Articles

Effects of low-frequency repetitive transcranial magnetic stimulation combined with cerebellar continuous theta burst stimulation on spasticity and limb dyskinesia in patients with stroke

Repetitive transcranial magnetic stimulation (rTMS) has been reported to treat muscle spasticity in post-stroke patients. The purpose of this study was to explore whether combined low-frequency rTMS (LF-rTMS) ...

Authors: Dawei Li, Aixia Cheng, Zhiyou Zhang, Yuqian Sun and Yingchun Liu

Combination of structural MRI, functional MRI and brain PET-CT provide more diagnostic and prognostic value in patients of cerebellar ataxia associated with anti-Tr/DNER: a case report

Brain magnetic resonance imaging (MRI) rarely reveals structural changes in patients with suspected anti-Tr/DNER encephalitis and thus provides very limited information. Here, we combined structural MRI, funct...

Authors: Sisi Shen, Wenyu Liu, Ming Zhou, Ruiyi Yang, Jinmei Li and Dong Zhou

Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

Many antiseizure medications (ASMs) control seizures by blocking voltage-dependent sodium channels. Polymorphisms of sodium channel genes may affect the response to ASMs due to altering the effect of ASMs on b...

Authors: Chih-Hsiang Lin, Chen-Jui Ho, Yan-Ting Lu and Meng-Han Tsai

Clinical heterogeneity of low flow spinal arteriovenous fistulas; a case series

Spinal AVF (SAVF), a potentially treatable cause of myelopathy, remains a challenging diagnosis. Its rarity and non-specific imaging findings often result in misdiagnosis despite a high index of clinical suspi...

Authors: D. Krishnan, S. Viswanathan, N. Rose, H. S. N. Benjamin, A. M. Ong and F. L. Hiew

Association between hyperpyrexia and poststroke outcomes in patients with recanalization after mechanical thrombectomy: a retrospective cohort study

Limited data are available for evaluating the relationship between the prognosis and body temperature (BT) in patients treated with mechanical thrombectomy (MT), especially in those with successful recanalizat...

Authors: Man Chen, Jinghuan Fang, Xintong Wu, Qin Liu, Ling Feng and Li He

Influence of white matter lesions on the prognosis of acute cardioembolic stroke without reperfusion therapy

Few studies have investigated the influence of white matter lesions (WMLs) on the prognosis of acute cardioembolic stroke (CES). We aimed to explore the role of WMLs in predicting 3-month prognosis of CES with...

Authors: Yikun Guo, Zhuoyou Chen, Qian Wang, Min Zhang, Guanzhong Dong, Wenying Zou, Tian Yao and Yun Xu

The role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy

When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20–65%). Hybrid FDG-PET/MRI may provide addi...

Authors: Márton Tóth, Péter Barsi, Zoltán Tóth, Katalin Borbély, János Lückl, Miklós Emri, Imre Repa, József Janszky, Tamás Dóczi, Zsolt Horváth, Péter Halász, Vera Juhos, Csilla Gyimesi, Beáta Bóné, Diána Kuperczkó, Réka Horváth…

Acute ischemic stroke with cervical internal carotid artery steno-occlusive lesion: multicenter analysis of endovascular approaches

Occlusion of the internal carotid artery (ICA), whether isolated or in the setting of a tandem lesion (TL) have a poor response to treatment with intravenous thrombolysis. Previous studies ​​have demonstrated ...

Authors: Luigi Cirillo, Daniele Giuseppe Romano, Gianfranco Vornetti, Giulia Frauenfelder, Chiara Tamburrano, Francesco Taglialatela, Salvatore Isceri, Renato Saponiero, Rosa Napoletano, Mauro Gentile, Michele Romoli, Ciro Princiotta, Luigi Simonetti and Andrea Zini

Decreased nocturnal heart rate variability and potentially related brain regions in arteriosclerotic cerebral small vessel disease

To assess heart rate variability (HRV) among patients with arteriosclerotic cerebral small vessel disease (CSVD) by comparing with control subjects, and to determine whether HRV parameters were related to stru...

Authors: Miaoyi Zhang, Huan Yu, Weijun Tang, Ding Ding, Jie Tang, Na Liu, Yang Xue, Xue Ren, Langfeng Shi and Jianhui Fu

Association between low-density cholesterol change and outcomes in acute ischemic stroke patients who underwent reperfusion therapy

Low-density lipoprotein cholesterol (LDL-C) can increase cardiovascular risk. However, the association between LDL-C change and functional outcomes in acute ischemic stroke (AIS) patients who underwent reperfu...

