Table 1 Comparison between prodromal AD and stable MCI according to baseline clinical and neuropsychological features
Pr-AD n = 50 | S-MCI n = 55 | p-value | Pr-AD n = 50 | S-MCI n = 55 | p-value | ||
|---|---|---|---|---|---|---|---|
Age | 75.94 (6.05) | 72.93 (7.30) | 0.021 | MMSE | 25.92 (1.88) | 27.78 (1.55) | < 0.001 |
Sex (% female) | 59.37 | 64.58 | 0.575 | WAT | 16.87 (6.61) | 17.32 (7.96) | 0.778 |
Hamilton | 3.92 (3.36) | 6.32 (5.98) | 0.033 | Symbol-Digit | 23.21 (10.86) | 27.02 (10.86) | 0.142 |
IDDD | 41.09 (7.48) | 38.11 (4.62) | 0.071 | CVLT-SDFR | 1.52 (2.00) | 4.55 (3.90) | < 0.001 |
Hachinski | 1.97 (1.15) | 2.27 (1.72) | 0.373 | CVLT-SDTR | 3.78 (2.40) | 6.45 (3.32) | < 0.001 |
Social extraction (% urban) | 74.35 | 69.38 | 0.712 | CVLT-LDFR | 1.38 (1.86) | 4.83 (4.03) | < 0.001 |
Marital status (% married) | 56.41 | 71.42 | 0.143 | CVLT-LDTR | 3.29 (2.42) | 6.58 (3.42) | < 0.001 |
Education (% primary school) | 66.66 | 71.42 | 0.775 | CVLT- Learning | 12.83 (2.89) | 13.77 (2.17) | 0.054 |
HBP (%) | 45.83 | 32.81 | 0.161 | BNT | 8.13 (2.58) | 8.42 (2.46) | 0.544 |
DM (%) | 16.66 | 23.43 | 0.380 | Rey figure copy | 25.39 (10.71) | 26.97 (9.00) | 0.398 |
Smoking (% active) | 6.25 | 25.00 | 0.009 | WAIS block design | 17.90 (8.24) | 20.63 (7.89) | 0.112 |
Alcohol (% active) | 8.33 | 12.5 | 0.480 | Stroop Test (interference) | -7.36 (8.32) | -5.71 (6.24) | 0.233 |
Hypercholesterolemia (%) | 33.33 | 31.25 | 0.815 | TMT-A | 111.05 (79.87) | 88.38 (46.45) | 0.083 |
Statins (%) | 16.66 | 15.62 | 0.882 | TMT-B | 237.06 (120.56) | 196.20 (98.85) | 0.098 |
Ischemic cardiopathy (%) | 4.16 | 10.93 | 0.192 | Category fluency | 10.88 (4.33) | 12.87 (3.98) | 0.017 |
Previous Stroke (%) | 0 | 9.37 | 0.029 | Phonemic fluency | 5.89 (3.10) | 6.98 (3.54) | 0.099 |
Arterial ischemia (%) | 0 | 1.56 | 0.384 | FAB | 12.94 (2.15) | 14.44 (2.45) | 0.004 |
Family History of Dementia (%) | 31.25 | 28.12 | 0.720 | ||||
ApoE E4 carrier (%) | 53.48 | 28.30 | 0.012 |