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  1. Transient ischemic attack (TIA) patients are at high risk of recurrent vascular events; timely management can reduce that risk by 70%. The Protocol-guided Rapid Evaluation of Veterans Experiencing New Transien...

    Authors: D. M. Bravata, L. J. Myers, B. Homoya, E. J. Miech, N. A. Rattray, A. J. Perkins, Y. Zhang, J. Ferguson, J. Myers, A. J. Cheatham, L. Murphy, B. Giacherio, M. Kumar, E. Cheng, D. A. Levine, J. J. Sico…

    Citation: BMC Neurology 2019 19:294

    Content type: Study protocol

    Published on:

  2. Neurological disorders are an economic and public health burden which requires efficient and adequate medical resources. Currently, little is known about the status of the quality of neurological care services...

    Authors: Jun-Fang Zhang, Meng-Yao Qiu, Yu-Lei Zhang, Xi-Xi Wang, Guo-Ping Wang, Yu Geng, Ke-Zhong Zhang, Kan Fang and Yun-Cheng Wu

    Citation: BMC Neurology 2019 19:293

    Content type: Research article

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  3. Antiepileptic drug (AED) induced dyskinesia is an unusual manifestation in the medical field. In the previous case reports describing first generation-AED related involuntary movements, the authors suggested t...

    Authors: Soo Hwan Yim, Yun Ho Choi, Kyoung Heo and Kyoo ho Cho

    Citation: BMC Neurology 2019 19:292

    Content type: Case report

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  4. Mutations of cyclooxygenase gene (COX gene) may increase the susceptibility of ischemic stroke. We investigated five variants (rs5788, rs1330344, rs3842788, rs20417, and rs689466) of two COX genes in order to ...

    Authors: Lei Zhao, Jinghuan Fang, Muke Zhou, Jie Zhou, Lihua Yu, Ning Chen and Li He

    Citation: BMC Neurology 2019 19:291

    Content type: Research article

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  5. In this paper, seizure types, and epilepsy syndromes are elucidated as per ILAE (2010) classification. A brief outline of the antiepileptic drug regimens used and the outcome of seizure control in a two -year ...

    Authors: Inaam N. Mohamed, Maha A. Elseed, Somia Mohamed, Ali Alsir, Emtinan K. Hamid, Ilham M. Omer, Sara M. Elsadig, Yasmin M. Gerais, Abdelgadir H. Osman, Aisha M. Bakhiet and Ahlam A. Hamed

    Citation: BMC Neurology 2019 19:290

    Content type: Research article

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  6. Ischemia-reperfusion (I/R)-induced vascular dysfunction is the main factor to acute ischemic stroke. Sirt3 is one of the sirtuin family members, which plays an important role in the development of neurological...

    Authors: Zhenzhen Zhao, Xiaoxiu Zhang, Yuanqiang Dai, Ke Pan, Yu Deng, Yan Meng and Tao Xu

    Citation: BMC Neurology 2019 19:289

    Content type: Research article

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  7. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis of unknown cause involving the brain and accompanied by prominent eosinophilia. Intracardiac thrombosis is a major cardiac com...

    Authors: Kenichiro Hira, Hideki Shimura, Riyu Kamata, Masashi Takanashi, Akane Hashizume, Keiji Takahashi, Mizuho Sugiyama, Hiroshi Izumi, Nobutaka Hattori and Takao Urabe

    Citation: BMC Neurology 2019 19:288

    Content type: Case report

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  8. Fingolimod (Gilenya®) is approved for relapsing forms of multiple sclerosis in the USA. Owing to transient heart-rate effects when initiating fingolimod, eligible patients undergo precautionary baseline assess...

    Authors: Brandon Brown, Jamie L. Weiss, Scott Kolodny, Xiangyi Meng, Ian M. Williams and John A. Osborne

    Citation: BMC Neurology 2019 19:287

    Content type: Research article

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  9. Some studies have looked at the age at menarche and risk of Multiple Sclerosis (MS).We aimed to conduct a systematic review and meta-analysis to estimate a pooled odds ratio of developing MS by increasing age ...

