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  1. Content type: Research article

    Adrenoleukodystrophy is a rare neurogenetic disease, AMN is the most common adult phenotype, such patients in China have not gotten enough attention. This article aims to study the features of AMN in Chinese p...

    Authors: Jie Li, Hongfen Wang, Zizi He, Xiangqing Wang, Jing Tang and Dehui Huang

    Citation: BMC Neurology 2019 19:227

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  2. Content type: Case report

    Due to improvements in both the quality and availability of intracranial imaging as well as the evolution of surgical and endovascular techniques during the last decade, the number of treatments of unruptured ...

    Authors: Christin Campe, Jens Neumann, I. Erol Sandalcioglu, Ali Rashidi and Michael Luchtmann

    Citation: BMC Neurology 2019 19:226

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  3. Content type: Correction

    Following publication of the original article [1], the authors reported an error in Table 2 wherein the item numbering in the first column is wrong.

    Authors: Erika Shirley Moreira da Silva, Gabriela Lopes Santos, Aparecida Maria Catai, Alexandra Borstad, Natália Pereira Duarte Furtado, Isabela Arruda Verzola Aniceto and Thiago Luiz Russo

    Citation: BMC Neurology 2019 19:225

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    The original article was published in BMC Neurology 2019 19:196

  4. Content type: Study protocol

    Facioscapulohumeral muscular dystrophy (FSHD) is a dominantly-inherited progressive muscular dystrophy caused by de-repression of the DUX4 gene, which causes disease by a toxic-gain-of-function. As molecularly ta...

    Authors: Samantha LoRusso, Nicholas E. Johnson, Michael P. McDermott, Katy Eichinger, Russell J. Butterfield, Elena Carraro, Kiley Higgs, Leann Lewis, Karlien Mul, Sabrina Sacconi, Valeria A. Sansone, Perry Shieh, Baziel van Engelen, Kathryn Wagner, Leo Wang, Jeffrey M. Statland…

    Citation: BMC Neurology 2019 19:224

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  5. Content type: Study protocol

    Hip fracture represents a substantial acute inflammatory trauma, which may constitute a significant insult to the degenerating brain. Research suggests that an injury of this kind can affect memory and thinkin...

    Authors: Nick Leavey, Simon P. Hammond, Lee Shepstone, Jane Cross, Henrik Zetterberg, Colm Cunningham, Alasdair MacLullich, Leiv Otto Watne, Anne Marie Minihane, Clive Ballard, Anne-Brita Knapskog, Roanna Hall, Gregory Howard, Matt Hammond and Chris Fox

    Citation: BMC Neurology 2019 19:223

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  6. Content type: Research article

    Treatment of spasticity poses a major challenge in amyotrophic lateral sclerosis (ALS) patient management. Delta-9-tetrahydrocannabinol (THC):cannabidiol (CBD) oromucosal spray (THC:CBD), approved for the trea...

    Authors: Thomas Meyer, Andreas Funke, Christoph Münch, Dagmar Kettemann, André Maier, Bertram Walter, Annett Thomas and Susanne Spittel

    Citation: BMC Neurology 2019 19:222

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  7. Content type: Research article

    Self-rated health (SRH) allows for comparison and identification of the health status of various populations. The aim of this study was to conduct a systematic review of the literature to expand the understand...

    Authors: Érika de Freitas Araújo, Ramon Távora Viana, Luci Fuscaldi Teixeira-Salmela, Lidiane Andrea Oliveira Lima and Christina Danielli Coelho de Morais Faria

    Citation: BMC Neurology 2019 19:221

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  8. Content type: Research article

    Stroke patients are often affected by long-term disabilities with needs concerning social issues. There is relatively little consideration of social recovery of patients and the support required to return to w...

    Authors: Sophie Lehnerer, Benjamin Hotter, Inken Padberg, Petra Knispel, Dike Remstedt, Andrea Liebenau, Ulrike Grittner, Ian Wellwood and Andreas Meisel

    Citation: BMC Neurology 2019 19:220

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  9. Content type: Research article

    Amongst the most challenging diagnostic dilemmas managing patients with vestibular symptoms (i.e. vertigo, nausea, imbalance) is differentiating dangerous central vestibular disorders from benign causes. Migra...

