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  1. The aim of this study was to investigate the relationship between tumor biology and values of cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), time to peak (TTP), permeability s...

    Authors: Ke Wang, Yeming Li, Haiyang Cheng, Shenjie Li, Wei Xiang, Yang Ming, Ligang Chen and Jie Zhou

    Citation: BMC Neurology 2021 21:460

    Content type: Research

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  2. Dopamine transporter single-photon emission computed tomography (DaT-SPECT) can quantify the functional integrity of the dopaminergic nerve terminals and has been suggested as an imaging modality to verify the...

    Authors: R. Matthew Hutchison, Karleyton C. Evans, Tara Fox, Minhua Yang, Jerome Barakos, Barry J. Bedell, Jesse M. Cedarbaum, Miroslaw Brys, Andrew Siderowf and Anthony E. Lang

    Citation: BMC Neurology 2021 21:459

    Content type: Research article

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  3. Interleukin-6-receptor inhibitors like Tocilizumab and Satralizumab are showing promising results in the treatment of Neuromyelitis Optica spectrum disorder (NMOSD). We aimed to investigate the efficacy and sa...

    Authors: Sanjeev Kharel, Suraj Shrestha, Rajeev Ojha, Neha Guragain and Rakesh Ghimire

    Citation: BMC Neurology 2021 21:458

    Content type: Research

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  4. Primary orthostatic tremor (OT) is a rare movement disorder characterized by a 13–18 Hz leg tremor, which arises when standing and is relieved by walking/sitting. Those affected generally do not fall, but expe...

    Authors: Nicholas E. Calvo and Joseph M. Ferrara

    Citation: BMC Neurology 2021 21:457

    Content type: Research

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  5. This study aimed to assess the prognostic value regarding neurologic outcome of CT neuroimaging based Gray-White-Matter-Ratio measurement in patients after resuscitation from cardiac arrest.

    Authors: Konrad Kirsch, Stefan Heymel, Albrecht Günther, Kathleen Vahl, Thorsten Schmidt, Dominik Michalski, Michael Fritzenwanger, Paul Christian Schulze and Rüdiger Pfeifer

    Citation: BMC Neurology 2021 21:456

    Content type: Research article

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  6. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Man Chen, Jinghuan Fang, Xintong Wu, Qin Liu, Ling Feng and Li He

    Citation: BMC Neurology 2021 21:455

    Content type: Correction

    Published on:

    The original article was published in BMC Neurology 2021 21:365

  7. Anaemia has been reported to be associated with cognitive decline and Alzheimer’s disease (AD), but the associations between anaemia and cerebrospinal fluid (CSF) AD biomarkers are still unknown. This study ai...

    Authors: Xin-Yu Yang, Xiao-He Hou, Yan-Lin Bi, Hao Hu, Xi-Peng Cao, Lan Tan, Jiu-Long Yang and Jin-Tai Yu

    Citation: BMC Neurology 2021 21:454

    Content type: Research

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  8. It remains a matter of debate whether traditional concepts regarding the nature of food affect the development and progression of multiple sclerosis (MS).To date, there are limited studies that have investigat...

    Authors: Mohammad Hossein Sharifi, Parisa Keshani, Alireza Salehi, Amir Mohammad Jaladat, Zahra Mirzaei and Alireza Nikseresht

    Citation: BMC Neurology 2021 21:453

    Content type: Research

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  9. The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began in late 2019. One of the vaccines approved against COVID-19 is the BNT162b2 mRNA ...

    Authors: Yamato Nishiguchi, Hirofumi Matsuyama, Kuniko Maeda, Akihiro Shindo and Hidekazu Tomimoto

    Citation: BMC Neurology 2021 21:452

    Content type: Case report

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  10. The diagnosis of neurosyphilis is challenging due to the requirement of a lumbar puncture and cerebrospinal fluid (CSF) laboratory tests. Therefore, a convenient diagnostic nomogram for neurosyphilis is warran...

    Authors: Wenjing Ge, Yang Zhang, Chao Peng, Dongdong Li, Lijie Gao, Jiajia Bao, Changling Li, Ning Chen, Dong Zhou and Li He

    Citation: BMC Neurology 2021 21:451

    Content type: Research

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  11. Non-progressive dysarthria is an acquired motor speech disorder resulting from neurological diseases such as stroke and traumatic brain injury. The evidence base for the assessment of non-progressive dysarthri...

    Authors: Marwa Summaka, Hayat Harati, Salem Hannoun, Hiba Zein, Nour Koubaisy, Youssef Fares and Zeina Nasser

    Citation: BMC Neurology 2021 21:450

    Content type: Research

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  12. Tuberculous meningitis (TBM) is an important disease leading to morbidity, disability and mortality that primarily affects children and immune-depressed patients. Specific neuromarkers predicting outcomes, sev...