    Authors: Amirreza Azimi, Sara Hanaei, Mohammad Ali Sahraian, Mehdi Mohammadifar, Sreeram V. Ramagopalan and Mahsa Ghajarzadeh

    Citation: BMC Neurology 2019 19:286

    Content type: Research article

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  10. Capsular warning syndrome (CWS) is a rare clinical syndrome, which is defined as a recurrent transient lacunar syndrome. The mechanism and clinical management of CWS remain unclear. The aim of the study was to...

    Authors: Lanying He, Ronghua Xu, Jian Wang, Lili Zhang, Lijuan Zhang, Fangfang Zhou and Weiwei Dong

    Citation: BMC Neurology 2019 19:285

    Content type: Research article

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  12. As health behavior varies with increasing age, we aimed to examine the potential barriers in calling emergency medical services (EMS) after recognizing a stroke among 40–74- and 75–99-year-old adults.

    Authors: Shengde Li, Li-Ying Cui, Craig Anderson, Chunpeng Gao, Chengdong Yu, Guangliang Shan, Longde Wang and Bin Peng

    Citation: BMC Neurology 2019 19:283

    Content type: Research article

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  13. Diagnosing dysphagia in acute stroke patients is crucial, as this comorbidity determines morbidity and mortality; we therefore investigated the impact of flexible nasolaryngeal endoscopy (FEES) in acute stroke...

    Authors: Tobias Braun, Martin Juenemann, Maxime Viard, Marco Meyer, Iris Reuter, Mario Prosiegel, Manfred Kaps and Christian Tanislav

    Citation: BMC Neurology 2019 19:282

    Content type: Research article

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  15. Parkinson’s disease (PD) affects many physiological systems essential for balance control. Recent studies suggest that intensive and cognitively demanding physical exercise programs are capable of inducing pla...

    Authors: Erika Franzén, Hanna Johansson, Malin Freidle, Urban Ekman, Martin Benka Wallén, Ellika Schalling, Alexander Lebedev, Martin Lövdén, Staffan Holmin, Per Svenningsson and Maria Hagströmer

    Citation: BMC Neurology 2019 19:280

    Content type: Study protocol

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  16. Cerebral infarction occurs when the arteries to brain are obstructed, and motor impairment contralateral to responsible lesion is commonly recognized. Few studies have profiled the characteristics of cases wit...

    Authors: Zhe-Ren Tan, Chen Zhang and Fa-Fa Tian

    Citation: BMC Neurology 2019 19:279

    Content type: Research article

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  17. Wilson disease (WD) is genetically induced failure of copper metabolism which can be successfully treated with pharmacological agents. The prognosis for survival in most WD patients is favorable if diagnosis a...

    Authors: Wojciech Masełbas, Anna Członkowska, Tomasz Litwin and Maciej Niewada

    Citation: BMC Neurology 2019 19:278

    Content type: Research article

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  18. Early supported discharge (ESD) has been shown to be efficient and safe as part of the stroke care pathway. The best results have been seen with a multidisciplinary team and after mild to moderate stroke. Howe...

    Authors: Lena Rafsten, Anna Danielsson, Asa Nordin, Ann Björkdahl, Asa Lundgren-Nilsson, Maria E. H. Larsson and Katharina S. Sunnerhagen

    Citation: BMC Neurology 2019 19:277

    Content type: Research article

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  19. Internal carotid artery dissection has been well recognized as a major cause of ischaemic stroke in young and middle-aged adults. However, internal carotid artery dissection induced hypoglossal nerve palsy has...

    Authors: Zhaoyao Chen, Jun Yuan, Hui Li, Cuiping Yuan, Kailin Yin, Sen Liang, Pengfei Li and Minghua Wu

    Citation: BMC Neurology 2019 19:276

    Content type: Case report

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  20. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disease, whose exact cause remains unclear. A wide range of risk factors has been proposed that helps understanding potential disease pa...

    Authors: Eliana M. Lacerda, Keith Geraghty, Caroline C. Kingdon, Luigi Palla and Luis Nacul

    Citation: BMC Neurology 2019 19:275

    Content type: Research article

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  21. Early prediction of unfavorable outcome after ischemic stroke is of great significance to the clinical and therapeutic management. A nomogram is a better visual tool than earlier models and prognostic scores t...

