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Table 2 Adverse Events During Minocycline Treatment Period

From: Open-label add-on treatment trial of minocycline in fragile X syndrome

Symptom Time Period 1 Total Events2 Total Subjects3 Relationship to Minocycline Treatment
  0-4 4+    Unrelated Unlikely Possible Probable Definite
Diarrhea 3   3 3      ✔
Abdominal pain 1 1 2 2 ✔     
Nausea 1   1 1    ✔   
Fatigue 2   2 2    ✔   
Dizziness 2 3 5 4     ✔  
Sleepiness   2 2 2     ✔  
Headache 1 3 4 2     ✔  
Pruritus   2 2 2    ✔   
Arthralgia   2 2 2 ✔     
Epistaxis 1   1 1 ✔     
Odynophagia    1 1 ✔     
Dark urine   1 1 1   ✔    
Seizure   2 4 2   ✔    
Labs          
   +ANA   2 2 2      ✔
  1. 1 Time period in weeks such that 0-4 represents the first 4 weeks of treatment and 4+ represents the time between 4 weeks and 8 weeks.
  2. 2 Total events is the total number of events that occurred during the treatment period.
  3. 3 Total subjects is the total number of subjects experiencing the event (some subjects had an event more than once).
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