Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus

BMC Neurology

Table 3 DTI differences between NPSLE patients and controls

FA Controls > NPSLE
Voxels	p-value	Max-t	MNI X	MNI Y	MNI Z	Approximate white matter tract
266	0.001	3.135	30	17	18	Right superior longitudinal fasciculus
223	0.001	3.242	11	-34	25	Splenium of CC
172	0.003	3.408	-8	5	25	Body of CC
165	0.003	3.028	-26	28	12	Left anterior corona radiata
120	0.006	3.006	34	-41	28	Right superior longitudinal fasciculus
MD NPSLE > Controls
Voxels	p-value	Max-t	MNI X	MNI Y	MNI Z	Approximate white matter tract
454	< 0.001	3.201	-35	-28	30	Left superior longitudinal fasciculus
426	< 0.001	3.028	-24	15	19	Left anterior corona radiata
214	0.001	4.027	22	-19	37	Right superior corona radiata
193	0.001	3.195	30	0	28	Right superior longitudinal fasciculus
130	0.002	3.624	27	-42	33	Right superior longitudinal fasciculus
119	0.002	4.09	-2	-9	10	Left anterior thalamic radiation
103	0.003	3.738	-23	-56	21	Left arm of forceps major
100	0.003	3.074	-28	24	21	Left anterior thalamic radiation
97	0.003	4.055	29	20	18	Right inferior fronto-occipital fasciculus
88	0.004	3.867	25	-53	18	Splenium of CC
73	0.007	3.167	-8	-29	24	Body of CC
64	0.009	3.128	33	-17	26	Right superior longitudinal fasciculus

DTI differences between NPSLE patients and controls. Upper section lists significant regions in which controls had greater fractional anisotropy (FA) than NPSLE patients. Lower panel lists regions in which NPSLE patients had greater mean diffusivity (MD) than control subjects. Voxels = significant contiguous voxel cluster. Max-t = t statistic of voxel cluster difference between controls and NPSLE. MNI X, Y, Z = Montreal Neurological Institute coordinates of centroid location of significant voxel cluster. CC = corpus callosum.

ISSN: 1471-2377