Articles

A generic outcome assessment of mobility capacity in neurorehabilitation: measurement properties of the de Morton Mobility Index

Mobility capacity is a key outcome domain in neurorehabilitation. The de Morton Mobility Index (DEMMI), an established and generic outcome assessment of mobility capacity in older patients, is promising for us...

Authors: Tobias Braun, Detlef Marks, Christian Thiel and Christian Grüneberg

A different point of view: the evaluation of motor imagery perspectives in patients with sensorimotor impairments in a longitudinal study

Motor imagery (MI) has been successfully applied in neurological rehabilitation. Little is known about the spontaneous selection of the MI perspectives in patients with sensorimotor impairments. What perspecti...

Authors: Szabina Gäumann, Rahel Sarah Gerber, Zorica Suica, Jasmin Wandel and Corina Schuster-Amft

A case report of secondary neurolymphomatosis showing selective nerve infiltration and massive lumbar plexus enlargement

Neurolymphomatosis (NL) is a rare manifestation of malignant lymphoma that shows selective infiltration to the peripheral nervous system primarily or secondarily. We report a patient with secondary NL caused b...

Authors: Mai Hamaguchi, Norito Kokubun, Hadzki Matsuda, Hiroki Onuma, Reika Aoki, Wataru Takahashi, Kinuko Mitani and Keisuke Suzuki

Differential disease phenotypes and progression in relapsing–remitting multiple sclerosis: comparative analyses of single Canadian and Saudi Arabian clinics

Relapsing–remitting multiple sclerosis (RR-MS) phenotypes differ widely although the variables contributing to this heterogeneity remain uncertain. To assess geographic and ethnic effects on RR-MS phenotypes, ...

Authors: M. Alluqmani, W. Roda, M. Qqrmli, G. Blevins, F. Giuliani and C. Power

Effectiveness comparisons of drug therapies for postoperative aneurysmal subarachnoid hemorrhage patients: network meta‑analysis and systematic review

To compare the effectiveness of various drug interventions in improving the clinical outcome of postoperative patients after aneurysmal subarachnoid hemorrhage (aSAH) and assist in determining the drugs of def...

Authors: Wanli Yu, Yizhou Huang, Xiaolin Zhang, Huirong Luo, Weifu Chen, Yongxiang Jiang and Yuan Cheng

Atypical presentation of Charcot-Marie-Tooth disease type 1C with a new mutation: a case report

Charcot-Marie-Tooth 1C (CMT1C) is a rare form of dominantly inherited CMT1 neuropathy caused by a mutated gene encoding lipopolysaccharide-induced tumour necrosis alpha factor (LITAF).

Authors: Monika Turčanová Koprušáková, Milan Grofik, Ema Kantorová, Petra Jungová, Ján Chandoga, Martin Kolisek, Peter Valkovič, Matej Škorvánek, Rafal Ploski, Egon Kurča and Štefan Sivák

Inner diameters of the normal carotid arteries measured using three-dimensional digital subtraction catheter angiography: a retrospective analysis

To obtain normal ranges for the inner diameters of the carotid arteries.

Authors: Qingjing Tan, Chao Qin, Junwei Yang, Tianbao Wang, Haohai Lin, Cuiting Lin and Xiangren Chen

Optimizing telemedical care in neurological outpatients by characterizing the patients’ needs in the physician–patient relationship—content analysis of guideline-based interviews

The use of new concepts in patient care, such as video-consultations, reminder systems, and online evaluation portals, is becoming increasingly important in the physician–patient relationship and outpatient ca...

Authors: Till Hamann, Stella Lemke, Peter Kropp, Florian Rimmele, Tim P. Jürgens and Fabian Frielitz

The thalamus in trigeminal neuralgia: structural and metabolic abnormalities, and influence on surgical response

Medically-refractory trigeminal neuralgia (TN) can be treated successfully with operative intervention, but a significant proportion of patients are non-responders despite undergoing technically successful sur...

