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Figure 4 | BMC Neurology

Figure 4

From: Intrathecal lidocaine pretreatment attenuates immediate neuropathic pain by modulating Nav1.3expression and decreasing spinal microglial activation

Figure 4

Intrathecal lidocaine pretreatment moderated the increase in p-p38 immunoreactivity induced by SNL. Group S exhibited weak p-p38 immunoreactivity in the left dorsal horn (A). In Group L, p-p38 immunoreactivity was significantly increased in the left dorsal horn on POD3 (B) and on POD7 (D). Intrathecal lidocaine pretreatment (Group P) decreased SNL-induced p-p38 immunoreactivity on POD3 (C) and POD7 (E). Quantification of p-p38 immunoreactivity revealed significant increases on POD3 and POD7 after SNL. Intrathecal lidocaine pretreatment reduced p-p38 immunoreactivity after SNL (F). Merged images from OX-42 (green) and p-p38 (red) in the ipsilateral L5 spinal cord on POD3 showed p-p38 colocalization with OX-42 (G). Data represent means ± SE (*p < 0.05, **p < 0.01; Mann Whitney U test). Scale bars, 200 μm (A-E) and 50 μm (G).

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BMC Neurology

ISSN: 1471-2377

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