    Authors: Tzu-Pu Chang, Ariel A. Winnick, Yung-Chu Hsu, Pi-Yu Sung and Michael C. Schubert

    Citation: BMC Neurology 2019 19:219

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  10. Content type: Research article

    Microvascular decompression (MVD) is a type of neurosurgery used to treat trigeminal neuralgia (TN) caused by the vertebrobasilar contact/compression. The surgery is not risk-free, however; it may cause recurr...

    Authors: Xuhui Wang, Hong Wang, Sha Chen, Hong Liang, Hao Wang, Minhui Xu and Lunshan Xu

    Citation: BMC Neurology 2019 19:217

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  11. Content type: Study protocol

    Sciatica is a condition that is characterised by radicular pain in the leg and primarily caused by a herniated lumbar intervertebral disk. In addition to leg pain, patients can experience back pain, leg numbne...

    Authors: Eduard Verheijen, Alexander G. Munts, Oscar van Haagen, Dirk de Vries, Olaf Dekkers, Wilbert van den Hout and Carmen Vleggeert-Lankamp

    Citation: BMC Neurology 2019 19:216

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  12. Content type: Case report

    Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is one of the most frequent types of autoimmune encephalitis. However, the instigating mechanisms are as yet not fully ascertained. Cardinal clinical man...

    Authors: Huafang Jia, Xiaoli Xie, Faying Qi, Long Wang, Lijuan Wang and Fengyuan Che

    Citation: BMC Neurology 2019 19:215

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  13. Content type: Case report

    Posterior reversible encephalopathy syndrome (PRES) is a rare neurological disorder usually associated with specific medical conditions that cause a disturbance of the CNS homeostasis. It has seldom been repor...

    Authors: Brent G. Oxford, Nicolas K. Khattar, Shawn W. Adams, Alexandra S. Schaber and Brian J. Williams

    Citation: BMC Neurology 2019 19:214

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  14. Content type: Research article

    The global burden of stroke epidemiology is changing rapidly. Over the 1990–2013 periods, there was a significant increase in the absolute number of deaths and incident events of stroke. The burden of stroke v...

    Authors: Ginenus Fekadu, Legese Chelkeba and Ayantu Kebede

    Citation: BMC Neurology 2019 19:213

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  15. Content type: Case report

    THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine o...

    Authors: Hee Jin Kim, Hanna Cho, Seongbeom Park, Hyemin Jang, Young Hoon Ryu, Jae Yong Choi, Seung Hwan Moon, Seung Jun Oh, Minyoung Oh, Duk L. Na, Chul Hyoung Lyoo, Eun-Joo Kim, William W. Seeley, Jae Seung Kim, Kyung Chan Choi and Sang Won Seo

    Citation: BMC Neurology 2019 19:211

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  16. Content type: Case report

    Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, which is the most common type of autoimmune encephalitis, is caused by the production of autoantibodies against NMDA receptor. Anti-NMDAR encephali...

    Authors: Jie Lu, Ji-hong Zhang, Ai-liang Miao, Jun-xiong Yin, Dong-lin Zhu, Xing-jian Lin, Dao-wen Chen and Jing-ping Shi

    Citation: BMC Neurology 2019 19:210

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  17. Content type: Research article

    The Treatment Burden Questionnaire (TBQ) is a self-reported measure of the effect of treatment workload on patient wellbeing. We sought to validate the TBQ in Spanish and use it to estimate the burden of treat...

    Authors: María Célica Ysrraelit, Marcela Paula Fiol, Fernando Vazquez Peña, Sandra Vanotti, Sergio Adrián Terrasa, Viet-Thi Tran, Victor M. Montori and Jorge Correale

    Citation: BMC Neurology 2019 19:209

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  18. Content type: Research article

    Cytokines in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) patients compared with healthy controls have been extensively studied. However, the evidence ...