Authors: Hayden Danyluk, Jennifer Andrews, Rohit Kesarwani, Peter Seres, Robert Broad, B. Matt Wheatley and Tejas Sankar

Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population

Visual rating of medial temporal lobe atrophy (MTA) is often performed in conjunction with dementia workup. Most prior studies involved patients with known or probable Alzheimer’s disease (AD). This study inve...

Authors: Anna Molinder, Doerthe Ziegelitz, Stephan E. Maier and Carl Eckerström

Autosomal recessive hyper-IgE syndrome caused by DOCK8 gene mutation with new clinical features: a case report

Autosomal recessive hyper-IgE syndrome (AR-HIES) caused by DOCK8 gene is a rare immunodeficiency disease, the main clinical manifestations include recurrent Eczema-like rash, skin and lung abscesses, accompanied ...

Authors: Jing Yang and Yan Liu

Intraoperative monitoring of visual evoked potentials in patients undergoing transsphenoidal surgery for pituitary adenoma: a systematic review

Transsphenoidal surgery is the gold standard for pituitary adenoma resection. Although rare, a serious complication of surgery is worsened vision post-operatively.

Authors: Farizeh Jashek-Ahmed, Ivan Cabrilo, Jarnail Bal, Brett Sanders, Joan Grieve, Neil L. Dorward and Hani J. Marcus

Rationale and design to evaluate the PRIME Parkinson care model: a prospective observational evaluation of proactive, integrated and patient-centred Parkinson care in The Netherlands (PRIME-NL)

Culminating evidence shows that current care does not optimally meet the needs of persons with parkinsonism, their carers and healthcare professionals. Recently, a new model of care was developed to address th...

Authors: Jan H. L. Ypinga, Angelika D. Van Halteren, Emily J. Henderson, Bastiaan R. Bloem, Agnes J. Smink, Emma Tenison, Marten Munneke, Yoav Ben-Shlomo and Sirwan K. L. Darweesh

Mobile intraoperative CT-assisted frameless stereotactic biopsies achieved single-millimeter trajectory accuracy for deep-seated brain lesions in a sample of 7 patients

Brain biopsies are crucial diagnostic interventions, providing valuable information for treatment and prognosis, but largely depend on a high accuracy and precision. We hypothesized that through the combinatio...

Authors: Oliver Bichsel, Markus F. Oertel and Lennart H. Stieglitz

COVID-19 social distancing: negative effects on people with Parkinson disease and their associations with confidence for self-management

The purpose of this study was to describe the effects of COVID-19 social distancing on the function, health, and well-being of people with Parkinson disease (PD), and test the association of these effects with...

Authors: Galit Yogev-Seligmann and Michal Kafri

Weather conditions associated with subarachnoid hemorrhage: a multicenter case-crossover study

Most spontaneous subarachnoid hemorrhages (SAH) occur unexpectedly and independently of classical risk factors. In the light of increasing climate variability and change, we investigated weather and rapid weat...

Authors: Michael Kockler, Peter Schlattmann, Mario Walther, Georg Hagemann, Philipp Nils Becker, Steffen Rosahl, Otto W. Witte, Matthias Schwab and Florian Rakers

Maximum resection and immunotherapy improve glioblastoma patient survival: a retrospective single-institution prognostic analysis

Glioblastoma (GBM) is a refractory disease with a poor prognosis and various methods, including maximum resection and immunotherapy, have been tested to improve outcomes. In this retrospective study we analyze...

Authors: Eiichi Ishikawa, Narushi Sugii, Masahide Matsuda, Hidehiro Kohzuki, Takao Tsurubuchi, Hiroyoshi Akutsu, Shingo Takano, Masashi Mizumoto, Hideyuki Sakurai and Akira Matsumura

Wall shear stress gradient is independently associated with middle cerebral artery aneurysm development: a case-control CFD patient-specific study based on 77 patients

Previously published computational fluid dynamics (CFD) studies regarding intracranial aneurysm (IA) formation present conflicting results. Our study analysed the involvement of the combination of high wall sh...