Authors: Ting Cui, Changyi Wang, Qiange Zhu, Anmo Wang, Xuening Zhang, Shucheng Li, Yuan Yang, Wenzuo Shang, Rong Peng and Bo Wu

Clinical significance of stroke nurse in patients with acute ischemic stroke receiving intravenous thrombolysis

Reports have proven that shorter door-to-needle time (DTN time) indicates better outcomes in AIS patients received intravenous thrombolysis. Efforts have been made by hospitals and centers to minimize DTN time...

Authors: Zhao-Han Xu, Qi-Wen Deng, Qian Zhai, Qing Zhang, Zhen-Jie Wang, Wen-Xia Chen, Meng-Meng Gu, Teng Jiang, Jun-Shan Zhou and Ying-Dong Zhang

A novel de novo KDM5C variant in a female with global developmental delay and ataxia: a case report

Pathogenic variants in KDM5C are a cause of X-linked intellectual disability in males. Other features in males include short stature, dysmorphic features, seizures and spasticity. In some instances, female relati...

Authors: Natalie C. Lippa, Subit Barua, Vimla Aggarwal, Elaine Pereira and Jennifer M. Bain

Translation, adaptation and validation of the Bulgarian version of the King’s Parkinson’s Disease Pain Scale

The purpose of the present study was to translate and cross-culturally adapt the King’s Parkinson’s Disease Pain Scale (KPPS) into Bulgarian and to investigate its psychometric properties in order to provide a...

Authors: Galina Stoyanova-Piroth, Ivan Milanov and Katerina Stambolieva

Reversible splenial lesion syndrome with mental disorders as only manifestation

Reversible splenial lesion syndrome (RESLES) was reported to be associated with variable entities. However, much less is known about the cases in which the mental disorders act as the only manifestation.

Authors: Ziyun Xu, Zhaoguang Zhou, Wentao Jang, Jianhong Tian and Gangqiang Hou

Diazepam induced sleep spindle increase correlates with cognitive recovery in a child with epileptic encephalopathy

Continuous spike and wave of sleep with encephalopathy (CSWS) is a rare and severe developmental electroclinical epileptic encephalopathy characterized by seizures, abundant sleep activated interictal epilepti...

Authors: S. M. Stoyell, B. S. Baxter, J. McLaren, H. Kwon, D. M. Chinappen, L. Ostrowski, L. Zhu, J. A. Grieco, M. A. Kramer, A. K. Morgan, B. C. Emerton, D. S. Manoach and C. J. Chu

Correction to: Understanding the relationship between the 32-item motor function measure and daily activities from an individual with spinal muscular atrophy and their caregivers’ perspective: a two-part study

Authors: Tina Duong, Jessica Braid, Hannah Staunton, Aurelie Barriere, Fani Petridis, Johannes Reithinger, Rosangel Cruz, Jill Jarecki, Mencia De Lemus, Nicole Gusset, Ria Broekgaarden, Sharan Randhawa, Jessica Flynn, Rob Arbuckle, Sonia Reif, Lida Yang…

Reduced default mode network connectivity relative to white matter integrity is associated with poor cognitive outcomes in patients with idiopathic normal pressure hydrocephalus

The aim of this study was to investigate whether default mode network (DMN) connectivity and brain white matter integrity at baseline were associated with severe cognitive impairments at baseline and poor cogn...

Authors: Shigenori Kanno, Kun-ichi Ogawa, Hiroaki Kikuchi, Masako Toyoshima, Nobuhito Abe, Kazushi Sato, Koichi Miyazawa, Ryuji Oshima, Satoru Ohtomo, Hiroaki Arai, Satoshi Shibuya and Kyoko Suzuki

Rosai-Dorfman disease in the central nervous system with two isolated lesions originated from a single clone: a case report

Rosai–Dorfman disease (RDD) is a rare, benign, idiopathic non-Langerhans cell histiocytosis. Cases of RDD in the CNS are extremely rare but lethal. RDD is thought to represent a reactive process. Recent studie...

Authors: Huawei Jin, Zhenhua Yu, Tian Tian, Guoping Shen, Weian Chen, Miao Fan, Qun He, Fei Xu and Dawei Liu

Correlation of active contact location with weight gain after subthalamic nucleus deep brain stimulation: a case series

Weight gain (WG) is a frequently reported side effect of subthalamic deep brain stimulation; however, the underlying mechanisms remain unclear. The active contact locations influence the clinical outcomes of s...

