Articles

The role of a virtual avatar in attention and memory tasks in Rett syndrome

Since subjects with Rett syndrome (RTT) focus their attention mainly on the faces of people with whom they interact, in this study the role of a human-like smart interactive agent (an avatar) in enhancing cogn...

Authors: Rosa Angela Fabio, Giorgia Pergolizzi, Andrea Nucita, Giancarlo Iannizzotto and Tindara Caprì

Initial in-hospital heart rate is associated with three-month functional outcomes after acute ischemic stroke

Increased heart rate (HR) has been associated with stroke risk and outcomes.

Authors: Ya-Wen Kuo, Meng Lee, Yen-Chu Huang and Jiann-Der Lee

EGFR-mutant NSCLC presenting with stroke and massive systemic embolization as the first manifestation: case report

Presentation with massive systemic embolization as the initial manifestation of occult malignancy is infrequent. The standard management of cancer-related arterial thromboembolism has not yet been established.

Authors: Zheng Wang, Jiangyong Miao, Lina Wang, Ying Liu, Hui Ji, Xiangjian Zhang and Lili Cui

Low dose statins improve prognosis of ischemic stroke patients with intravenous thrombolysis

For acute ischaemic stroke patients, it is uncertain whether intravenous thrombolysis combined with statins might increase the therapeutic effect. Additionally, using high-intensity statins after thrombolysis ...

Authors: Chaohua Cui, Yanbo Li, Jiajia Bao, Shuju Dong, Lijie Gao and Li He

Serial magnetic resonance imaging changes of pseudotumor lesions in retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations: a case report

Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is an adult-onset rare monogenic microvasculopathy. Its typical neuroimaging features are punctate white matter lesio...

Authors: Yuying Yan, Shuai Jiang, Ruilin Wang, Xiang Wang, Peng Li and Bo Wu

Validity and reliability of the Georgian-language brief international cognitive assessment for multiple sclerosis (BICAMS)

Cognitive impairment is one of the common features of multiple sclerosis (MS). Despite high prevalence, cognitive decline is often overlooked by neurologists. The Brief International Cognitive Assessment for M...

Authors: Nazibrola Botchorishvili, Nino Shiukashvili, Nina Mikeladze, Ann Dzagnidze, Nino Mikava, Maia Tighashvili and Marina Janelidze

Lacosamide-induced sinus node dysfunction followed by severe agranulocytosis

Lacosamide (LCM) is the antiepileptic drug approved by the U.S. Food and Drug Administration in 2008 that facilitates slow activation of the voltage-gated sodium channels. Neutropenia and cardiac events includ...

Authors: Makoto Shibata, Reona Hoshino, Chisato Shimizu, Masayuki Sato, Natsumi Furuta and Yoshio Ikeda

Clinical Ethics Consultation in Neurology – a case series

The concept of clinical ethics consultation (CECs) was implemented to provide support in ethical controversies in clinical settings and are offered in at least every second hospital in Germany. Neurological di...

Authors: Benjamin Ilse, Bernd Alt-Epping, Albrecht Günther, Jan Liman and Alfred Simon

Recurrent epistaxis from inflamed granulated tissue and an associated pseudoaneurysm of the internal carotid artery: case report

Chronic inflamed tissue in nasal cavity is a rare complication of transsphenoidal approach (TSA). Inflamed tissue is rich in blood vessels, which can lead to frequent nosebleeds. In addition, chronic inflammat...

Authors: Ja Yoon Kim, Yong Bae Kim and Joonho Chung

The course of facial corticobulbar tract fibers in the dorsolateral medulla oblongata

The course of the corticobulbar tract (CBT) to the facial nucleus has been investigated by some previous studies. However, there are some unclear points of the course of the CBT to the facial nucleus. This stu...

Authors: Takamichi Kanbayashi and Masahiro Sonoo

Clinical characteristics and neuroimaging findings of seven patients with Dyke Davidoff Masson syndrome

DDMS is a rare disease diagnosed by clinical and radiological characteristics. But the complexity of radiological and clinical manifestations of DDMS has become a challenge diagnostically. To date, the reporte...

Authors: Bing Wang, Wentao Jiang, Weiqiang Yan, Jianhong Tian, Jianxing Xu, Yulin Li, Yanzhen Zhao, Yi Dai, Guanxun Cheng and Gangqiang Hou

Graves’ disease with anti-GQ1b antibody syndrome: a rare case report

Graves’ disease and anti-GQ1b antibody syndrome are both autoimmune diseases, and there have been few reports on whether there is a correlation between the two. In this study, we present the case of a woman wh...

