Methylenetetrahydrofolate Reductase Gene Variant (MTHFR C677T) and Migraine: A Case Control Study and Meta-analysis

Table 1 Migraine and MTHFR case control studies

Migraine	Population	Cases	Controls	OR (95%CI)	Reference
MA	British Caucasian	124	1725	1.3 (1.01-1.70)	Current
MA	North Indian	67	150	1.295^"a" (0.676-2.478)	[44]
MA	Portuguese	78	397	0.48 (0.18-1.23)	[29]
MA	Italian	100	105	2.48 (1.11-5.58)	[39]
MA, MO	Italian	105 (90 MO and 15 MA)	97	MA: 2.16 (0.64-7.41) MO: 2.04 (0.98-4.22)	[45]
MA	Italian	33 (5-17 yr old)	66 (Adults)	2.18 (0.68, 7)	[46]
MA ^"b"	USA Caucasian female only	1275	23726	0.79 (0.65-0.96)	[26]
MA	Japanese	22	261	6.5 (2.5-16.8)	[12]
MA, MO	Turkish	93(23 MA; 70 MO)	136	MA: 3.05 (0.39-24.51) MO: 7.44 (1.70-32.34)	[11]
MA, MO	Spanish Caucasian	230 (78 MA and 152 MO)	204	MA: 1.37 (0.63-2.94) MO: 0.59 (0.27-1.24)	[15]
MA	Australian Caucasian	168	269	2.54 (1.37-4.71)	[13]
MA, MO	Spanish Caucasian	329 (138 MA and 191 MO)	237	MA: 2.4 (0.8-7.2) MO: 0.28 (0.1-0.8)	[37]
MA	Dutch	187	1212	2.05 (1.2-3.4)	[14]
MA	German	656	625	0.87 (0.61-1.25)	[16]
MA	Finnish	898	900	0.98 (0.84-1.15) ^"c"	[17]

MA migraine with aura, MO migraine without aura. OR for T/T genotype of MTHFR C677T polymorphism. ^"a" CT genotype is the reference point. MA n = 67, 0% TT genotype, 69.9% CC, 30.1% CT. healthy controls n= 150, TT 2%, CC 72% and CT 26%.
^"b" self reported migraine with aura. ^"c" OR for T allele frequency in cases and controls. 12.7% of cases did not fulfil criteria for MA based on the International Headache Society Criteria for MA. MA here is therefore used as a broad definition.

ISSN: 1471-2377