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Table 3 MS Concordance rates in Monozygotic Twins of HLA DRB1*1501-positive (ZH+) and HLA DRB1*1501-negative (ZH-) Probands *.

From: The genetic basis of multiple sclerosis: a model for MS susceptibility

  Monozygotic Twins of MS Probands  
  HLA DRB1*1501 Positive HLA DRB1*1501 Negative Totals
Concordant for MS (C) 9 11 20
Discordant for MS (D) 31 42 73
Totals 40 53 93
Pair-wise Concordance ZH+ = (9/40) = 23% ZH- = (11/53) = 21%  
Proband-wise Concordance †† ZH+ = 31% ZH- = 29%  
Proband-wise Concordance (Adjusted) ††† ZH+ = 17% ZH- = 16%  
  1. * Data derived from: Willer et al., 2003 [11]
  2. † Pair-wise rates calculated as (Z = C/(C + D).
  3. †† Proband-wise concordance rates calculated as (Z = 2C/(2C + D) adjusted [21] for the overall probability of doubly ascertaining concordant twin-pairs (54%) in the Willer, et al., 2003 [11] study.
  4. ††† See Text, Equation (20)