| |
Pr-AD n = 50
|
S-MCI n = 55
|
p-value
| |
Pr-AD n = 50
|
S-MCI n = 55
|
p-value
|
|---|
|
Age
|
75.94 (6.05)
|
72.93 (7.30)
|
0.021
|
MMSE
|
25.92 (1.88)
|
27.78 (1.55)
|
< 0.001
|
|
Sex (% female)
|
59.37
|
64.58
|
0.575
|
WAT
|
16.87 (6.61)
|
17.32 (7.96)
|
0.778
|
|
Hamilton
|
3.92 (3.36)
|
6.32 (5.98)
|
0.033
|
Symbol-Digit
|
23.21 (10.86)
|
27.02 (10.86)
|
0.142
|
|
IDDD
|
41.09 (7.48)
|
38.11 (4.62)
|
0.071
|
CVLT-SDFR
|
1.52 (2.00)
|
4.55 (3.90)
|
< 0.001
|
|
Hachinski
|
1.97 (1.15)
|
2.27 (1.72)
|
0.373
|
CVLT-SDTR
|
3.78 (2.40)
|
6.45 (3.32)
|
< 0.001
|
|
Social extraction (% urban)
|
74.35
|
69.38
|
0.712
|
CVLT-LDFR
|
1.38 (1.86)
|
4.83 (4.03)
|
< 0.001
|
|
Marital status (% married)
|
56.41
|
71.42
|
0.143
|
CVLT-LDTR
|
3.29 (2.42)
|
6.58 (3.42)
|
< 0.001
|
|
Education (% primary school)
|
66.66
|
71.42
|
0.775
|
CVLT- Learning
|
12.83 (2.89)
|
13.77 (2.17)
|
0.054
|
|
HBP (%)
|
45.83
|
32.81
|
0.161
|
BNT
|
8.13 (2.58)
|
8.42 (2.46)
|
0.544
|
|
DM (%)
|
16.66
|
23.43
|
0.380
|
Rey figure copy
|
25.39 (10.71)
|
26.97 (9.00)
|
0.398
|
|
Smoking (% active)
|
6.25
|
25.00
|
0.009
|
WAIS block design
|
17.90 (8.24)
|
20.63 (7.89)
|
0.112
|
|
Alcohol (% active)
|
8.33
|
12.5
|
0.480
|
Stroop Test (interference)
|
-7.36 (8.32)
|
-5.71 (6.24)
|
0.233
|
|
Hypercholesterolemia (%)
|
33.33
|
31.25
|
0.815
|
TMT-A
|
111.05 (79.87)
|
88.38 (46.45)
|
0.083
|
|
Statins (%)
|
16.66
|
15.62
|
0.882
|
TMT-B
|
237.06 (120.56)
|
196.20 (98.85)
|
0.098
|
|
Ischemic cardiopathy (%)
|
4.16
|
10.93
|
0.192
|
Category fluency
|
10.88 (4.33)
|
12.87 (3.98)
|
0.017
|
|
Previous Stroke (%)
|
0
|
9.37
|
0.029
|
Phonemic fluency
|
5.89 (3.10)
|
6.98 (3.54)
|
0.099
|
|
Arterial ischemia (%)
|
0
|
1.56
|
0.384
|
FAB
|
12.94 (2.15)
|
14.44 (2.45)
|
0.004
|
|
Family History of Dementia (%)
|
31.25
|
28.12
|
0.720
| | | | |
|
ApoE E4 carrier (%)
|
53.48
|
28.30
|
0.012
| | | | |
- Values are means (SD); p-value from univariate analysis, and in bold, those p-values which remained significant after the multivariate analysis adjusting for all associated variables plus age, sex and ApoeE e4 status; Pr-AD (prodromal AD): MCI patients that progressed to AD during the follow-up; S-MCI (stable MCI): MCI patients that did not progress to dementia; IDDD: Interview for Deterioration in Daily living activities in Dementia; HBP: High Blood Pressure; DM: Diabetes Mellitus; WAT: Word Accentuation Test; CVLT: California Verbal Learning Test; SDFR: Short Delayed Free Recall; SDTR: Short Delayed Total Recall (free and cued); LDFR: Long Delayed Free Recall; LDTR: Long Delayed Total Recall (free and cued); BNT: Boston Naming Test; TMT-A: Trail Making Test part A; TMT-B: Trail Making Test part B; FAB: Frontal Assessment Battery.