    Authors: Chao Sun, Xiang Li, Baili Song, Xiangliang Chen, Linda Nyame, Yukai Liu, Dan Tang, Mako Ibrahim, Zheng Zhao, Chao Liu, Miao Yan, Xiding Pan, Jie Yang, Junshan Zhou and Jianjun Zou

    Citation: BMC Neurology 2019 19:274

    Content type: Research article

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  22. The incidence of autoimmune encephalitis has risen globally. There are two general categories of disease-associated antibodies that can be tested for: neuronal surface and intracellular. However, testing both ...

    Authors: Abhinbhen W. Saraya, Kanthita Worachotsueptrakun, Kritchai Vutipongsatorn, Chanikarn Sonpee and Thiravat Hemachudha

    Citation: BMC Neurology 2019 19:273

    Content type: Research article

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  23. Patients with acute ischemic stroke (AIS) often experience low serum free triiodothyronine (FT3), but the association of low FT3 with stroke severity, subtype and prognosis has not yet been thoroughly studied,...

    Authors: Shanchao Zhang, Xia Zhao, Shan Xu, Jing Yuan, Zhihua Si, Yang Yang, Shan Qiao, Xuxu Xu and Aihua Wang

    Citation: BMC Neurology 2019 19:272

    Content type: Research article

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  25. In the nineteenth century, Jean Martin Charcot explained functional neurological disorder (formerly called conversion disorder) as a “psychodynamic” lesion. Numerous advances in neuroimaging have permitted ide...

    Authors: Silvio Galli, Selma Aybek, Sylvie Chokron, Thierry Moulin and Eloi Magnin

    Citation: BMC Neurology 2019 19:270

    Content type: Case report

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  26. To determine whether items of the Chinese version of the Montreal Cognitive Assessment Basic (MoCA-BC) could discriminate among cognitively normal controls (NC), and those with mild cognitive impairment (MCI),...

    Authors: Yan-Rong Zhang, Yun-Long Ding, Ke-liang Chen, Yan Liu, Can Wei, Ting-ting Zhai, Wen-Juan Wang and Wan-Li Dong

    Citation: BMC Neurology 2019 19:269

    Content type: Research article

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  27. Secondary central nervous system lymphoma (SCNSL) is defined as secondary central nervous system (CNS) involvement in patients with systemic lymphoma. It is considered a profoundly adverse complication with in...

    Authors: Yuchen Wu, Yaming Wang, Xuefei Sun, Xueyan Bai, Jun Qian, Hong Zhu, Qu Cui, Ruixian Xing, Yuedan Chen, Qing Liu, Jiayuan Guo, Nan Ji, Shengjun Sun and Yuanbo Liu

    Citation: BMC Neurology 2019 19:268

    Content type: Research article

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  28. To study the association of caregiver factors and stroke patient factors with rehospitalizations over the first 3 months and subsequent 3–12 months post-stroke in Singapore.

    Authors: Shilpa Tyagi, Gerald C. H. Koh, Nan Luo, Kelvin B. Tan, Helen Hoenig, David B. Matchar, Joanne Yoong, Angelique Chan, Kim En Lee, N. Venketasubramanian, Edward Menon, Kin Ming Chan, Deidre Anne De Silva, Philip Yap, Boon Yeow Tan, Effie Chew…

    Citation: BMC Neurology 2019 19:267

    Content type: Research article

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  29. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disorder in the central nervous system (CNS) with distinct clinical, radiological, an...

    Authors: Xiao-hang Liu, Fan Jin, Meng Zhang, Mei-xi Liu, Tao Wang, Bo-ju Pan and Lu Zhang

    Citation: BMC Neurology 2019 19:266

    Content type: Case report

    Published on:

  30. Intravenous thrombolysis (IVT) plays a prominent role in the treatment of acute ischemic stroke (AIS). The sooner IVT is administered, the higher the odds of a good outcome. Therefore, registering the in-hospi...

    Authors: Laurien S. Kuhrij, Perla J. Marang-van de Mheen, Renske M. van den Berg-Vos, Frank-Erik de Leeuw and Paul J. Nederkoorn

    Citation: BMC Neurology 2019 19:265

    Content type: Research article

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  31. As investigations of disease modifying drugs aim to slow down progression of Alzheimer’ disease (AD) biomarkers to reliably track disease progression gain more importance. This is especially important as clini...