Authors: Tao Liang, Zhiwei Zhou, Xiaolin Hu and Zhong Luo

Assessing migraine patients with multifocal pupillographic objective perimetry

To establish the effects of stimulating intrinsically-photosensitive retinal ganglion cells (ipRGCs) on migraine severity, and to determine if migraine produces objectively-measured visual field defects.

Authors: Eman N. Ali, Corinne F. Carle, Christian J. Lueck, Maria Kolic and Ted Maddess

Primary intracranial germ cell tumour originating from right brachium Pontis with hypertrophic Olivary degeneration: a case report

Primary right brachium pontis germinoma with hypertrophic olivary degeneration (HOD) is extremely rare. A preoperative diagnosis is challenging due to the absence of characterized clinical and neuroimaging fea...

Authors: Yanong Li, Peng Wang, Jin Feng, Jiayi Wang, Jing Zhang and Xiaoguang Qiu

Gender differences in comorbidities and risk factors in ischemic stroke patients with a history of atrial fibrillation

Atrial Fibrillation (AF) is a common cardiac arrhythmia and has been identified as a major risk factor for acute ischemic stroke (AIS). Gender differences in the disease process, causative mechanisms and outco...

Authors: Chase Rathfoot, Camron Edrissi, Carolyn Breauna Sanders, Krista Knisely, Nicolas Poupore and Thomas Nathaniel

Risk of ischaemic stroke associated with antiepileptic drugs: a population-based case-control study in Catalonia

Cerebrovascular disorders have occurred more frequently in some Central Nervous System (CNS) disorders, such as epilepsy. Some CNS drugs have been associated with increased stroke risk. Our aim was to estimate...

Authors: Maria Giner-Soriano, Josep Ramon Marsal, Ainhoa Gomez-Lumbreras and Rosa Morros

Midterm prognosis and surgical implication for clival chordomas after extended transsphenoidal tumor removal and gamma knife radiosurgery

Treating chordoma through surgery alone is often ineffective. Thus, surgery often performed with irradiation, with a reported 5-year survival rate of 60–75%. The clinical course varies, and disease rarity prev...

Authors: Yoshikazu Ogawa, Hidefumi Jokura and Teiji Tominaga

Ala97Ser transthyretin amyloidosis-associated polyneuropathy, clinical and neurophysiological profiles in a Thai cohort

Ala97Ser transthyretin amyloidosis-associated polyneuropathy (ATTRA97S-PN) is a rare form of inherited polyneuropathy, usually manifesting with late-onset (> 50) progressive polyneuropathy. This mutation is mo...

Authors: Nath Pasutharnchat, Chamaiporn Taychargumpoo, Yongkasem Vorasettakarnkij and Jakkrit Amornvit

Neurological manifestations of polyarteritis nodosa: a tour of the neuroaxis by case series

Heterogenous central nervous system (CNS) neurologic manifestations of polyarteritis nodosa (PAN) are underrecognized. We review three cases of patients with PAN that illustrate a range of nervous system patho...

Authors: Cathra Halabi, Erika K. Williams, Ramin A. Morshed, Mauro Caffarelli, Christine Anastasiou, Tarik Tihan, Daniel Cooke, Adib A. Abla, Christopher F. Dowd, Vinil Shah, Sharon Chung and Megan B. Richie

Crossed brainstem syndrome revealing bleeding brainstem cavernous malformation: an illustrative case

Since the nineteenth century, a great variety of crossed brainstem syndromes (CBS) have been described in the medical literature. A CBS typically combines ipsilateral cranial nerves deficits to contralateral l...

Authors: Nathan Beucler, Sébastien Boissonneau, Aurélia Ruf, Stéphane Fuentes, Romain Carron and Henry Dufour

Autoimmune encephalitis in a South Asian population

Autoimmune encephalitis (AE) is now considered a main, potentially curable cause of encephalitis, but remains conspicuously underreported from South Asia. We studied the clinical characteristics in relation to...

