Two common nonsynonymous paraoxonase 1 (PON1) gene polymorphisms and brain astrocytoma and meningioma

BMC Neurology

Table 2 PON1 genotype and allelic variants of patients with different types of brain tumor.

	Astrocytoma (N = 44, 88 chromosomes)	OR (95% CI); P	Meningioma (N = 29, 58 chromosomes)	OR (95% CI); P
GENOTYPES
PON1 55 Leu/Leu	8 (18.2) [6.8-29.6]	1.07 (0.47-2.43); 0.885¹	3 (10.3) [0-21.4]	0.55 (0.17-1.81); 0.345¹
PON1 55 Leu/Met	19 (43.2) [28.5-57.8]	--	13 (44.8) [26.7-62.9]	--
PON1 55 Met/Met	17 (38.6) [24.2-53.0]	0.94 (0.49-1.82); 0.866²	13 (44.8) [26.7-62.9]	1.22 (0.57-2.62); 0.619²
PON1 192 Gln/Gln	19 (43.2) [28.5-57.8]	0.77 (0.41-1.48); 0.442¹	12 (41.4) [23.5-59.3]	0.72 (0.33-1.56); 0.409¹
PON1 192 Gln/Arg	20 (45.5) [30.7-60.2]	--	13 (44.8) [26.7-62.9]	--
PON1 192 Arg/Arg	5 (11.4) [2.0-20.7]	1.15 (0.43-3.14); 0.786²	4 (13.8) [1.2-26.3]	1.44 (0.48-4.34); 0.531²
ALLELES
PON1 55 Leu	35 (39.8) [29.5-50.0]	1.05 (0.66-1.67); 0.842³	19 (32.8) [20.7-44.8]	0.77 (0.44-1.38); 0.386³
PON1 55 Met	53 (60.2) [50.0-70.5]	--	39 (67.2) [55.2-79.3]	--
PON1 192 Gln	58 (65.9) [56.0-75.8]	--	37 (63.8) [51.4-76.2]	--
PON1 192 Arg	30 (34.1) [24.2-44.0]	1.19 (0.74-1.94); 0.474³	21 (36.2) [23.8-48.6]	1.31 (0.74-2.31); 0.355³

The values in each cell represent: number (percentage) and [95% confidence intervals]. ¹The OR was calculated by using the dominant model. ²The OR was calculated by using the recessive model. ³The OR was calculated by using the allelic model. Test for trend with the number of variant alleles: Astrocytoma PON1 55 Leu/Met: H = 0.0360 df = 1 p = 0.8496; PON1 192 Gln/Arg: H = 0.5537 df = 1 p = 0.4568. Meningioma PON1 55 Leu/Met: H = 0.5987 df = 1 p = 0.4391; PON1 192 Gln/Arg: H = 0.8057 df = 1 p = 0.3694.

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