    Authors: Marion Ortner, René Drost, Dennis Heddderich, Oliver Goldhardt, Felix Müller-Sarnowski, Janine Diehl-Schmid, Hans Förstl, Igor Yakushev and Timo Grimmer

    Citation: BMC Neurology 2019 19:264

    Content type: Research article

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  32. Progressive multifocal leukoencephalopathy (PML) is a rapidly developing demyelinating disease in the cerebral white matter and is often caused by JC polyomavirus (JCV). PML after lung transplantation is rare ...

    Authors: Kazuhiro Ishii, Fumiko Yamamoto, Shinsuke Homma, Yoshinori Okada, Kazuo Nakamichi, Masayuki Saijo and Akira Tamaoka

    Citation: BMC Neurology 2019 19:263

    Content type: Case report

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  33. Failing to recognise the signs and symptoms of subarachnoid haemorrhage (SAH) causes diagnostic delay and may result in poorer outcomes. We report a rare case of SAH secondary to a vertebral artery dissection ...

    Authors: Lloyd Steele, Muhammad Hasan Raza, Richard Perry, Neil Rane and Sophie J. Camp

    Citation: BMC Neurology 2019 19:262

    Content type: Case report

    Published on:

  34. Little is known about the clinical phenotype of amyotrophic lateral sclerosis (ALS) in non-Caucasian populations. Here, we aimed to describe the clinical characteristics, prognostic factors and survival of Mex...

    Authors: Claudia Marisol Sánchez-Martínez, José Alberto Choreño-Parra, Lilia Nuñez-Orozco, Noel Placencia-Álvarez, Laura Marcela Alvis-Castaño and Parménides Guadarrama-Ortiz

    Citation: BMC Neurology 2019 19:261

    Content type: Research article

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  35. Parkinsonism is a complex multifactorial neurodegenerative disorder, in which genetic and environmental risk factors may both play a role. Among environmental risk factors cocaine was earlier ambiguously linke...

    Authors: Anett Illés, Péter Balicza, Viktor Molnár, Renáta Bencsik, István Szilvási and Maria Judit Molnar

    Citation: BMC Neurology 2019 19:260

    Content type: Case report

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  36. The aim of this study was to evaluate the correlation between significant asymptomatic carotid artery stenosis (ACAS) and severity of peripheral arterial occlusive disease (PAOD) in the lower limb, and to inve...

    Authors: Zhongjie Pan, Ruitao Wang, Li Li and Hua Zhang

    Citation: BMC Neurology 2019 19:259

    Content type: Research article

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  37. Multiple sclerosis (MS) is prevalent among working age individuals (20–60 years), leading to high burden on work productivity. Few data are available about the absenteeism and presenteeism in employed individu...

    Authors: Jacqueline A. Nicholas, Batul Electricwala, Lulu K. Lee and Kristen M. Johnson

    Citation: BMC Neurology 2019 19:258

    Content type: Research article

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  39. Spastic paraplegia, optic atrophy and neuropathy (Spoan syndrome) is an autosomal recessive disease with approximately 70 cases recorded in Brazil and Egypt.

    Authors: Cláudia R. C. Galvão, Priscilla M. A. Cavalcante, Ricardo Olinda, Zodja Graciani, Mayana Zatz, Fernando Kok, Silvana Santos and Selma Lancman

    Citation: BMC Neurology 2019 19:256

    Content type: Research article

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  40. Many patients with chronic illness have sexual dysfunction that may be related to the condition itself, drug side effects, emotional sequel, or a combination of those factors. Patients with epilepsy are no exc...

    Authors: Alem K. Ejigu, Kelemwa H. Zewlde, Niguse Y. Muluneh, Zehara R. Seraj, Mahlet W. GebreLibanos and Yodit H. Bezabih

    Citation: BMC Neurology 2019 19:255

    Content type: Research article

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  41. Demyelinating central nervous system diseases include several disorders that multiple sclerosis (MS) is identified as the most common among them. Ocular movement disturbances are a typical presentation in MS p...

