It is often attributed to multif...

Authors: Nicholas Dietz, Zarmina Mufti, Muhammed Yousaf, Randal Brown, Christopher Counts, Martin F. Bjurström, Brian J. Williams and David Robertson

Correction to: Rasch analysis of the Brain Injury Screening Tool (BIST) in mild traumatic brain injury

Authors: Nusratnaaz Shaikh, Alice Theadom, Richard Siegert, Natalie Hardaker, Doug King and Patria Hume

Determinants of migraine headache among regular undergraduate students, of Wollo University, Dessie, Ethiopia: cross–sectional study

The prevalence of migraine headaches varied from 2.4 to 48.5% worldwide among university students. As per the knowledge of the investigators, the study of migraine headaches is not done in this study area. Hen...

Authors: Mengesha Birkie, Mohammed Endris and Sintayehu Asnakew

Mapping connectivity fingerprints for presurgical evaluation of temporal lobe epilepsy

Surgery may render temporal lobe epilepsy (TLE) patients seizure-free. However, TLE is a heterogenous entity and surgical prognosis varies between patients. Network-based biomarkers have been shown to be alter...

Authors: Jacint Sala-Padro, Júlia Miró, Antoni Rodriguez-Fornells, Xavier Rifa-Ros, Gerard Plans, Mila Santurino, Mercè Falip and Estela Càmara

Fasciculation differences between ALS and non-ALS patients: an ultrasound study

Fasciculation is an important sign for the diagnosis of amyotrophic lateral sclerosis (ALS). Our study aimed to analyze the difference in fasciculation detected with muscle ultrasonography (MUS) between ALS pa...

Authors: Jingwen Liu, Yi Li, Jingwen Niu, Lei Zhang, Jing Fan, Yuzhou Guan, Liying Cui and Mingsheng Liu

Early argatroban and antiplatelet combination therapy in acute non-lacunar single subcortical infarct associated with mild intracranial atherosclerosis

Patients with acute non-lacunar single subcortical infarct (SSI) associated with mild intracranial atherosclerosis (ICAS) have a relatively high incidence of early neurological deterioration (END), resulting i...

Authors: Peng-Fei Wang, Zhuo-Ran Sun, Jin-Chao Yu, Na Geng, Ling-Yun Liu, Li-Na Zhu, Jing Li, Hai-Cheng Yuan, Guo-chen Zhao and Zhen-Guang Li

A p.Arg499His mutation in SPAST is associated with infantile-onset complicated spastic paraplegia: a case report and review of the literature

Spastic paraplegia type 4 (SPG4) is caused by mutations in the SPAST gene, is the most common form of autosomal-dominant pure hereditary spastic paraplegias (HSP), and is rarely associated with a complicated form...

Authors: Haitian Nan, Hiroshi Shiraku, Tomoko Mizuno and Yoshihisa Takiyama

FXYD2 mRNA expression represents a new independent factor that affects survival of glioma patients and predicts chemosensitivity of patients to temozolomide

Glioma is the most common primary intracranial tumor. Owing to the poor prognosis associated with high-grade gliomas, there is an urgent need to identify biomarkers related to prognosis and treatment sensitivi...

Authors: Kaijia Zhou, Tao Jiang, Yanwei Liu, Zheng Zhao, Lijie Huang and Guanzhang Li

20-hydroxyeiscosatetraenoic acid may be as a predictor of malignant middle cerebral artery infarction in patients with massive middle cerebral artery infarction

Early identification of massive middle cerebral artery infarction (MCAI) at risk for malignant MCAI (m-MCAI) may be useful in selecting patients for aggressive therapies. The aim of this study was to determine...

Authors: Xingyang Yi, Qiang Zhou, Ting Qing, Bing Ming, Jing Lin, Jie Li and Jie Lin

Association between small dense low-density lipoprotein cholesterol and neuroimaging markers of cerebral small vessel disease in middle-aged and elderly Chinese populations

Cerebral small vascular disease (CSVD) is one of the leading causes of death in the aged population and is closely related to abnormalities in low-density lipoprotein cholesterol (LDL-C). Our study aims to cla...