    Authors: Matthew Corbitt, Natalie Eaton-Fitch, Donald Staines, Hélène Cabanas and Sonya Marshall-Gradisnik

    Citation: BMC Neurology 2019 19:207

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  19. Content type: Research article

    Subcortical ischemic vascular dementia (SIVD) is very common among the older people, but has no approved treatment. Preclinical trials show that remote ischemic conditioning (RIC) reduces recurrence of ischemi...

    Authors: Zhangyuan Liao, Yali Bu, Meijie Li, Ranran Han, Nan Zhang, Junwei Hao and Wei Jiang

    Citation: BMC Neurology 2019 19:206

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  20. Content type: Research article

    Non motor symptoms (NMS) of Parkinson’s disease (PD) are common and can be more disabling than motor symptoms. Sleep disorders can be seen in up to 98% of patients with Parkinson disease. Poor sleep quality ha...

    Authors: Dereje Melka, Abenet Tafesse, James H. Bower and Demeke Assefa

    Citation: BMC Neurology 2019 19:205

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  21. Content type: Case report

    Vanishing white matter disease (VWMD) is one of the most prevalent inherited leukoencephalopathies, which generally presents in childhood as a progressive disorder while less beginning in adulthood. The presen...

    Authors: Cuibai Wei, Qi Qin, Fei Chen, Aihong Zhou, Fen Wang, Xiumei Zuo, Rong Chen, Jihui Lyu and Jianping Jia

    Citation: BMC Neurology 2019 19:203

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  22. Content type: Research article

    Rates of thrombolysis in most countries are well below best practice benchmarks. We aimed to investigate thrombolysis utilization and its associated factors in acute ischemic stroke (AIS) patients in Hubei pro...

    Authors: Yanfeng Zhou, Shijiao Yan, Xingyue Song, Yanhong Gong, Wenzhen Li, Mengdie Wang, Xiaoxv Yin, Bo Hu and Zuxun Lu

    Citation: BMC Neurology 2019 19:202

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  23. Content type: Case report

    Primary central nervous system (CNS) small lymphocytic lymphoma (SLL), as a type of low-grade lymphoma, is extremely rare. The diagnosis of CNS SLL is challenging due to its variable clinical and radiological ...

    Authors: Rongjing Guo, Xiaolong Zhang, Chunxiao Niu, Yibin Xi, Hong Yin, Hong Lin and Ting Chang

    Citation: BMC Neurology 2019 19:200

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  24. Content type: Correction

    Following publication of the original article [1], the authors reported errors in reference citations found in Table 1.

    Authors: Carolin Siegert, Björn Hauptmann, Nicole Jochems, Andreas Schrader and Ruth Deck

    Citation: BMC Neurology 2019 19:199

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    The original article was published in BMC Neurology 2019 19:143

  25. Content type: Case report

    Myofibrillar myopathies (MFMs) are a genetically heterogeneous group of muscle disorders. Mutations in the filamin C gene (FLNC) have previously been identified in patients with MFM. The phenotypes of FLNC-relate...

    Authors: Juanjuan Chen, Jun Wu, Chunxi Han, Yao Li, Yuzu Guo and Xiaoxin Tong

    Citation: BMC Neurology 2019 19:198

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  26. Content type: Research article

    Mechanical thrombectomy (MT) using stent retriever assisted vacuum-locked extraction (SAVE) is a promising method for anterior circulation strokes. We present our experience with SAVE for large vessel occlusio...

    Authors: Volker Maus, Hanna Styczen, Jan Liman, Ilko Maier, Alex Brehm, Ioannis Tsogkas and Marios-Nikos Psychogios

    Citation: BMC Neurology 2019 19:197

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  27. Content type: Study protocol

    Recovery of upper limb function in individuals after a stroke remains challenging. Modified constraint-induced movement therapy (m-CIMT) has strong evidence for increasing the use and recovery of sensorimotor ...