    Authors: Amirhossein Akhavan Sigari, Masoud Etemadifar and Mehri Salari

    Citation: BMC Neurology 2019 19:254

    Content type: Case report

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  42. We encountered two unrelated individuals suffering from neurological disorders, including epilepsy and scoliosis.

    Authors: Kouhei Den, Yosuke Kudo, Mitsuhiro Kato, Kosuke Watanabe, Hiroshi Doi, Fumiaki Tanaka, Hirokazu Oguni, Satoko Miyatake, Takeshi Mizuguchi, Atsushi Takata, Noriko Miyake, Satomi Mitsuhashi and Naomichi Matsumoto

    Citation: BMC Neurology 2019 19:253

    Content type: Case report

    Published on:

  43. Progressive multifocal leukoencephalopathy (PML) is a demyelinating disorder caused by JC virus (JCV). Although detecting JCV DNA in the cerebrospinal fluid (CSF) by real-time polymerase chain reaction (PCR) i...

    Authors: Kazuo Nakamichi, Michi Kawamoto, Junko Ishii and Masayuki Saijo

    Citation: BMC Neurology 2019 19:252

    Content type: Research article

    Published on:

  44. Elevated blood pressure (BP) at emergency department (ED) presentation and advancing age have been associated with risk of ischemic stroke; however, the relationship between BP, age, and transient ischemic att...

    Authors: Andrew M. Penn, Nicole S. Croteau, Kristine Votova, Colin Sedgwick, Robert F. Balshaw, Shelagh B. Coutts, Melanie Penn, Kaitlin Blackwood, Maximilian B. Bibok, Viera Saly, Janka Hegedus, Amy Y. X. Yu, Charlotte Zerna, Evgenia Klourfeld and Mary L. Lesperance

    Citation: BMC Neurology 2019 19:251

    Content type: Research article

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  45. Progressive neurological diseases, such as multiple sclerosis, Parkinson’s disease, Huntington’s disease, significantly interfere with patients’ lives, and those of their families. The aim of the research was ...

    Authors: Radka Bužgová and Radka Kozáková

    Citation: BMC Neurology 2019 19:250

    Content type: Research article

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  46. Cardiac myxoma is the most common benign cardiac tumor. Brain metastases or multiple cerebral aneurysms are extremely rare, especially for the case of both complications. Brain metastases are usually found at ...

    Authors: Yan Wan, Hai Du, Lei Zhang, Shuang Guo, Li Xu, Yuanyuan Li, Hui He, Lian Zhou, Yunping Chen, Ling Mao, Huijuan Jin and Bo Hu

    Citation: BMC Neurology 2019 19:249

    Content type: Case report

    Published on:

  47. Migraine is a primary headache disorder, which cause significant disability in adolescence. This double blind, randomized clinical trial assessed the immediate effects of suction of paranasal sinus air during ...

    Authors: S. M. R. Bandara, S. Samita, A. M. Kiridana, D. M. P. U. K. Ralapanawa and H. M. M. T. B. Herath

    Citation: BMC Neurology 2019 19:248

    Content type: Research article

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  48. Palbociclib is a selective well-tolerated antineoplastic drug used in the treatment of advanced HER2-negative, estrogen-receptor positive breast cancer that has shown significant improvement in progression-fre...

    Authors: Vardan Nersesjan, Klaus Hansen, Thomas Krag, Morten Duno and Tina D. Jeppesen

    Citation: BMC Neurology 2019 19:247

    Content type: Case report

    Published on:

  49. To describe a patient with sleep alleviated episodic ataxia type 2 with a novel CACNA1A pathogenic variant and provide a possible link to sleep responsive migraine.

    Authors: Abhimanyu S. Ahuja, Todd D. Rozen and Paldeep S. Atwal

    Citation: BMC Neurology 2019 19:246

    Content type: Case report

    Published on:

  50. The purpose of this study was to report our preliminary experience of stent-assisted coiling (SAC) of wide-necked intracranial aneurysms with a single microcatheter in patients with parent arteries that were s...

    Authors: Keun Young Park, Chang Ki Jang, Jae Whan Lee, Dong Joon Kim, Byung Moon Kim and Joonho Chung

    Citation: BMC Neurology 2019 19:245

    Content type: Technical advance

    Published on:

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