    Authors: Giacomo Stroffolini, Giulia Guastamacchia, Sabrina Audagnotto, Cristiana Atzori, Mattia Trunfio, Marco Nigra, Alessandro Di Stefano, Giovanni Di Perri and Andrea Calcagno

    Citation: BMC Neurology 2021 21:449

    Content type: Research

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  13. Tacrolimus is a macrolide immunosuppressant widely used to prevent rejection after solid organ transplantation. In general, adverse events of tacrolimus occur more often as the concentration of tacrolimus in t...

    Authors: Bora Jin, Ga Yeon Kim and Sang-Myung Cheon

    Citation: BMC Neurology 2021 21:448

    Content type: Case report

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  14. Median overall survival (OS) after diagnosis of glioblastoma (GBM) remains 15 months amongst patients receiving aggressive surgical resection, chemotherapy and irradiation. Treatment of patients with a poor pr...

    Authors: Melanie Barz, Julia Gerhardt, Stefanie Bette, A. Kaywan Aftahy, Thomas Huber, Stephanie E. Combs, Yu-Mi Ryang, Benedikt Wiestler, Marco Skardelly, Irina Gepfner-Tuma, Felix Behling, Friederike Schmidt-Graf, Bernhard Meyer and Jens Gempt

    Citation: BMC Neurology 2021 21:446

    Content type: Research article

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  15. Posterior reversible encephalopathy syndrome (PRES) represents a transient change in mental status with associated vasogenic edema of cortical and subcortical brain structures. It is often attributed to multif...

    Authors: Nicholas Dietz, Zarmina Mufti, Muhammed Yousaf, Randal Brown, Christopher Counts, Martin F. Bjurström, Brian J. Williams and David Robertson

    Citation: BMC Neurology 2021 21:445

    Content type: Case report

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  16. The prevalence of migraine headaches varied from 2.4 to 48.5% worldwide among university students. As per the knowledge of the investigators, the study of migraine headaches is not done in this study area. Hen...

    Authors: Mengesha Birkie, Mohammed Endris and Sintayehu Asnakew

    Citation: BMC Neurology 2021 21:443

    Content type: Research

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  17. Surgery may render temporal lobe epilepsy (TLE) patients seizure-free. However, TLE is a heterogenous entity and surgical prognosis varies between patients. Network-based biomarkers have been shown to be alter...

    Authors: Jacint Sala-Padro, Júlia Miró, Antoni Rodriguez-Fornells, Xavier Rifa-Ros, Gerard Plans, Mila Santurino, Mercè Falip and Estela Càmara

    Citation: BMC Neurology 2021 21:442

    Content type: Research

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  18. Fasciculation is an important sign for the diagnosis of amyotrophic lateral sclerosis (ALS). Our study aimed to analyze the difference in fasciculation detected with muscle ultrasonography (MUS) between ALS pa...

    Authors: Jingwen Liu, Yi Li, Jingwen Niu, Lei Zhang, Jing Fan, Yuzhou Guan, Liying Cui and Mingsheng Liu

    Citation: BMC Neurology 2021 21:441

    Content type: Research

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  19. Patients with acute non-lacunar single subcortical infarct (SSI) associated with mild intracranial atherosclerosis (ICAS) have a relatively high incidence of early neurological deterioration (END), resulting i...

    Authors: Peng-Fei Wang, Zhuo-Ran Sun, Jin-Chao Yu, Na Geng, Ling-Yun Liu, Li-Na Zhu, Jing Li, Hai-Cheng Yuan, Guo-chen Zhao and Zhen-Guang Li

    Citation: BMC Neurology 2021 21:440

    Content type: Research

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  20. Spastic paraplegia type 4 (SPG4) is caused by mutations in the SPAST gene, is the most common form of autosomal-dominant pure hereditary spastic paraplegias (HSP), and is rarely associated with a complicated form...

    Authors: Haitian Nan, Hiroshi Shiraku, Tomoko Mizuno and Yoshihisa Takiyama

    Citation: BMC Neurology 2021 21:439

    Content type: Case report

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  21. Glioma is the most common primary intracranial tumor. Owing to the poor prognosis associated with high-grade gliomas, there is an urgent need to identify biomarkers related to prognosis and treatment sensitivi...

