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Table 2 Main statistical results and localization of peak voxels where cerebral metabolism was activated (>) or deactivated (<)

From: Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study

Analysis

Brain region

Talairach coordinates

Z score of peak

p FDR corrected

  

x

y

z

  

drCCH > HV

ACC

12

40

-4

5

< 0.001

 

Perigenual ACC

-8

28

-8

5.29

< 0.001

 

Midcingulate

12

20

30

4.07

0.003

 

Left visual cortex

-10

-98

-8

3.43

0.010

 

Left pulvinar

-16

-36

8

4.49

0.001

 

Left hypothalamus

-2

-12

-16

2.71

0.013

 

Cerebellum

-16

-36

46

4.28

0.002

 

Midbrain

2

-34

-4

3.53

0.008

 

Left lower pons

-8

-32

-46

4.13

0.003

drCCH < HV

R/L Sensorimotor

-58

-34

-18

4.43

0.012

  

58

-18

-26

4.42

0.012

  

-4

-22

70

4.26

0.012

  

-25

-22

66

3.73

0.015

  

-6

-24

68

3.37

0.025

 

Right prefrontal

42

26

24

3.76

0.015

Base > ONS

ACC

-8

28

-8

4.66

0.003

 

Midcingulate

12

20

30

3.75

0.013

 

Left visual cortex

-10

-98

-10

3.25

0.031

 

Left pulvinar

-18

-38

6

3.8

0.012

 

Cerebellum

2

-42

-16

3.67

0.015

 

Midbrain

2

-40

-12

3.63

0.016

 

Left lower pons

-8

-30

-44

4.40

0.024

Base < ONS

R/L Sensorimotor

-58

-34

-18

4.59

0.013

  

58

-18

-26

4.26

0.037

  

42

26

24

3.75

0.026

  

-4

-22

70

3.78

0.029

Resp > non resp

Perigenual ACC

-8

28

-8

4.01

0.002*

  1. Coordinates are in the standardized stereotactic Montreal Neurological Institute space (mm). FDR = False discovery rate corrected. drCCH: drug-resistant chronic cluster headache; HV: healthy volunteers; ACC: anterior cingulate cortex, R: right, L: left. * FDR corrected in region of interest identified in whole group analysis