Authors: Katsuki Eguchi, Shinichi Shirai, Masaaki Matsushima, Takahiro Kano, Kazuyoshi Yamazaki, Shuji Hamauchi, Toru Sasamori, Toshitaka Seki, Kenji Hirata, Mayumi Kitagawa, Mika Otsuki, Tohru Shiga, Kiyohiro Houkin, Hidenao Sasaki and Ichiro Yabe

Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients

Asymptomatic carotid artery stenosis (aCAS) impairs haemodynamic and cognitive functions; however, the relationship between these changes and brain network connectivity remains largely unknown. This study aime...

Authors: Shihao He, Ran Duan, Ziqi Liu, Cai Zhang, Tian Li, Yanchang Wei, Ning Ma and Rong Wang

Prevalence and associated factors of premature discontinuation of antiplatelet therapy after ischemic stroke: a nationwide population-based study

We tried to evaluate the prevalence of premature discontinuation of antiplatelets and its affecting factors after ischemic stroke using large-sized representative national claims data.

Authors: Seung Jae Kim, Oh Deog Kwon, Ho Chun Choi, Eung-Joon Lee, BeLong Cho and Dae Hyun Yoon

Overlapping syndrome mimicking infectious meningoencephalitis in a patient with MOG and GFAP IgG

Central nervous system overlapping autoimmune syndromes are uncommon, especially with the coexistence of MOG-IgG and GFAP-IgG.

Authors: Suqiong Ji, Chenchen Liu, Zhuajin Bi, Huajie Gao, Jian Sun and Bitao Bu

I can’t count, but I can beat you playing cards: a case report on autoimmune encephalitis

Autoimmune encephalitis (AE) is a rare inflammatory disorder characterized by important psychiatric and neurologic symptoms. The literature documents high rates of neuropsychological dysfunction in N-methyl D-...

Authors: Laura Mori, William Campanella, Lucilla Vestito, Lucio Marinelli, Luana Benedetti, Leonardo Cocito and Carlo Trompetto

Might life-threatening acute pulmonary edema occur after using recombinant tissue plasminogen activator? A case report

Recombinant tissue plasminogen activator (rt-pa) is the first-line drug for the treatment of acute ischemic stroke, and can lead to some complications.There were rare reports of death due to acute pulmonary ed...

Authors: Xue-Bing Chen, Dong Qu, Qing Zhang, Xia Yue and Dong-Fang Qiao

Impact of COVID-19 pandemic on migraine management in the United States: insights from migraine tracking app users

The nature of COVID-19 pandemic measures has altered the clinical management of migraine, and has also created barriers to evaluate the impact of such measures of migraine patients. Using the Migraine Buddy sm...

Authors: Yuji Kato, Weijie Poh, Zsolt Horvath, François Cadiou, Tomokazu Shimazu and Yuichi Maruki

Determinants of nutritional status and outcome in adults with RCSE: a retrospective cohort study

This study aimed to investigate the association between nutritional characteristics in patients with refractory convulsive status epilepticus.

Authors: Zhang Yu and Liu Ling

Long-term telemetric intracranial pressure monitoring for diagnosis and therapy optimisation of idiopathic intracranial hypertension

Idiopathic intracranial hypertension (IIH) is a disease which is difficult to diagnose and moreover difficult to treat. We developed a strategy for long-term telemonitoring of intracranial pressure (ICP), by i...

Authors: Victor F. Velazquez Sanchez, Giath Al Dayri and Christoph A. Tschan

Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study

Recent resting-state fMRI studies demonstrated functional dysconnectivity within the central pain matrix in migraineurs. This study aimed to investigate the spatial distribution and amplitude of low-frequency ...

Authors: Ye Eun Kim, Min Kyung Kim, Sang-il Suh and Ji Hyun Kim

Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke

We aimed to explore the association of serum level of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) and its related inflammatory biomarkers (hypoxia induc...

Authors: Yanan Wang, Hexiao Huang, Weihong He, Shihong Zhang, Ming Liu and Simiao Wu

Association between the HLA-B*1502 gene and mild maculopapular exanthema induced by antiepileptic drugs in Northwest China

The relationship between the HLA-B*1502 gene and maculopapular exanthema (MPE) induced by antiepileptic drugs (AEDs) has not yet been elucidated. In this study, we investigated the association between AED-indu...

