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Table 2 Epidemiological Data Used in the Model

From: The genetic basis of multiple sclerosis: a model for MS susceptibility

  Population Men Women
Prevalence of MS [P(MS)] * 150 71.4 228.6
MZ twin Concordance (CRMZ) * 25% 6.5% 34.0%
Raw% Susceptible [P(MS)]/CRMZ)* 0.6% 1.1% 0.7%
Corrected% Susceptible** 1.1% 2.0% 1.3%
% HLA DRB1*1501 (General Population) * 24%   
% HLA DRB1*1501 (MS Population) * 55%   
Homozygous DRB1*1501 (General Population) 1.6%   
Homozygous DRB1*1501 (MS Population) 10.0%   
  1. ‡ For estimated recurrence risks in 1st, 2nd, and 3rd degree relatives; see Table 12
  2. For estimated recurrence risk in HLA DRB1*1501 positive and negative patients; see Table 3.
  3. * From Canadian Data [11], based on prevalence of 150/100,000 population [16] and split into men and women according to [17]. HLA data: D Sadovnick (personal communication)
  4. ** Percent of the population genetically susceptible to susceptible to MS [P(MS)]/CRMZ] corrected (see text) for the reported [11] difference in concordance risk for DZ twins (5.4%) and non-twin siblings (2.9%)
  5. † UCSF Database: J Oksenberg (personal communication)