Authors: Xiaorong Yu, Yanhua Yu, Cunsheng Wei, Lin Wang, Junying Jiang, Rui Zhang, Qi Dai, Yue Kang and Xuemei Chen

Opinions and clinical practice of functional movement disorders: a nationwide survey of clinicians in China

There is rare reports about opinions and clinical practice of functional movement disorders (FMD) in China. The present survey aimed to investigate the views of FMD in Chinese clinicians.

Authors: Xin-Yi Xie, Guo-zhen Lin, Qiang Huang, Chun-Bo Li, Mark Hallett, Valerie Voon, Ru-jing Ren, Sheng-di Chen and Gang Wang

Outcomes of stroke patients undergoing thrombolysis in Sri Lanka; an observational prospective study from a low-middle income country

Stroke related deaths are relatively higher in low- and middle-income countries where only a fraction of eligible patients undergo thrombolysis. There is also limited evidence on post-thrombolysis outcomes of ...

Authors: H. M. M. T. B. Herath, Chaturaka Rodrigo, A. M. B. D. Alahakoon, Sathyajith Buddhika Ambawatte, Sunethra Senanayake, Bimsara Senanayake and Arjuna Fernando

Burden and correlates of cognitive impairment among hypertensive patients in Tanzania: a cross-sectional study

The evolution of cognitive impairment of vascular origin is increasingly becoming a prominent health threat particularly in this era where hypertension is the leading contributor of global disease burden and o...

Authors: Pedro Pallangyo, Zabella S. Mkojera, Makrina Komba, Lucy R. Mgopa, Smita Bhalia, Henry Mayala, Salma Wibonela, Nsajigwa Misidai, Happiness J. Swai, Jalack Millinga, Ester Chavala, Peter R. Kisenge and Mohamed Janabi

Ring finger sensory latency difference in the diagnosis and treatment of carpal tunnel syndrome

To explore the sensitivity of median and ulnar nerve sensory latency differences in diagnosing carpal tunnel syndrome (CTS) at different severities.

Authors: Qingping Wang, Hong Chu, Hongyang Wang, Yan Jin, Xiaoquan Zhao, Chao Weng and Zuneng Lu

Translation and validation of the Persian version of Godin Leisure-Time Exercise Questionnaire in patients with multiple sclerosis

Psychometric study.

Authors: Mohammad-Reza Fattahi, Pardis Noormohammadpour, Meysam Ramezani, Mohammad Ali Sahraian, Mohammad Ali Mansournia, Mastaneh Rajabian Tabesh, Mohamed Ali Mesgarof and Maryam Abolhasani

Contrast-induced encephalopathy mimicking stroke after a second cerebral DSA: an unusual case report

Contrast-induced encephalopathy (CIE) is a rare complication of the angiography process. CIE may mimic stroke symptoms clinically and subarachnoid hemorrhage radiologically. Previous CIE cases occurred after t...

Authors: Jiaying Li, Guanshu Qi, Huani Zhang, Gang Chen, Shuting Wang, Minli Yan and Zhichao Sun

Seeking healthcare services post-stroke: a qualitative descriptive study exploring family caregiver and stroke survivor perspectives in an asian setting

Exploration of the healthcare journey post-stroke is incomplete without acknowledging the crucial role of family caregivers. With limited literature documenting the role of caregivers in the healthcare journey...