    Authors: Erika Shirley Moreira da Silva, Gabriela Lopes Santos, Aparecida Maria Catai, Alexandra Borstad, Natália Pereira Duarte Furtado, Isabela Arruda Verzola Aniceto and Thiago Luiz Russo

    Citation: BMC Neurology 2019 19:196

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    The Correction to this article has been published in BMC Neurology 2019 19:225

  28. Content type: Research article

    Previous studies have shown that obstructive sleep apnea (OSA) is associated with a higher risk of cognitive impairment or dementia in the elderly, leading to deleterious health effects and decreasing quality ...

    Authors: Talha Mubashir, Lusine Abrahamyan, Ayan Niazi, Deween Piyasena, Abdul A. Arif, Jean Wong, Ricardo S. Osorio, Clodagh M. Ryan and Frances Chung

    Citation: BMC Neurology 2019 19:195

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  29. Content type: Case report

    Emotional processes and responses are underestimated in stroke patients because the massive clinical picture of large hemispheric strokes often hides these symptoms. We report on a patient with peculiar unplea...

    Authors: Mariagiovanna Cantone, Giuseppe Lanza, Rita Bella, Giovanni Pennisi, Paola Santalucia, Placido Bramanti and Manuela Pennisi

    Citation: BMC Neurology 2019 19:193

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  30. Content type: Research article

    Neurological disorders are the most common cause of morbidity and mortality in developing countries. Available evidence on urban–rural differences on neurological diseases is scare in such countries. Our study...

    Authors: Safia Awan, Alam Ibrahim Siddiqi, Ahmed Asif, Naveeduddin Ahmed, Hazim Brohi, Sajad Jalbani and Mohammad Wasay

    Citation: BMC Neurology 2019 19:192

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  31. Content type: Research article

    We studied the efficacy and safety of a second dose of lasmiditan for acute treatment of migraine.

    Authors: Li Shen Loo, Brian M. Plato, Ira M. Turner, Michael G. Case, Joel Raskin, Sherie A. Dowsett and John H. Krege

    Citation: BMC Neurology 2019 19:191

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  32. Content type: Case report

    Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod.

    Authors: Tim Sinnecker, Jeffrie Hadisurya, Tilman Schneider-Hohendorf, Nicholas Schwab, Karsten Wrede, Oliver Gembruch, Ralf Gold, Kerstin Hellwig, Sara Pilgram-Pastor, Ortwin Adams, Philipp Albrecht, Hans-Peter Hartung, Orhan Aktas and Markus Kraemer

    Citation: BMC Neurology 2019 19:190

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  33. Content type: Case report

    Lumbosacral lipomas (LLs) may remain asymptomatic or lead to progressive neurological deterioration. However, sudden neurological deterioration is a rare and severe event. Herein, we report rare occurrences of...

    Authors: Luca Massimi, Thailane Maria Feitosa Chaves, François Yves Legninda Sop, Paolo Frassanito, Gianpiero Tamburrini and Massimo Caldarelli

    Citation: BMC Neurology 2019 19:189

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  34. Content type: Case report

    Presenilin-1 (PSEN1) is one of the causative genes for early onset Alzheimer’s disease (EOAD). Recently, emerging studies reported several novel PSEN1 mutations among Asian. We describe a male with EOAD had a ...

    Authors: Vo Van Giau, Jung-Min Pyun, Jeewon Suh, Eva Bagyinszky, Seong Soo A. An and Sang Yun Kim

    Citation: BMC Neurology 2019 19:188

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  35. Content type: Research article

    Stroke is the second-leading global cause of death behind heart disease in 2013 and is a major cause of permanent disability. The burden of stroke in terms of mortality, morbidity and disability is increasing ...

    Authors: Ginenus Fekadu, Legese Chelkeba and Ayantu Kebede

    Citation: BMC Neurology 2019 19:187

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  36. Content type: Research article

    The topographic location of acute pontine infarction is associated with clinical syndromes and prognosis. Previous studies focused on isolated pontine infarction, but the topographic location of unisolated pon...

