Costs (€) | Non-PGB (N = 157) | PGB monotherapy (N = 577) | PGB add-on (N = 575) | p between groups | ||||
---|---|---|---|---|---|---|---|---|
Baseline | Change | Baseline | Change | Baseline | Change | Baseline | Change§ | |
Pharmacological treatment | 66.8 (93.1) | +34.6 (80.3)* | 82.3 (106.9) | +160.7 (123.9)* | 96.8 (120.2) | +154.5 (133.0)* | 0.004 | <0.001 |
Non-pharmacological treatment | 258.8 (1211.6) | -191.1 (1,185.5) ╪ | 168.5 (525.9) | -121.9 (494.2)* | 290.9 (983.1) | -223.6 (948.8)* | 0.043 | 0.220 |
Medical visits and hospitalizations | 430.3 (702.8) | -177.0 (695.3) ┼ | 351.3 (572.6) | -203 (485.4)* | 497.5 (1,044.6) | -250.2 (879.8)* | 0.010 | 0.058 |
Complementary tests | 228.2 (257.0) | -104.3 (282.4)* | 231.5 (247.2) | -158.1 (250.4)* | 282.1 (254.9) | -173.4 (261.1)* | 0.001 | 0.001 |
Total direct costs | 984.1 (1,684.3) | -437.8 (1,582.6) ┼ | 833.6 (934.4) | -322.4 (812.9)* | 1,167.3 (1,666.4) | -492.7 (1,491.4)* | 0.001 | 0.019 |
Indirect costs (LWDE) | 1,412.5 (1,339.7) | -607.5 (1,141.1)* | 1,636.1 (1,382.9) | -990.5 (1,187.9)* | 1,942.2 (1,485.4) | -1,072.8 (1,211.7)* | <0.001 | 0.005 |
Total costs | 2,396.6 (2,308.0) | -1,045.3 (1,989.6) | 2,469.7 (1,856.8) | -1,312.9 (1,543.0)* | 3,109.5 (2,495.8) | -1,565.5 (2,004.1)* | <0.001 | 0.030 |