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Table 3 Correlations of cognitive and MSFC measures with physical and mental MSQOL-54 and EDSS at screening (Day 0) and Month 24

From: Cognitive performance in relapsing remitting multiple sclerosis: A longitudinal study in daily practice using a brief computerized cognitive battery

  MSQOL-54 Physical MSQOL-54 Mental EDSS
  Day 0 Month 24 Day 0 Month 24 Day -60 Month 24
Power of Attention 0.14
p = 0.4371
0.21
p = 0.2707
0.1
p = 0.5311
0.07
p = 0.6964
0.62
p < 0.0001
0.5
p = 0.0023
Continuity of Attention 0.16
p = 0.2395
0.34
p = 0.0755
0.04
p = 0.8276
0.04
p = 0.8132
0.43
p = 0.0062
0.53
p = 0.001
Quality of working Memory 0.06
p = 0.733
0.35
p = 0.0598
0.14
p = 0.3742
0.41
p = 0.017
0.48
p = 0.0018
0.37
p = 0.0276
Quality of Episodic Memory 0.01
p = 0.9654
0.64
p = 0.0034
0.02
p = 0.9028
0.6
p = 0.0029
0.33
p = 0.0422
0.35
p = 0.0892
Speed of Memory 0.18
p = 0.3038
0.42
p = 0.0239
0.02
p = 0.8819
0.19
p = 0.2949
0.45
p = 0.0035
0.43
p = 0.0092
CDR composite 0.19
p = 0.2711
0.47
p = 0.0412
0.13
p = 0.4107
0.25
p = 0.2676
0.59
p < 0.0001
0.61
p = 0.0015
DSST 0.24
p = 0.1618
0.27
p = 0.2395
0.09
p = 0.5748
0.06
p = 0.7577
0.47
p = 0.0028
0.76
p < 0.0001
Timed 25-FWT 0.35
p = 0.0373
0.27
p = 0.154
0.15
p = 0.343
0.07
p = 0.6786
0.0
p = 0.9764
0.49
p = 0.002
9-HPT 0.0
p = 0.9896
0.08
p = 0.6629
0.23
p = 0.12
0.08
p = 0.652
0.55
p = 0.0001
0.53
p = 0.0003
PASAT 3" 0.03
p = 0.8805
0.16
p = 0.411
0.07
p = 0.6612
0.06
p = 0.7142
0.4
p = 0.0071
0.42
p = 0.0091
MSFC 0.17
p = 0.3352
0.19
p = 0.3328
0.02
p = 0.9241
0.12
p = 0.4834
0.43
p = 0.0044
0.56
p = 0.0003
  1. MSFC, Multiple Sclerosis Functional Composite; MSQOL-54, Multiple Sclerosis-54 Quality of Life; EDSS, Expanded Disability Status Scale; CDR, Cognitive Drug Research, DSST, Digit Symbol Substitution Test; Timed 25-FWT, Timed 25 Foot Walk Test; 9-HPT, 9 Hole Peg Test, PASAT 3", Paced Auditory Serial Addition Test 3 sec. Correcting for multiplicity p-values are statistically significant at p < 0.0008.