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Figure 3 | BMC Neurology

Figure 3

From: Intrathecal lidocaine pretreatment attenuates immediate neuropathic pain by modulating Nav1.3expression and decreasing spinal microglial activation

Figure 3

Intrathecal lidocaine pretreatment suppressed microglia-specific immunoreactivity induced by SNL in the spinal cord. Group S showed weak immunoreactivity of the microglial marker OX-42 in the left dorsal horn (A). In Group L, SNL induced a significant increase in microglia immunoreactivity in the ipsilateral spinal cord on POD3 (B) and POD7 (D). Intrathecal lidocaine pretreatment (Group P) decreased microglia immunoreactivity on POD3 (C) but not on POD7 (E). Data represent means ± SE (*p < 0.05, **p < 0.01, NS: not statistically significant; Mann-Whitney U test). Scale bars, 200 μm.

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BMC Neurology

ISSN: 1471-2377

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