Authors: Mikołaj Zimny, Edyta Kawlewska, Anna Hebda, Wojciech Wolański, Piotr Ładziński and Wojciech Kaspera

Mapping causal circuit dynamics in stroke using simultaneous electroencephalography and transcranial magnetic stimulation

Motor impairment after stroke is due not only to direct tissue loss but also to disrupted connectivity within the motor network. Mixed results from studies attempting to enhance motor recovery with Transcrania...

Authors: Camarin E. Rolle, Fiona M. Baumer, Joshua T. Jordan, Ketura Berry, Madelleine Garcia, Karen Monusko, Hersh Trivedi, Wei Wu, Russell Toll, Marion S. Buckwalter, Maarten Lansberg and Amit Etkin

Patients and general practitioners assessment of the main outcomes employed in the acute and preventive treatment of migraine: a cross sectional study

We aim to describe and compare patients and general practitioners’ opinions about the different variables related to acute and preventive treatment for migraine.

Authors: Javier Trigo-López, Ángel Luis Guerrero-Peral, Álvaro Sierra, Enrique Martínez-Pías, María Gutiérrez-Sánchez, Elizabeth Huzzey and David García-Azorín

Case series of idiopathic intracranial hypertension in three patients with immune-complex glomerulonephritis

Idiopathic intracranial hypertension (IIH) is defined by an increased cerebrospinal fluid pressure in the absence of inflammation, structural obstructions, or mass lesions. Although the underlying pathogenesis...

Authors: Felix Fischbach, Anne Deborah Scholz-Hehn, Christian Gerloff and Monika Pötter-Nerger

Myasthenia gravis associated with renal cell carcinoma: a paraneoplastic syndrome or just a coincidence

Myasthenia gravis (MG) can occur as a paraneoplastic phenomenon associated with thymoma. The association of MG with renal cell carcinoma (RCC) is not clear. Herein, we describe six cases of MG associated with ...

Authors: Yiming Zheng, Jingjing Luo, Haiqiang Jin, Ran Liu, Hongjun Hao and Feng Gao

Treatment of spasticity in children and adolescents with cerebral palsy in Northern Europe: a CP-North registry study

Spasticity is present in more than 80% of the population with cerebral palsy (CP). The aim of this study was to describe and compare the use of three spasticity reducing methods; Botulinum toxin-A therapy (BTX...

Authors: Gunnar Hägglund, Sandra Julsen Hollung, Matti Ahonen, Guro L. Andersen, Guðbjörg Eggertsdóttir, Mark S. Gaston, Reidun Jahnsen, Ira Jeglinsky-Kankainen, Kirsten Nordbye-Nielsen, Ilaria Tresoldi and Ann I. Alriksson-Schmidt

Clinical features and outcome of Guillain–Barre syndrome in Saudi Arabia: a multicenter, retrospective study

Guillain–Barre syndrome (GBS) is an inflammatory polyradiculoneuropathy characterized by rapidly evolving weakness and areflexia, reaching nadir within 4 weeks. Data on the characteristic of GBS in Saudi Arabi...

Authors: Mohammed H. Alanazy, Sawsan S. Bakry, Afnan Alqahtani, Norah S. AlAkeel, Naael Alazwary, Afag M. Osman, Rania A. Mustafa, Talal M. Al-Harbi, Sameeh O. Abdulmana, Aimee C. Amper, Yousef Aldughaythir, Abdulrahman S. Ali, Seraj Makkawi, Alaa Maglan, Loujen Alamoudi, Feras Alsulaiman…

Association of serum levels of antibodies against ALDOA and FH4 with transient ischemic attack and cerebral infarction

Ischemic stroke, including transient ischemic attack (TIA) and acute-phase cerebral infarction (aCI), is a serious health problem in the aging society. Thus, this study aimed to identify TIA and aCI biomarkers.

Authors: Hao Wang, Hao Lu, Xiao-Meng Zhang, Ken-ichiro Goto, Eiichi Kobayashi, Yoichi Yoshida, Akihiko Adachi, Tomoo Matsutani, Yasuo Iwadate, Seiichiro Mine, Toshio Machida, Mizuki Sata, Kazumasa Yamagishi, Hiroyasu Iso, Norie Sawada, Shoichiro Tsugane…

Coexistence of neuronal intranuclear inclusion disease and amyotrophic lateral sclerosis: an autopsy case

Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease. Pathologically, it is characterized by eosinophilic hyaline intranuclear inclusions in the cells of the visceral organs as we...

