Table 1 Demographics at baseline and clinical variables at baseline and follow-up of the MS patients and the control group of the test cohort
From: Computational classifiers for predicting the short-term course of Multiple sclerosis
MS | HC | p value | |
|---|---|---|---|
N | 51 | 20 | -- |
Age | 35.1 (8.9) | 33.2 (9.1) | n.s. |
Sex (male/female) | 18/33 | 5/15 | n.s. |
Duration (years) | 5.9 (7.4) | -- | -- |
Disease subtype | CIS (16), RRMS (26), SPMS (3), PPMS (4), PRMS (2) | -- | -- |
Number of relapses in the previous 2 years | 1.29 (1.51) | -- | -- |
EDSS at baseline | 2.0 (0-6) | -- | -- |
MSSS at baseline | 4.6 | -- | -- |
MSFC at baseline | 0.08 (0.70) | -- | -- |
EDSS at follow-up | 2.0 (0-7) | -- | -- |
Change EDSS at follow-up | 0.35 (0.37) | -- | -- |
Disability progression at follow-up (yes/no) | 15/36 | -- | -- |
MSFC at follow-up | 0.19 (0.67) | -- | -- |
Relapse rate follow-up | 0.57 (0.50) | -- | -- |
Relapse-free patients follow-up | 21 | -- | -- |
DMD (yes/no) | 28/23 | -- | -- |
DMD type (Avonex/Betaferon/Rebif/Copaxone/Azatioprine/Mitoxantrone) | 3/8/9/0/1/1 | -- | -- |
Right ADM CMCT (ms) | 10.63 (3.88) | 8.09 (1.22) | 0.009 |
Left ADM CMCT (ms) | 10.71 (3.73) | 7.91 (1.25) | < 0.0001 |
Right FHB CMCT (ms) | 22.64 (10.57) | 14.74 (2.36) | < 0.0001 |
Left FHB CMCT (ms) | 20.52 (6.82) | 15.81 (3.14) | < 0.0001 |
T1 lesion volume (cm3) | 16.72 (20.23) | -- | -- |
T2 lesion volume (cm3) | 47.56 (42.77) | -- | -- |
Gad+ volume (cm3) | 0.29 (0.94) | -- | -- |
GM volume (cm3) | 522.50 (52.29) | -- | -- |
WM volume (cm3)* | 506.38 (59.40) | -- | -- |