    Authors: Kaijia Zhou, Tao Jiang, Yanwei Liu, Zheng Zhao, Lijie Huang and Guanzhang Li

    Citation: BMC Neurology 2021 21:438

    Content type: Research article

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  22. Early identification of massive middle cerebral artery infarction (MCAI) at risk for malignant MCAI (m-MCAI) may be useful in selecting patients for aggressive therapies. The aim of this study was to determine...

    Authors: Xingyang Yi, Qiang Zhou, Ting Qing, Bing Ming, Jing Lin, Jie Li and Jie Lin

    Citation: BMC Neurology 2021 21:437

    Content type: Research article

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  23. Cerebral small vascular disease (CSVD) is one of the leading causes of death in the aged population and is closely related to abnormalities in low-density lipoprotein cholesterol (LDL-C). Our study aims to cla...

    Authors: Xiaorong Yu, Yanhua Yu, Cunsheng Wei, Lin Wang, Junying Jiang, Rui Zhang, Qi Dai, Yue Kang and Xuemei Chen

    Citation: BMC Neurology 2021 21:436

    Content type: Research

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  24. There is rare reports about opinions and clinical practice of functional movement disorders (FMD) in China. The present survey aimed to investigate the views of FMD in Chinese clinicians.

    Authors: Xin-Yi Xie, Guo-zhen Lin, Qiang Huang, Chun-Bo Li, Mark Hallett, Valerie Voon, Ru-jing Ren, Sheng-di Chen and Gang Wang

    Citation: BMC Neurology 2021 21:435

    Content type: Research

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  25. Stroke related deaths are relatively higher in low- and middle-income countries where only a fraction of eligible patients undergo thrombolysis. There is also limited evidence on post-thrombolysis outcomes of ...

    Authors: H. M. M. T. B. Herath, Chaturaka Rodrigo, A. M. B. D. Alahakoon, Sathyajith Buddhika Ambawatte, Sunethra Senanayake, Bimsara Senanayake and Arjuna Fernando

    Citation: BMC Neurology 2021 21:434

    Content type: Research

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  26. The evolution of cognitive impairment of vascular origin is increasingly becoming a prominent health threat particularly in this era where hypertension is the leading contributor of global disease burden and o...

    Authors: Pedro Pallangyo, Zabella S. Mkojera, Makrina Komba, Lucy R. Mgopa, Smita Bhalia, Henry Mayala, Salma Wibonela, Nsajigwa Misidai, Happiness J. Swai, Jalack Millinga, Ester Chavala, Peter R. Kisenge and Mohamed Janabi

    Citation: BMC Neurology 2021 21:433

    Content type: Research

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  27. Contrast-induced encephalopathy (CIE) is a rare complication of the angiography process. CIE may mimic stroke symptoms clinically and subarachnoid hemorrhage radiologically. Previous CIE cases occurred after t...

    Authors: Jiaying Li, Guanshu Qi, Huani Zhang, Gang Chen, Shuting Wang, Minli Yan and Zhichao Sun

    Citation: BMC Neurology 2021 21:430

    Content type: Case report

    Published on:

  28. Exploration of the healthcare journey post-stroke is incomplete without acknowledging the crucial role of family caregivers. With limited literature documenting the role of caregivers in the healthcare journey...

    Authors: Shilpa Tyagi, Nan Luo, Chuen Seng Tan, Kelvin Bryan Tan, Boon Yeow Tan, Edward Menon, N. Venketasubramanian, Wei Chin Loh, Shu Hui Fan, Kenneth Lam Thuan Yang, Audrey Swee Ling Chan, Aysha Farwin, Zunairah Binti Lukman and Gerald Choon-Huat Koh

    Citation: BMC Neurology 2021 21:429

    Content type: Research

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  29. To summarize the clinical characteristics of patients with muscle-specific kinase antibody-associated myasthenia gravis (MuSK-MG) and to evaluate the therapeutic responses to different treatment regimes.

    Authors: Sijia Zhao, Kai Zhang, Kaixi Ren, Jiarui Lu, Chao Ma, Cong Zhao, Zhuyi Li and Jun Guo

    Citation: BMC Neurology 2021 21:428

    Content type: Research

    Published on:

  30. Neurological manifestations of coronavirus disease 2019 (COVID-19) are increasingly recognized and include encephalopathy, although direct infection of the brain by SARS-CoV-2 remains controversial. We herein ...

    Authors: Takuya Kudo, Yuichi Hayashi, Kenjiro Kunieda, Nobuaki Yoshikura, Akio Kimura, Mika Otsuki and Takayoshi Shimohata

    Citation: BMC Neurology 2021 21:426

    Content type: Case report

    Published on:

  31. A synthesis of real-world discontinuation and switching patterns among triptan users and rates of acute medication use among patients with medication overuse headache (MOH) is needed to better understand the b...