Authors: Atsuhiko Sugiyama, Takahiro Takeda, Mizuho Koide, Hajime Yokota, Hiroki Mukai, Yoshihisa Kitayama, Kazumoto Shibuya, Nobuyuki Araki, Ai Ishikawa, Sagiri Isose, Kimiko Ito, Kazuhiro Honda, Yoshitaka Yamanaka, Terunori Sano, Yuko Saito, Kimihito Arai…

Low mechano-afferent fibers reduce thermal pain but not pain intensity in CRPS

Human hairy (not glabrous skin) is equipped with a subgroup of C-fibers, the C-tactile (CT) fibers. Those do not mediate pain but affective aspects of touch. CT-fiber-activation reduces experimental pain if th...

Authors: Kathrin Habig, Gothje Lautenschläger, Hagen Maxeiner, Frank Birklein, Heidrun H. Krämer and Susann Seddigh

Construction of a risk prediction model for Alzheimer’s disease in the elderly population

Dementia is one of the greatest global health and social care challenges of the twenty-first century. The etiology and pathogenesis of Alzheimer’s disease (AD) as the most common type of dementia remain unknow...

Authors: Lingling Wang, Ping Li, Ming Hou, Xiumin Zhang, Xiaolin Cao and Hongyan Li

Evaluation of the hemostatic effect of a combination of hemostatic agents and fibrin glue in a rabbit venous hemorrhage model

In neurosurgery, it is important to use local hemostatic agents. We have explored a more powerful method of hemostasis by the combination of commercially available hemostatic agents with fibrin glue in the hop...

Authors: Katsumi Takizawa, Daiki Okazaki, Yoshitaka Takegawa, Yuki Koga, Masataka Sagata, Kenichi Michishita and Noriko Shinya

National registry for amyotrophic lateral sclerosis: a systematic review for structuring population registries of motor neuron diseases

This article comprises a systematic review of the literature that aims at researching and analyzing the frequently applied guidelines for structuring national databases of epidemiological surveillance for moto...

Authors: Ingridy Barbalho, Ricardo Valentim, Mário Dourado Júnior, Daniele Barros, Hércules Pedrosa Júnior, Felipe Fernandes, César Teixeira, Thaísa Lima, Jailton Paiva and Danilo Nagem

Comparison of the curative effect and prognosis of stereotactic drainage and conservative treatment for moderate and small basal ganglia haemorrhage

Minimally invasive surgery has achieved good results in the treatment of cerebral haemorrhage.However, no large-scale clinical study has demonstrated that surgical treatment of cerebral haemorrhages less than ...

Authors: Xin Huang, Lai Jiang, Shaojun Chen, Gang Li, Wanxi Pan, Lei Peng and Ziwei Yan

A case report of atypical hemiplegic migraine with nonheadache onset in a Chinese child

Hemiplegic migraine (HM) is an uncommon subtype of migraine with aura including motor weakness. The core symptoms of HM are headache and motor weakness. However, we report a rare case of atypical HM with nonhe...

Authors: Hui Chen, Xiaolan Sun, Ruiyan Wang, Zhaoshi Yi, Zhixin Huang, Jihua Xie, Xiongying Yu, Yong Chen and Jianmin Zhong

How to forget a “traumatic” experience: a case report of transient global amnesia after nasopharyngeal swab for Coronavirus disease 19

Transient global amnesia (TGA) is a clinical syndrome characterized by a temporary short-term memory loss with inability to retain new memories, usually lasting 2 to 8 h. TGA may be related to several medical ...

Authors: Sabrina Ravaglia, Antonio Zito, Lara Ahmad and Isabella Canavero

A Japanese case of oculopharyngeal muscular dystrophy (OPMD) with PABPN1 c.35G > C; p.Gly12Ala point mutation

Oculopharyngeal muscular dystrophy (OPMD) is a late-onset muscular dystrophy characterised by slowly progressive ptosis, dysphagia, and proximal limb muscle weakness. A common cause of OPMD is the short expans...