Authors: Nilanka Wickramasinghe, Dhanushka Dasanayake, Neelika Malavige, Rajiva de Silva and Thashi Chang

MRI-based early diagnosis: a diabetic Charcot spine case report

Spinal neuroarthropathy (SNA), also known as Charcot spine, is an uncommon aggressive arthropathy, secondary to loss of proprioceptive and nociceptive feedback from the spine. A diagnosis of SNA is frequently ...

Authors: Barbara Limberger Nedel, Juliana Avila Duarte and Fernando Gerchman

Accelerating diagnosis of Parkinson’s disease through risk prediction

Characterization of prediagnostic Parkinson’s Disease (PD) and early prediction of subsequent development are critical for preventive interventions, risk stratification and understanding of disease pathology. ...

Authors: William Yuan, Brett Beaulieu-Jones, Richard Krolewski, Nathan Palmer, Christine Veyrat-Follet, Francesca Frau, Caroline Cohen, Sylvie Bozzi, Meaghan Cogswell, Dinesh Kumar, Catherine Coulouvrat, Bruno Leroy, Tanya Z. Fischer, S. Pablo Sardi, Karen J. Chandross, Lee L. Rubin…

Learning to play golf for elderly people with subjective memory complaints: feasibility of a single‐blinded randomized pilot trial

Subjective Memory Complaints (SMC) in elderly people due to preclinical Alzheimer’s Disease may be associated with dysregulation of the Kynurenine Pathway (KP), with an increase in neurotoxic metabolites that ...

Authors: Julia K. Stroehlein, Solveig Vieluf, Philipp Zimmer, Alexander Schenk, Max Oberste, Christian Goelz, Franziska van den Bongard and Claus Reinsberger

First report of Bickerstaff’s brainstem encephalitis caused by Salmonella Dublin: a case report

Diseases caused by nontyphoid Salmonella can range from mild, to self-limiting gastroenteritis and severe invasive infection. Relatively rarely, Salmonella may cause severe encephalopathy.

Authors: Jiangbo Xie, Tingting Zhang and Tao Liu

Endovascular treatment of vertebral and basilar artery aneurysms with low-profile visualized intraluminal support device

The Low-profile Visualized Intraluminal Support (LVIS) device is a self-expanding, nitinol, single-braid, closed-cell device that was recently developed for endovascular embolization of intracranial aneurysms....

Authors: Quanlong Hong, Wenqiang Li, Jing Ma, Peng Jiang and Yisen Zhang

Identification of upregulated NF-κB inhibitor alpha and IRAK3 targeting lncRNA following intracranial aneurysm rupture-induced subarachnoid hemorrhage

This study was performed to identify genes and lncRNAs involved in the pathogenesis of subarachnoid hemorrhage (SAH) from ruptured intracranial aneurysm (RIA).

Authors: Wei Leng, Dan Fan, Zhong Ren and Qiaoying Li

Time course of outcome in poor grade subarachnoid hemorrhage patients: a longitudinal retrospective study

Neurological outcome and mortality of patients suffering from poor grade subarachnoid hemorrhage (SAH) may have changed over time. Several factors, including patients’ characteristics, the presence of hydrocep...

Authors: Elisa Gouvêa Bogossian, Daniela Diaferia, Andrea Minini, Narcisse Ndieugnou Djangang, Marco Menozzi, Lorenzo Peluso, Filippo Annoni, Jacques Creteur, Sophie Schuind, Olivier Dewitte and Fabio Silvio Taccone

BRAF^non-V600E more frequently co-occurs with IDH1/2 mutations in adult patients with gliomas than in patients harboring BRAF^V600E but without a survival advantage

The effects of BRAF^non-V600E and BRAF^V600E on the outcomes and the molecular characteristics of adult glioma patients are unknown and need to be explored, although BRAF^V600E has been extensively studied in pediat...

Authors: Wei Wang, Maode Wang, Haitao Jiang, Tuo Wang and Rong Da

Prevalence and profile of nocturnal disturbances in Chinese patients with advanced-stage Parkinson’s disease: a cross-sectional epidemiology study

The impact of nocturnal disturbance (ND) in Parkinson’s disease on quality of life of patients in Western Countries is increasingly understood. Our study aimed to investigate ND prevalence and its quality of l...

Authors: Guiying He, Chun-Feng Liu, Qinyong Ye, Zhenguo Liu, Miao Jin, Huifang Shang, Ling Chen, Houzhen Tuo, Hong Jiang, Jifu Cai, Kalpesh Joshi, James Cooper, Lu Zi and Shengdi Chen

Explaining the facilitators of quality of life in patients with multiple sclerosis: a qualitative study

In patients with multiple sclerosis (MS), the disease’s complications and manifestations affect a person’s ability to function normally and leads to further disruptions in their education, family life, job opp...