Authors: Nilupaer Shafeng, Deng-feng Han, Yun-fang Ma, Rena Abudusalamu and Binuer Ayitimuhan

Controlled arterial hypotension during resection of cerebral arteriovenous malformations

Resection of cerebral arteriovenous malformations (AVM) is technically demanding because of size, eloquent location or diffuse nidus. Controlled arterial hypotension (CAH) could facilitate haemostasis. We perf...

Authors: Katharina Riedel, Marcus Thudium, Azize Boström, Johannes Schramm and Martin Soehle

Long QT syndrome with potassium voltage-gated channel subfamily H member 2 gene mutation mimicking refractory epilepsy: case report

Epileptic seizures can be difficult to distinguish from other etiologies that cause cerebral hypoxia, especially cardiac diseases. Long QT syndrome (LQTS), especially LQTS type 2 (LQT2), frequently masquerades...

Authors: Huicong Kang, Lili Lan, Yuchao Jia, Cun Li, Yongkang Fang, Suiqiang Zhu and Heidi Kirsch

Wearable inertial sensors are highly sensitive in the detection of gait disturbances and fatigue at early stages of multiple sclerosis

The aim of the current study was to examine multiple gait parameters obtained by wearable inertial sensors and their sensitivity to clinical status in early multiple sclerosis (MS). Further, a potential correl...

Authors: Roy Müller, Daniel Hamacher, Sascha Hansen, Patrick Oschmann and Philipp M. Keune

Primary ectopic parasellar craniopharyngioma: a case report

Craniopharyngioma (CP) is a slow-growing, benign tumor of the central nervous system located within the sellar and suprasellar regions. The tumor may extend from the suprasellar region to other areas. CPs are ...

Authors: Xintao Cai, Zhixiang Sun, Yu Li, Dongqi Shao, Xialin Zheng, Yu Wang and Zhiquan Jiang

Impairment of the visuospatial working memory in the patients with Parkinson’s Disease: an fMRI study

Mild cognitive impairment (MCI) is a common symptom in the patients with Parkinson’s disease (PD). The characteristics of cognitive impairment in PD are executive function (including working memory) and visuo-...

Authors: Shoji Kawashima, Yoko Shimizu, Yoshino Ueki and Noriyuki Matsukawa

Neuronal intranuclear inclusion disease presented with recurrent vestibular migraine-like attack: a case presentation

Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder characterized by dementia, tremor, episodic encephalopathy and autonomic nervous dysfunction. To date, vestibular migraine (VM)-li...

Authors: Danhua Zhao, Sha Zhu, Qinlan Xu, Jianwen Deng, Zhaoxia Wang and Xianzeng Liu

Assessing multiple sclerosis-related quality of life among Iranian patients using the MSQOL-54 tool: a cross-sectional study

Multiple sclerosis (MS) is a chronic autoimmune disease and is one of the most costly medical conditions that imposed families with catastrophic health expenditures. There is an increasing trend in using alter...

Authors: Shadi Ziaie, Niloofar Namazi, Golnaz Afzal, Saghar Barati, Rezvaneh Mohebbi, Mahshad Mir, Hadi Esmaily and Gholamhossein Mehralian

Impact of social and mobility restrictions in Parkinson’s disease during COVID-19 lockdown

The consequences of strict COVID-19 mobility restrictions on motor/non-motor features in Parkinson’s disease (PD) have not been systematically studied but worse mobility and quality of life have been reported....

Authors: Raquel Luis-Martínez, Roberto Di Marco, Luca Weis, Valeria Cianci, Francesca Pistonesi, Alfonc Baba, Miryam Carecchio, Roberta Biundo, Chiara Tedesco, Stefano Masiero and Angelo Antonini

Validation of quantitative gait analysis systems for Parkinson’s disease for use in supervised and unsupervised environments

Gait impairments are among the most common and impactful symptoms of Parkinson’s disease (PD). Recent technological advances aim to quantify these impairments using low-cost wearable systems for use in either ...

Authors: Sara Alberto, Sílvia Cabral, João Proença, Filipa Pona-Ferreira, Mariana Leitão, Raquel Bouça-Machado, Linda Azevedo Kauppila, António P. Veloso, Rui M. Costa, Joaquim J. Ferreira and Ricardo Matias

Alterations of structural connectivity and structural co-variance network in focal cortical dysplasia

The aim of this study was to investigate alterations in structural connectivity and structural co-variance network in patients with focal cortical dysplasia (FCD).

