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Table 2 Adverse Events During Minocycline Treatment Period

From: Open-label add-on treatment trial of minocycline in fragile X syndrome

Symptom

Time Period 1

Total Events2

Total Subjects3

Relationship to Minocycline Treatment

 

0-4

4+

  

Unrelated

Unlikely

Possible

Probable

Definite

Diarrhea

3

 

3

3

    

✔

Abdominal pain

1

1

2

2

✔

    

Nausea

1

 

1

1

  

✔

  

Fatigue

2

 

2

2

  

✔

  

Dizziness

2

3

5

4

   

✔

 

Sleepiness

 

2

2

2

   

✔

 

Headache

1

3

4

2

   

✔

 

Pruritus

 

2

2

2

  

✔

  

Arthralgia

 

2

2

2

✔

    

Epistaxis

1

 

1

1

✔

    

Odynophagia

  

1

1

✔

    

Dark urine

 

1

1

1

 

✔

   

Seizure

 

2

4

2

 

✔

   

Labs

         

   +ANA

 

2

2

2

    

✔

  1. 1 Time period in weeks such that 0-4 represents the first 4 weeks of treatment and 4+ represents the time between 4 weeks and 8 weeks.
  2. 2 Total events is the total number of events that occurred during the treatment period.
  3. 3 Total subjects is the total number of subjects experiencing the event (some subjects had an event more than once).
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BMC Neurology

ISSN: 1471-2377

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