    Authors: Alison M. Deighton, Linda A. Harris, Karissa Johnston, Shomari Hogan, Lynn A. Quaranta, Gilbert L’Italien and Vlad Coric

    Citation: BMC Neurology 2021 21:425

    Content type: Research

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  32. The Cognitive Reserve (CR) theory posits that brains with higher reserve can cope with more cerebral damage to minimize clinical manifestations. The aim of this study was to examine the effect of education (CR...

    Authors: Wanqiu Zhu, Xiaoshu Li, Xiaohu Li, Haibao Wang, Meiqin Li, Ziwen Gao, Xingqi Wu, Yanghua Tian, Shanshan Zhou, Kai Wang and Yongqiang Yu

    Citation: BMC Neurology 2021 21:423

    Content type: Research article

    Published on:

  33. Falls are a common complication of Parkinson’s disease. There is a need for new therapeutic options to target this debilitating aspect of the disease. Cholinergic deficit has been shown to contribute to both g...

    Authors: S. Neumann, J. Taylor, A. Bamford, C. Metcalfe, D. M. Gaunt, A. Whone, D. Steeds, S. R. Emmett, W. Hollingworth, Y. Ben-Shlomo and E. J. Henderson

    Citation: BMC Neurology 2021 21:422

    Content type: Study protocol

    Published on:

  34. Patients with acute large vessel occlusion (LVO) presenting with minor stroke are at risk of early neurological deterioration (END). The present study aimed to evaluate the frequency and potential predictors o...

    Authors: Lanying He, Jian Wang, Feng Wang, Lili Zhang, Lijuan Zhang, Wang Zhao, Xiechuan Weng and Fan Xu

    Citation: BMC Neurology 2021 21:421

    Content type: Research

    Published on:

  35. Amantadine hydrochloride is one of the most frequently prescribed drugs for patients with severe traumatic brain injury in restoring consciousness and accelerating the pace of functional recovery. However, the...

    Authors: Jie Li, Ping Zhang, Yingying Liu, Simiao Wu, Xingyang Yi, Shihong Zhang, Chun Wang and Ming Liu

    Citation: BMC Neurology 2021 21:419

    Content type: Research article

    Published on:

  36. Neurological disability progression occurs across the spectrum of people living with multiple sclerosis (MS). Although there are a handful of disease-modifying treatments approved for use in progressive phenot...

    Authors: Jiwon Oh, Nathalie Arbour, Fabrizio Giuliani, Melanie Guenette, Shannon Kolind, Larry Lynd, Ruth Ann Marrie, Luanne M. Metz, Scott B. Patten, Alexandre Prat, Alice Schabas, Penelope Smyth, Roger Tam, Anthony Traboulsee and V. Wee Yong

    Citation: BMC Neurology 2021 21:418

    Content type: Study protocol

    Published on:

  37. Postoperative cerebrospinal fluid (CSF) leakage represents a challenge even for experienced pituitary surgeons. We aimed to quantitatively synthesize data from studies regarding the risk factors for postoperat...

    Authors: Zhihuan Zhou, Feifei Zuo, Xiaoqun Chen, Qinqin Zhao, Mengna Luo, Xiaobing Jiang and Yuyu Duan

    Citation: BMC Neurology 2021 21:417

    Content type: Research

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  38. The objective of the current study is to evaluate the effects of phantom exercises on phantom limb pain, mobility status, and quality of life in lower limb amputees treated with mirror therapy and routine phys...

    Authors: Anna Zaheer, Arshad Nawaz Malik, Tahir Masood and Sahar Fatima

    Citation: BMC Neurology 2021 21:416

    Content type: Research

    Published on:

  39. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Megumi Toko, Tomohiko Ohshita, Takashi Kurashige, Hiroyuki Morino, Kodai Kume, Hiroshi Yamashita, Gen Sobue, Yasushi Iwasaki, Jun Sone, Hideshi Kawakami and Hirofumi Maruyama

    Citation: BMC Neurology 2021 21:413

    Content type: Publisher Correction

    Published on:

    The original article was published in BMC Neurology 2021 21:396

  40. Anti-NMDA receptor encephalitis is an immune-mediated disorder characterized by antibodies against the GluN1 subunit of the NMDA receptor that is increasingly recognized as a treatable cause of childhood epile...

    Authors: Ryan M. Nillo, Iris J. Broce, Besim Uzgil, Nilika S. Singhal, Christine M. Glastonbury, Christopher P. Hess, James A. Barkovich, Rahul S. Desikan and Leo P. Sugrue

    Citation: BMC Neurology 2021 21:412

    Content type: Case report

    Published on:

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