Skip to main content

Table 2 Epidemiological Data Used in the Model‡

From: The genetic basis of multiple sclerosis: a model for MS susceptibility

 

Population

Men

Women

Prevalence of MS [P(MS)] *

150

71.4

228.6

MZ twin Concordance (CRMZ) *

25%

6.5%

34.0%

Raw% Susceptible [P(MS)]/CRMZ)*

0.6%

1.1%

0.7%

Corrected% Susceptible**

1.1%

2.0%

1.3%

% HLA DRB1*1501 (General Population) *

24%

  

% HLA DRB1*1501 (MS Population) *

55%

  

Homozygous DRB1*1501 (General Population) †

1.6%

  

Homozygous DRB1*1501 (MS Population)†

10.0%

  
  1. ‡ For estimated recurrence risks in 1st, 2nd, and 3rd degree relatives; see Table 12
  2. For estimated recurrence risk in HLA DRB1*1501 positive and negative patients; see Table 3.
  3. * From Canadian Data [11], based on prevalence of 150/100,000 population [16] and split into men and women according to [17]. HLA data: D Sadovnick (personal communication)
  4. ** Percent of the population genetically susceptible to susceptible to MS [P(MS)]/CRMZ] corrected (see text) for the reported [11] difference in concordance risk for DZ twins (5.4%) and non-twin siblings (2.9%)
  5. † UCSF Database: J Oksenberg (personal communication)
Back to article page

BMC Neurology

ISSN: 1471-2377

Contact us