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Table 5 Overall and by components 12-weeks costs expressed in year 2006 Euros.

From: A Cost-Consequences analysis of the effect of Pregabalin in the treatment of peripheral Neuropathic Pain in routine medical practice in Primary Care settings

Costs (€)

Non-PGB

(N = 157)

PGB monotherapy

(N = 577)

PGB add-on

(N = 575)

p between groups

 

Baseline

Change

Baseline

Change

Baseline

Change

Baseline

Change§

Pharmacological treatment

66.8 (93.1)

+34.6 (80.3)*

82.3 (106.9)

+160.7 (123.9)*

96.8 (120.2)

+154.5 (133.0)*

0.004

<0.001

Non-pharmacological treatment

258.8 (1211.6)

-191.1 (1,185.5)

168.5 (525.9)

-121.9 (494.2)*

290.9 (983.1)

-223.6 (948.8)*

0.043

0.220

Medical visits and hospitalizations

430.3 (702.8)

-177.0 (695.3)

351.3 (572.6)

-203 (485.4)*

497.5 (1,044.6)

-250.2 (879.8)*

0.010

0.058

Complementary tests

228.2 (257.0)

-104.3 (282.4)*

231.5 (247.2)

-158.1 (250.4)*

282.1 (254.9)

-173.4 (261.1)*

0.001

0.001

Total direct costs

984.1 (1,684.3)

-437.8 (1,582.6)

833.6 (934.4)

-322.4 (812.9)*

1,167.3 (1,666.4)

-492.7 (1,491.4)*

0.001

0.019

Indirect costs (LWDE)

1,412.5 (1,339.7)

-607.5 (1,141.1)*

1,636.1 (1,382.9)

-990.5 (1,187.9)*

1,942.2 (1,485.4)

-1,072.8 (1,211.7)*

<0.001

0.005

Total costs

2,396.6 (2,308.0)

-1,045.3 (1,989.6)

2,469.7 (1,856.8)

-1,312.9 (1,543.0)*

3,109.5 (2,495.8)

-1,565.5 (2,004.1)*

<0.001

0.030

  1. Values expressed as means (Standard deviation). *p < 0.0001; p < 0.001; p < 0.05 vs. intragroup baseline values; LWDE = Lost-workdays equivalents. §Between groups changes comparison adjusted by baseline values and number of previous drugs.