Authors: Atefeh Homayuni, Sedigheh Abedini, Zahra Hosseini, Masoud Etemadifar and Amin Ghanbarnejad

Correction to: Post-traumatic cerebral fat embolism syndrome with a favourable outcome: a case report

Authors: Wei Wang, Weibi Chen, Yan Zhang, Yingying Su and Yuping Wang

Prognostic value of the neutrophil-to-lymphocyte ratio in acute ischemic stroke patients treated with intravenous thrombolysis: a systematic review and meta-analysis

The relationship between the neutrophil-to-lymphocyte ratio (NLR) and poor prognostics in acute ischemic stroke (AIS) patients who receive intravenous thrombolysis (IVT) remains controversial. The purpose of t...

Authors: Chengbing Wang, Qian Zhang, Mingwei Ji, Jing Mang and Zhongxin Xu

The role of surgical resection in primary central nervous system lymphoma: a single-center retrospective analysis of 70 patients

The aim of this study was to evaluate the effect of surgical resection and stereotactic biopsy on the complication rate, progression-free survival (PFS) and overall survival (OS) of 70 patients diagnosed at a ...

Authors: Shiqiang Wu, Junwen Wang, Weihua Liu, Feng Hu, Kai Zhao, Wei Jiang, Ting Lei and Kai Shu

Agreement between neuroimages and reports for natural language processing-based detection of silent brain infarcts and white matter disease

There are numerous barriers to identifying patients with silent brain infarcts (SBIs) and white matter disease (WMD) in routine clinical care. A natural language processing (NLP) algorithm may identify patient...

Authors: Lester Y. Leung, Sunyang Fu, Patrick H. Luetmer, David F. Kallmes, Neel Madan, Gene Weinstein, Vance T. Lehman, Charlotte H. Rydberg, Jason Nelson, Hongfang Liu and David M. Kent

Ipsilateral hypoperfusion caused by intracerebral steal phenomenon after carotid artery stenting: a case report

Abnormal hypoperfusion on the surgical side after carotid artery stenting is rare. Neurological deterioration caused by it is deceptive, which can easily lead to misdiagnosis. The mechanism of hypoperfusion ha...

Authors: Zhizhong Yan, Zhonghua Shi, Yuhai Wang, Chunlei Zhang, Huize Liu, Jin Cai and Xin Zhang

Study of the collagen type VI alpha 3 (COL6A3) gene in Parkinson’s disease

To date, the genetic contribution to Parkinson’s disease (PD) remains unclear. Mutations in the collagen type VI alpha 3 (COL6A3) gene were recently identified as a cause of isolated dystonia. Since PD and dyston...

Authors: Chong-Yao Jin, Ran Zheng, Zhi-Hao Lin, Nai-Jia Xue, Ying Chen, Ting Gao, Yi-Qun Yan, Yi Fang, Ya-Ping Yan, Xin-Zhen Yin, Jun Tian, Jia-Li Pu and Bao-Rong Zhang

Risk factors related balance disorder for patients with dizziness/vertigo

When dizziness/vertigo patients presented with balance disorder, it will bring severe morbidity. There is currently lack of research to explore risk factor related balance disorder in dizziness patients, espec...

Authors: Zhentang Cao, Cuiting Zhu, Yanan Zhou, Yan Wang, Meimei Chen, Yi Ju and Xingquan Zhao

Morvan syndrome associated with LGI1 antibody: a case report

Morvan syndrome (MoS) is a rare autoimmune syndrome associated with antibodies against two kinds of potassium channel proteins, contactin associated protein-like 2 (CASPR2) and leucine-rich glioma inactivated ...

Authors: Shui-Jing Zhang, Yan-Yan Xue, Hao Yu and Qing-Qing Tao

Headache from clinically confirmed hemicrania continua arising from the sternocleidomastoid muscle: a case report

A patient with a history of cluster headaches, now in remission, presented with confirmed hemicrania continua that resolved with a local anaesthetic injection into the Sternocleidomastoid (SCM) muscle. To the ...