Authors: Shilpa Tyagi, Nan Luo, Chuen Seng Tan, Kelvin Bryan Tan, Boon Yeow Tan, Edward Menon, N. Venketasubramanian, Wei Chin Loh, Shu Hui Fan, Kenneth Lam Thuan Yang, Audrey Swee Ling Chan, Aysha Farwin, Zunairah Binti Lukman and Gerald Choon-Huat Koh

Clinical features, treatment and prognosis of MuSK antibody-associated myasthenia gravis in Northwest China: a single-centre retrospective cohort study

To summarize the clinical characteristics of patients with muscle-specific kinase antibody-associated myasthenia gravis (MuSK-MG) and to evaluate the therapeutic responses to different treatment regimes.

Authors: Sijia Zhao, Kai Zhang, Kaixi Ren, Jiarui Lu, Chao Ma, Cong Zhao, Zhuyi Li and Jun Guo

Risk factors for nonresponsive hydration in patients with spinal cerebrospinal fluid leakage

Spinal cerebrospinal fluid (CSF) leakage is frequently encountered clinically after lumbar puncture or spontaneous events. Although some patients recover without treatment or after intensive hydration, some re...

Authors: Hung-Chieh Chen, Po-Lin Chen, Jyh-Wen Chai and Chieh-Lin Jerry Teng

Persistent intrathecal interleukin-8 production in a patient with SARS-CoV-2-related encephalopathy presenting aphasia: a case report.

Neurological manifestations of coronavirus disease 2019 (COVID-19) are increasingly recognized and include encephalopathy, although direct infection of the brain by SARS-CoV-2 remains controversial. We herein ...

Authors: Takuya Kudo, Yuichi Hayashi, Kenjiro Kunieda, Nobuaki Yoshikura, Akio Kimura, Mika Otsuki and Takayoshi Shimohata

The burden of medication overuse headache and patterns of switching and discontinuation among triptan users: a systematic literature review

A synthesis of real-world discontinuation and switching patterns among triptan users and rates of acute medication use among patients with medication overuse headache (MOH) is needed to better understand the b...

Authors: Alison M. Deighton, Linda A. Harris, Karissa Johnston, Shomari Hogan, Lynn A. Quaranta, Gilbert L’Italien and Vlad Coric

Effect of long-term adjuvant temozolomide chemotherapy on primary glioblastoma patient survival

Glioblastoma multiforme (GBM) is the most common primary malignant central nervous system (CNS) tumor. The Stupp regimen is the standard treatment, although the optimal number of temozolomide (TMZ) treatment c...

Authors: Bin Huang, Zuan Yu and Risheng Liang

The protective impact of education on brain structure and function in Alzheimer’s disease

The Cognitive Reserve (CR) theory posits that brains with higher reserve can cope with more cerebral damage to minimize clinical manifestations. The aim of this study was to examine the effect of education (CR...

Authors: Wanqiu Zhu, Xiaoshu Li, Xiaohu Li, Haibao Wang, Meiqin Li, Ziwen Gao, Xingqi Wu, Yanghua Tian, Shanshan Zhou, Kai Wang and Yongqiang Yu

Cholinesterase inhibitor to prevent falls in Parkinson’s disease (CHIEF-PD) trial: a phase 3 randomised, double-blind placebo-controlled trial of rivastigmine to prevent falls in Parkinson’s disease

Falls are a common complication of Parkinson’s disease. There is a need for new therapeutic options to target this debilitating aspect of the disease. Cholinergic deficit has been shown to contribute to both g...

Authors: S. Neumann, J. Taylor, A. Bamford, C. Metcalfe, D. M. Gaunt, A. Whone, D. Steeds, S. R. Emmett, W. Hollingworth, Y. Ben-Shlomo and E. J. Henderson

The length of susceptibility vessel sign predicts early neurological deterioration in minor acute ischemic stroke with large vessel occlusion

Patients with acute large vessel occlusion (LVO) presenting with minor stroke are at risk of early neurological deterioration (END). The present study aimed to evaluate the frequency and potential predictors o...