Authors: Dong Ah Lee, Ho-Joon Lee, Hyung Chan Kim and Kang Min Park

A neuro-cardiac self-regulation therapy to improve autonomic and neural function after SCI: a randomized controlled trial protocol

Spinal cord injury (SCI) is associated with autonomic imbalance and significant secondary conditions, including cardiac and brain dysfunction that adversely impact health and wellbeing. This study will investi...

Authors: Ashley Craig, Ilaria Pozzato, Mohit Arora, James Middleton, Dianah Rodrigues, Candice McBain, Yvonne Tran, Glen M. Davis, Bamini Gopinath, Annette Kifley, Andrei Krassioukov, Jeffrey Braithwaite, Rebecca Mitchell, Sylvia M. Gustin, Jacob Schoffl and Ian D. Cameron

Positive DAT-SCAN in SPG7: a case report mimicking possible MSA-C

Spastic Paraplegia type 7 (SPG7) is one of the most common autosomal recessive Hereditary Spastic Paraplegias (HSP); Spastic Paraplegias (SPGs) can present as hereditary ataxias. However, ataxia is frequently ...

Authors: Gabriele Bellini, Eleonora Del Prete, Elisa Unti, Daniela Frosini, Gabriele Siciliano and Roberto Ceravolo

Different resting-state network disruptions in newly diagnosed drug-naïve Parkinson’s disease patients with mild cognitive impairment

Cognitive impairment is a common non-motor symptom in patients with Parkinson’s disease (PD). Mild cognitive impairment (MCI) is also prevalent in nondemented PD patients, even in newly diagnosed PD patients. ...

Authors: Yanbing Hou, Qianqian Wei, Ruwei Ou, Lingyu Zhang, Xiaoqin Yuan, Qiyong Gong and Huifang Shang

Longitudinal observational study of boxing therapy in Parkinson’s disease, including adverse impacts of the COVID-19 lockdown

Parkinson’s Disease (PD) is a highly prevalent neurodegenerative disease whose incidence is increasing with an aging population. One of the most serious manifestations of PD is gait instability, leading to fal...

Authors: Craig Horbinski, Katelyn B. Zumpf, Kathleen McCortney and Dean Eoannou

Prognostic analysis of different therapeutic regimens in patients with acute cardiogenic cerebral embolism

Few studies focused on the functional outcomes of patients at 3 months after receiving intravenous thrombolysis, anticoagulation, or antiplatelet therapy within 4.5 h of onset of the cardiogenic cerebral embol...

Authors: Lan Hu, Guangxin Duan, Yuan Xu and Yongjun Cao

Clinical characteristics of middle-aged and older patients with MS treated with interferon beta-1b: post-hoc analysis of a 2-year, prospective, international, observational study

Despite trends towards the increased age of patients living with multiple sclerosis (MS), little is known about the response of older adults with MS to disease-modifying therapies (DMTs). Thus, a post-hoc analysi...

Authors: Francesco Patti, Javier Nicolas Penaherrera, Lorissa Zieger and Eva-Maria Wicklein

Primary neuroendocrine tumor of the pineal gland: a case report

Primary intracranial neuroendocrine tumors are exceedingly rare, with few cases in the literature. We present a case of a primary neuroendocrine carcinoma of the pineal gland, which is the second that has ever...

Authors: Angela Cheng, Jane Barron, Oliver Holmes, Peter Bartlett, Gregory Jenkins and Melanie Seal

Stroke risk factors, subtypes and outcome in elderly Thai patients

Nowadays, the number of elderly has steadily increased annually.

Authors: Chatpol Samuthpongtorn, Tul Jereerat and Nijasri C. Suwanwela

Guillain-Barré syndrome as the first presentation of human immunodeficiency virus infection

Antiretroviral therapy (ART) development has reduced the severity of neurological complications of the human immunodeficiency virus (HIV), but they remain prevalent and need prompt recognition. Acute inflammat...

Authors: Mariana Lopes, Patrícia Marques, Bruno Silva, Gonçalo Cruz, José Eduardo Serra, Eugenia Ferreira, Helena Alves and José Saraiva da Cunha

Longitudinal changes in the inferior cerebellar peduncle and lower limb motor recovery following subcortical infarction

The cerebellum receives afferent signals from spinocerebellar pathways regulating lower limb movements. However, the longitudinal changes in the spinocerebellar pathway in the early stage of unilateral suprate...

Authors: Gang Liu, Yaomin Guo, Chao Dang, Kangqiang Peng, Shuangquan Tan, Chuanmiao Xie, Shihui Xing and Jinsheng Zeng