Skip to main content

Table 2 Main statistical results and localization of peak voxels where cerebral metabolism was activated (>) or deactivated (<)

From: Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study

Analysis Brain region Talairach coordinates Z score of peak p FDR corrected
   x y z   
drCCH > HV ACC 12 40 -4 5 < 0.001
  Perigenual ACC -8 28 -8 5.29 < 0.001
  Midcingulate 12 20 30 4.07 0.003
  Left visual cortex -10 -98 -8 3.43 0.010
  Left pulvinar -16 -36 8 4.49 0.001
  Left hypothalamus -2 -12 -16 2.71 0.013
  Cerebellum -16 -36 46 4.28 0.002
  Midbrain 2 -34 -4 3.53 0.008
  Left lower pons -8 -32 -46 4.13 0.003
drCCH < HV R/L Sensorimotor -58 -34 -18 4.43 0.012
   58 -18 -26 4.42 0.012
   -4 -22 70 4.26 0.012
   -25 -22 66 3.73 0.015
   -6 -24 68 3.37 0.025
  Right prefrontal 42 26 24 3.76 0.015
Base > ONS ACC -8 28 -8 4.66 0.003
  Midcingulate 12 20 30 3.75 0.013
  Left visual cortex -10 -98 -10 3.25 0.031
  Left pulvinar -18 -38 6 3.8 0.012
  Cerebellum 2 -42 -16 3.67 0.015
  Midbrain 2 -40 -12 3.63 0.016
  Left lower pons -8 -30 -44 4.40 0.024
Base < ONS R/L Sensorimotor -58 -34 -18 4.59 0.013
   58 -18 -26 4.26 0.037
   42 26 24 3.75 0.026
   -4 -22 70 3.78 0.029
Resp > non resp Perigenual ACC -8 28 -8 4.01 0.002*
  1. Coordinates are in the standardized stereotactic Montreal Neurological Institute space (mm). FDR = False discovery rate corrected. drCCH: drug-resistant chronic cluster headache; HV: healthy volunteers; ACC: anterior cingulate cortex, R: right, L: left. * FDR corrected in region of interest identified in whole group analysis