Authors: Lanying He, Jian Wang, Feng Wang, Lili Zhang, Lijuan Zhang, Wang Zhao, Xiechuan Weng and Fan Xu

Hemichorea in a patient with ipsilateral cortical infarction: a case report

Hemichorea is usually caused by contralateral deep structures of brain. It rarely results from acute cortical ischemic stroke and that caused by ipsilateral brain lesions is even rarer.

Authors: Jie Wei and Yue Zhang

Early amantadine treatment reduces the risk of death in patients with large hemisphere infarctions:a Chinese hospital-based study

Amantadine hydrochloride is one of the most frequently prescribed drugs for patients with severe traumatic brain injury in restoring consciousness and accelerating the pace of functional recovery. However, the...

Authors: Jie Li, Ping Zhang, Yingying Liu, Simiao Wu, Xingyang Yi, Shihong Zhang, Chun Wang and Ming Liu

The Canadian prospective cohort study to understand progression in multiple sclerosis (CanProCo): rationale, aims, and study design

Neurological disability progression occurs across the spectrum of people living with multiple sclerosis (MS). Although there are a handful of disease-modifying treatments approved for use in progressive phenot...

Authors: Jiwon Oh, Nathalie Arbour, Fabrizio Giuliani, Melanie Guenette, Shannon Kolind, Larry Lynd, Ruth Ann Marrie, Luanne M. Metz, Scott B. Patten, Alexandre Prat, Alice Schabas, Penelope Smyth, Roger Tam, Anthony Traboulsee and V. Wee Yong

Risk factors for postoperative cerebrospinal fluid leakage after transsphenoidal surgery for pituitary adenoma: a meta-analysis and systematic review

Postoperative cerebrospinal fluid (CSF) leakage represents a challenge even for experienced pituitary surgeons. We aimed to quantitatively synthesize data from studies regarding the risk factors for postoperat...

Authors: Zhihuan Zhou, Feifei Zuo, Xiaoqun Chen, Qinqin Zhao, Mengna Luo, Xiaobing Jiang and Yuyu Duan

Effects of phantom exercises on pain, mobility, and quality of life among lower limb amputees; a randomized controlled trial

The objective of the current study is to evaluate the effects of phantom exercises on phantom limb pain, mobility status, and quality of life in lower limb amputees treated with mirror therapy and routine phys...

Authors: Anna Zaheer, Arshad Nawaz Malik, Tahir Masood and Sahar Fatima

Development and validation of the disease - specific problems questionnaire for patients with multiple sclerosis

Patients with multiple sclerosis face numerous problems during their lifetime. A self-report measurement of disease - specific problems is required to be developed for patients with multiple sclerosis based on...

Authors: Ali Dehghani

MOG antibody-associated encephalitis secondary to Covid-19: case report

While Covid-19 predominantly affects the respiratory system, neurological manifestations including encephalitis occur in some patients, possibly affecting the course and outcome of the disease. Here, we descri...

Authors: Ervin Durovic, Corinna Bien, Christian G. Bien and Stefan Isenmann

Correction to: FXTAS is difficult to differentiate from neuronal intranuclear inclusion disease through skin biopsy: a case report

An amendment to this paper has been published and can be accessed via the original article.

Authors: Megumi Toko, Tomohiko Ohshita, Takashi Kurashige, Hiroyuki Morino, Kodai Kume, Hiroshi Yamashita, Gen Sobue, Yasushi Iwasaki, Jun Sone, Hideshi Kawakami and Hirofumi Maruyama

Longitudinal analysis of regional brain changes in anti-NMDAR encephalitis: a case report

Anti-NMDA receptor encephalitis is an immune-mediated disorder characterized by antibodies against the GluN1 subunit of the NMDA receptor that is increasingly recognized as a treatable cause of childhood epile...

Authors: Ryan M. Nillo, Iris J. Broce, Besim Uzgil, Nilika S. Singhal, Christine M. Glastonbury, Christopher P. Hess, James A. Barkovich, Rahul S. Desikan and Leo P. Sugrue