Table 1 Demographic and clinical characteristics in multiple sclerosis patients and healthy controls.
| Â | MS (n = 59) | HC (n = 33) | p | RR (n = 41) | SP (n = 18) | p |
|---|---|---|---|---|---|---|
Female gender, n (%) | 43 (72.9) | 20 (60.6) | NS | 28 (68.2) | 15 (83.3) | NS |
Age in years, mean (SD) | 44.6 (11) | 41.3 (11.1) | NS | 40.5 (9.6) | 53.8 (8.1) | < .0001 |
Age at onset, mean (SD) | 30.9 (9.8) | ---- | --- | 30.6 (8.6) | 31.7 (12.3) | NS |
Disease duration, mean (SD) | 13.3 (10) | --- | --- | 9.5 (5.7) | 21.9 (12) | < .0001 |
Expanded Disability Status Scale, mean (SD) median | 3.2 (1) 2.5 | --- | --- | 2.1 (0.9) 2.0 | 5.9 (1.1) 6.0 | < .0001 |
T2 lesion volume, mean (SD) | 12.8 (15.2) | 2.3 (2.5) | < .0001 | 8.9 (7.7) | 21.9 (23) | .0014 |
T1 lesion volume, mean (SD) | 2.5 (6.5) | --- | --- | 1.3 (2.8) | 5.5 (10.6) | .016 |
Gadolinium lesion volume, mean (SD) | 0.07 (0.4) | --- | --- | 0.1 (0.5) | 0.01 (0.04) | NS |
Normalized brain volume, mean (SD) | 1545.1 (107.3) | 1642.4 (81.8) | < .0001 | 1575.2 (94.5) | 1476.4 (105.3) | .002 |
Normalized gray matter volume, mean (SD) | 828 (97.2) | 882.4 (112.8) | .022 | 855.8 (93.5) | 764.7 74.5) | < .0001 |
Normalized white matter volume, mean (SD) | 717.1 (68.5) | 725.6 (72.6) | .018 | 719.5 (73) | 711.7 (58.3) | NS |