    Authors: Jiehong Huang, Zhihua Qiu, Piansi Zhou, Jianming Li, Yingxin Chen, Ruiyun Huang, Chujing Li, Xilin Ouyang, Huazhuo Feng, Hanqing Xu, Dezhi Liu, Zheng Dai, Juehua Zhu, Xinfeng Liu, Hongbing Chen and Yongjun Jiang

    Citation: BMC Neurology 2019 19:186

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  37. Content type: Research article

    Interleukin 36 (IL-36) cytokines belong to the IL-1 family and play an important role in some autoimmune diseases. However, the relationship between IL-36 and neuromyelitis optica spectrum disorders (NMOSD) re...

    Authors: Chun-Sheng Yang, Qiu xia Zhang, Yu Deng, Bing jie Zhou, Lin jie Zhang, Li min Li, Yuan Qi, Jing Wang, Li Yang and Fu-Dong Shi

    Citation: BMC Neurology 2019 19:185

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  38. Content type: Case report

    Pembrolizumab is an immune-checkpoints inhibitor that enhances the immune response against cancer cells and therefore is useful for the treatment of several carcinomas. However, pembrolizumab sometimes perturb...

    Authors: Hikaru Kamo, Taku Hatano, Kazuaki Kanai, Nozomi Aoki, Daiki Kamiyama, Kazumasa Yokoyama, Masashi Takanashi, Yuri Yamashita, Yasushi Shimo and Nobutaka Hattori

    Citation: BMC Neurology 2019 19:184

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  39. Content type: Research article

    Stroke is the second-leading global cause of death behind heart disease in 2013 and is a major cause of permanent disability. The burden of stroke in terms of mortality, morbidity and disability is increasing ...

    Authors: Ginenus Fekadu, Legese Chelkeba and Ayantu Kebede

    Citation: BMC Neurology 2019 19:183

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  40. Content type: Case report

    Hypothalamic lesions, such as tumors and demyelinating diseases, reportedly cause abnormal sleepiness. However, stroke involving the hypothalamus has rarely been described. Here, we report a patient with infar...

    Authors: Takeo Matsubara, Keisuke Suzuki, Akiko Kawasaki, Masayuki Miyamoto, Madoka Okamura, Takashi Kanbayashi, Hidehiro Takekawa, Toshiki Nakamura, Yuji Watanabe, Masanori Matsubara and Koichi Hirata

    Citation: BMC Neurology 2019 19:182

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  41. Content type: Research article

    Optimizing thrombolytic therapy is vital for improving stroke outcomes. We aimed to develop standardized thrombolysis conditions to evaluate the efficacy of tenecteplase (TNK) compared to the current gold stan...

    Authors: Tobias Frühwald, Ulrich Gärtner, Nils Stöckmann, Jan-Henning Marxsen, Carolin Gramsch and Florian C. Roessler

    Citation: BMC Neurology 2019 19:181

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  42. Content type: Research article

    This study examined how intracranial large artery stenosis (ILAS), symptomatic and asymptomatic ILAS, and risk factors affect unfavorable outcome events after medical treatment in routine clinical practice.

    Authors: K. C. Chang, I. C. Chuang, Y. C. Huang, C. Y. Wu, W. C. Lin, Y. L. Kuo, T. H. Lee and S. J. Ryu

    Citation: BMC Neurology 2019 19:180

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  43. Content type: Study protocol

    Cognitive dysfunction is highly prevalent in Parkinson’s disease (PD) and a large proportion of patients eventually develops PD-related dementia. Currently, no effective treatment is available. Cognitive train...

    Authors: Tim D. van Balkom, Henk W. Berendse, Ysbrand D. van der Werf, Jos W. R. Twisk, Iris Zijlstra, Rob H. Hagen, Tanja Berk, Chris Vriend and Odile A. van den Heuvel

    Citation: BMC Neurology 2019 19:179

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  44. Content type: Research article

    B-mode and Color Doppler ultrasonography (CDUS) are the methods of choice for screening and determining the degree of Carotid artery stenosis. The evaluation of stenosis with calcification may be hampered by a...

    Authors: Estelle E. Seyman, Natan Bornstein, Eitan Auriel, Oren Cohen, Tania Nissel and Hen Hallevi

    Citation: BMC Neurology 2019 19:178

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