Authors: Yo-suke Nishii, Yu-ichi Noto, Rei Yasuda, Takamasa Kitaoji, Shinji Ashida, Eijirou Tanaka, Narihiro Minami, Ichizo Nishino and Toshiki Mizuno

Steroid responsive cavernous sinus syndrome due to Rosai-Dorfman disease: beyond Tolosa-Hunt syndrome – a case report

The term “Tolosa-Hunt syndrome” (THS) has been used to refer to painful ophthalmoplegia associated with nonspecific inflammation of the cavernous sinus and many processes can result in a similar clinical pictu...

Authors: Paulo Ribeiro Nóbrega, Pedro Gustavo Barros Rodrigues, Isabelle de Sousa Pereira, Carolina de Figueiredo Santos, Gunter Gerson, José Arnaldo Motta de Arruda, José Wagner Leonel Tavares Júnior, Pablo Picasso de Araújo Coimbra and Pedro Braga-Neto

Development of clinical guidelines for service provision of functional electrical stimulation to support walking: mixed method exploration of stakeholder views

Over the past 20 years Functional Electrical Stimulation (FES) has grown in clinical use to support walking in people with lower limb weakness or paralysis due to upper motor neuron lesions. Despite growing co...

Authors: C Bulley, C Meagher, T Street, A Adonis, C Peace, C Singleton and J. Burridge

Home-based light therapy for fatigue following acquired brain injury: a pilot randomized controlled trial

Fatigue and sleep disturbance are debilitating problems following brain injury and there are no established treatments. Building on demonstrated efficacy of blue light delivered via a lightbox in reducing fati...

Authors: Laura J. Connolly, Shantha M. W. Rajaratnam, Jade M. Murray, Gershon Spitz, Steven W. Lockley and Jennie L. Ponsford

Sex and age differences in isolated traumatic brain injury: a retrospective observational study

Among the many factors that may influence traumatic brain injury (TBI) progression, sex is one of the most controversial. The objective of this study was to investigate sex differences in TBI-associated morbid...

Authors: Sanae Hosomi, Tetsuhisa Kitamura, Tomotaka Sobue, Hiroshi Ogura and Takeshi Shimazu

Limb-shaking TIA: a case of cerebral hypoperfusion in severe cerebrovascular disease in a young adult

Limb-shaking transient ischaemic attacks (TIAs) are an under recognised presentation of severe cerebrovascular disease resulting from cerebral hypoperfusion. Patients present with jerking, transitory limb move...

Authors: Tom E. Richardson, Paul Beech and Geoffrey C. Cloud

The clinical and prognostic values of optic nerve sheath diameter and optic nerve sheath diameter/eyeball transverse diameter ratio in comatose patients with supratentorial lesions

The optic nerve sheath diameter (ONSD) and ONSD/eyeball transverse diameter (ETD) ratio have been proven to be correlated with intracranial pressure. This study aimed to evaluate the prognostic roles of ONSD a...

Authors: Sha Zhu, Chao Cheng, Dianjiang Zhao, Yuanli Zhao, Xianzeng Liu and Jun Zhang

The significance of the oxidative stress markers in the one-year prognosis of patients with acute ischemic stroke: a case-control study

Stroke is a major cause of mortality and morbidity. Also, free radicals and oxidative stress are deleterious factor in the stroke progression. We aimed to evaluate the association between oxidative stress mark...

Authors: Sheida Shaafi, Fina Hadisi, Mahsa Mahmoudinezhad, Hamidreza Razmi, Seyed Aria Nejadghaderi and Mohammad Khalili

Extreme ecchymoses in a migraine patient using concomitant treatment with calcitonin gene-related peptide receptor antibodies and fish oil supplements: a case report

Erenumab, a monoclonal antibody against the calcitonin gene-related peptide (CGRP) receptor, is registered for migraine prevention. Compared to other conventional migraine prevention medicines (i.e. topiramate...