Authors: Osnat Wende and Shira Markowitz

Rituximab and risk of COVID-19 infection and its severity in patients with MS and NMOSD

Choosing a safe disease modifying therapy during the COVID-19 pandemic is challenging. This case series study was conducted to determine the incidence rate and the course of Covid-19 infection in MS/NMOSD pati...

Authors: Sara Esmaeili, Mohammad Hossein Abbasi, Meysam Abolmaali, Mohammad Mojtahed, Seyedeh Niloufar Rafiei Alavi, Sevim Soleimani, Mahisa Mokhtari, Jaber Hatam, Samaneh Tanhapour Khotbehsara, Mohammad Reza Motamed, Mohammad Taghi Joghataei, Zahra Mirzaasgari and Mehdi Moghaddasi

An age-dependent outcome analysis of microvascular decompression and percutaneous thermocoagulation in trigeminal neuralgia

Trigeminal neuralgia (TN) is a severe pain condition and the most common facial neuralgia. While microvascular decompression (MVD) presents an excellent treatment in neurovascular compression cases, percutaneo...

Authors: Naureen Keric, Darius Kalasauskas, Sophia L. Kreth, Martin B. Glaser, Harald Krenzlin, Sven R. Kantelhardt and Florian Ringel

Camptocormia in patients with multiple system atrophy at different disease durations: frequency and related factors

Camptocormia is common in patients with multiple system atrophy (MSA). The current study was aimed at assessing the frequency of camptocormia and its related factors in MSA patients with different disease dura...

Authors: Ling Yu Zhang, Bei Cao, Qian-Qian Wei, Ru Wei Ou, Bi Zhao, Jing Yang, Ying Wu and Hui Fang Shang

Novel manifestations of Warburg micro syndrome type 1 caused by a new splicing variant of RAB3GAP1: a case report

The present study aimed to determine the underlying genetic factors causing the possible Warburg micro syndrome (WARBM) phenotype in two Iranian patients.

Authors: Raziyeh Khalesi, Ehsan Razmara, Golareh Asgaritarghi, Ali Reza Tavasoli, Yasser Riazalhosseini, Daniel Auld and Masoud Garshasbi

Hemisensory syndrome: Hyperacute symptom onset and age differentiates ischemic stroke from other aetiologies

An important cause of hemisensory syndrome is ischemic stroke. However, the diagnostic yield of neuroradiological imaging on hemisensory syndrome is low. Therefore, we aim to describe patients hospitalized wit...

Authors: Pei Xuan Koh, Joanna Ti, Seyed Ehsan Saffari, Zhen Yu Isis Claire Lim and Tianming Tu

Traumatic ischemic injury in a top of the basilar distribution: a case report

Top of the basilar syndrome is a rare, heterogeneous disorder that has previously only been described in the setting of acute ischemic stroke in predominantly elderly patients. We present the first reported ca...

Authors: Mihir Gupta, Anudeep Yekula, David Barba, J. Scott Pannell and Jeffrey Tomlin

Nerve transfer surgery in spinal cord injury: online information sharing

Nerve transfer to improve upper extremity function in persons with cervical spinal cord injury (SCI) is a new reconstructive option, and has led to more people seeking and sharing surgical information and expe...

Authors: Syena Moltaji, Christine B. Novak and Jana Dengler

Effectiveness of paranasal air suction on acute migraine using portable air sucker – a randomized, double blind study

Migraine is a primary headache disorder and is the most common disabling primary headache disorder that occurs in children and adolescents. A recent study showed that paranasal air suction can provide relief t...

Authors: S. M. R. Bandara, S. Samita, A. M. Kiridana and H. M. M. T. B. Herath

Efficacy of galcanezumab in patients with migraine who did not benefit from commonly prescribed preventive treatments

Galcanezumab is a calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) indicated for the preventive treatment of migraine. While galcanezumab has demonstrated efficacy in patients who did not respo...

Authors: Dulanji K. Kuruppu, Joshua Tobin, Yan Dong, Sheena K. Aurora, Laura Yunes-Medina and A. Laine Green

Effectiveness of medication in cluster headache

The aim of this work is to analyze the reports on cluster headache attacks collected online in the citizen science project CLUE with respect to the effectiveness of drugs taken during the attacks. The collecti...

Authors: Johannes Drescher, Andreas Khouri, Tina Katharina Amann, Charly Gaul, Peter Kropp, Yannic Siebenhaar and Jörg Scheidt