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Table 1 PON1 genotype and allelic variants of patients with brain tumor (BT) and healthy volunteers.

From: Two common nonsynonymous paraoxonase 1 (PON1) gene polymorphisms and brain astrocytoma and meningioma

 

BT PATIENTS (N = 73, 146 chromosomes)

CONTROLS (N = 220, 440 chromosomes)

OR (95% CI); P

GENOTYPES

   

PON1 55 Leu/Leu

11 (15.1) [6.9-23.3]

38 (17.3) [12.3-22.3]

0.85 (0.41-1.75); 0.6621

PON1 55 Leu/Met

32 (43.8) [32.5-55.2]

94 (42.7) [36.2-49.3]

--

PON1 55 Met/Met

30 (41.1) [29.8-52.4]

88 (40.0) [33.5-46.5]

1.05 (0.61-1.79); 0.8692

PON1 192 Gln/Gln

31 (42.5) [31.1-53.8]

109 (49.5) [42.9-56.2]

0.75 (0.44-1.28); 0.2951

PON1 192 Gln/Arg

33 (45.2) [33.8-56.6]

89 (40.5) [34.0-46.9]

--

PON1 192 Arg/Arg

9 (12.3) [4.8-19.9]

22 (10.0) [6.0-14.0]

1.27 (0.57-2.85); 0.5762

ALLELES

   

PON1 55 Leu

54 (37.0) [29.2-44.8]

170 (38.6) [34.1-43.2]

0.93 (0.63-1.37); 0.7223

PON1 55 Met

92 (63.0) [55.2-70.8]

270 (61.4) [56.8-65.9]

--

PON1 192 Gln

95 (65.1) [57.3-72.8]

307 (69.8) [65.5-74.1]

--

PON1 192 Arg

51 (34.9) [27.2-42.7]

133 (30.2) [25.9-34.5]

1.24 (0.84-1.84); 0.2893

  1. The values in each cell represent: number (percentage) and [95% confidence intervals]. 1The OR was calculated by using the dominant model. 2The OR was calculated by using the recessive model. 3The OR was calculated by using the allelic model. Test for trend with the number of variant alleles: PON1 55 Leu/Met: H = 0.0957 df = 1 p = 0.7570; PON1 192 Gln/Arg: H = 1.1416 df = 1 p = 0.2853.