Authors: C. K. Cullum, M. K. Olsen, H. B. Kocadag, M. Ashina and F. M. Amin

Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept study

Parkinson’s disease (PD) is a progressive neurodegenerative disease with no cure and few treatment options. Its incidence is increasing due to aging populations, longer disease duration and potentially as a CO...

Authors: Ann Liebert, Brian Bicknell, E-Liisa Laakso, Gillian Heller, Parastoo Jalilitabaei, Sharon Tilley, John Mitrofanis and Hosen Kiat

Increased cerebrospinal fluid adenosine 5'-triphosphate in patients with amyotrophic lateral sclerosis

Extracellular adenosine 5'-triphosphate (ATP) has been suggested to cause neuroinflammation and motor neuron degeneration by activating microglia and astrocytes in amyotrophic lateral sclerosis (ALS). Since we...

Authors: Takamasa Nukui, Atsushi Matsui, Hideki Niimi, Tomoyuki Sugimoto, Tomohiro Hayashi, Nobuhiro Dougu, Hirofumi Konishi, Mamoru Yamamoto, Ryoko Anada, Noriyuki Matsuda, Isao Kitajima and Yuji Nakatsuji

Determinants of participation and quality of life of young adults with cerebral palsy: longitudinal approach and comparison with the general population – SPARCLE 3 study protocol

Effective inclusion in society for young people with disabilities is increasingly seen as generating opportunities for self-development, and improving well-being. However, significant barriers remain in the va...

Authors: Catherine Arnaud, Carine Duffaut, Jérôme Fauconnier, Silke Schmidt, Kate Himmelmann, Marco Marcelli, Lindsay Pennington, Joaquim Alvarelhão, Chirine Cytera, Marion Rapp, Virginie Ehlinger and Ute Thyen

Comparisons of clinical characteristics, brain MRI findings, and responses to epidural blood patch between spontaneous intracranial hypotension and post-dural puncture headache: retrospective study

Spontaneous intracranial hypotension and post-dural puncture headache are both caused by a loss of cerebrospinal fluid but present with different pathogeneses. We compared these two conditions concerning their...

Authors: Gha-Hyun Lee, Jiyoung Kim, Hyun-Woo Kim and Jae Wook Cho

Autonomic dysreflexia associated with cervical spinal cord gliofibroma: case report

Autonomic dysreflexia (AD) is an abnormal reflex of the autonomic nervous system normally observed in patients with spinal cord injury from the sixth thoracic vertebra and above. AD causes various symptoms inc...

Authors: Hiroyuki Mizuno, Fumiaki Honda, Hayato Ikota and Yuhei Yoshimoto

Sociodemographic factors associated with the first administration of anti-seizure medication in patients with focal epilepsy in Western China

Epilepsy is a severe chronic neurologic disease with a prevalence of 0.7% worldwide; anti-seizure medications (ASMs) are the mainstay of epilepsy treatment. The effects of sociodemographic factors on the chara...

Authors: Qiong Zhu, Yi Guo, Shuai Ma, Lili Yang, Zhonghua Lin, Hongbin Sun, Guangzong Li and Liang Yu

Correction to: Cerebellar transcranial direct current stimulation in spinocerebellar ataxia type 3 (SCA3-tDCS): rationale and protocol of a randomized, double-blind, sham-controlled study

Authors: Roderick P. P. W. M. Maas, Ivan Toni, Jonne Doorduin, Thomas Klockgether, Dennis J. L. G. Schutter and Bart P. C. van de Warrenburg

Effects of combining manual therapy, neck muscle exercises, and therapeutic pain neuroscience education in patients with migraine: a study protocol for a randomized clinical trial

Non-pharmacological approaches for the management of migraine exhibit low to moderate effectiveness due to a lack of high-quality randomized clinical trials. In fact, previous studies applied isolated techniqu...

Authors: Gabriella de Almeida Tolentino, Lidiane Lima Florencio, Carina Ferreira Pinheiro, Fabíola Dach, César Fernández-de-las-Peñas and Débora Bevilaqua-Grossi