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Table 1 Comparison between prodromal AD and stable MCI according to baseline clinical and neuropsychological features

From: Detection of early Alzheimer's disease in MCI patients by the combination of MMSE and an episodic memory test

  Pr-AD n = 50 S-MCI n = 55 p-value   Pr-AD n = 50 S-MCI n = 55 p-value
Age 75.94 (6.05) 72.93 (7.30) 0.021 MMSE 25.92 (1.88) 27.78 (1.55) < 0.001
Sex (% female) 59.37 64.58 0.575 WAT 16.87 (6.61) 17.32 (7.96) 0.778
Hamilton 3.92 (3.36) 6.32 (5.98) 0.033 Symbol-Digit 23.21 (10.86) 27.02 (10.86) 0.142
IDDD 41.09 (7.48) 38.11 (4.62) 0.071 CVLT-SDFR 1.52 (2.00) 4.55 (3.90) < 0.001
Hachinski 1.97 (1.15) 2.27 (1.72) 0.373 CVLT-SDTR 3.78 (2.40) 6.45 (3.32) < 0.001
Social extraction (% urban) 74.35 69.38 0.712 CVLT-LDFR 1.38 (1.86) 4.83 (4.03) < 0.001
Marital status (% married) 56.41 71.42 0.143 CVLT-LDTR 3.29 (2.42) 6.58 (3.42) < 0.001
Education (% primary school) 66.66 71.42 0.775 CVLT- Learning 12.83 (2.89) 13.77 (2.17) 0.054
HBP (%) 45.83 32.81 0.161 BNT 8.13 (2.58) 8.42 (2.46) 0.544
DM (%) 16.66 23.43 0.380 Rey figure copy 25.39 (10.71) 26.97 (9.00) 0.398
Smoking (% active) 6.25 25.00 0.009 WAIS block design 17.90 (8.24) 20.63 (7.89) 0.112
Alcohol (% active) 8.33 12.5 0.480 Stroop Test (interference) -7.36 (8.32) -5.71 (6.24) 0.233
Hypercholesterolemia (%) 33.33 31.25 0.815 TMT-A 111.05 (79.87) 88.38 (46.45) 0.083
Statins (%) 16.66 15.62 0.882 TMT-B 237.06 (120.56) 196.20 (98.85) 0.098
Ischemic cardiopathy (%) 4.16 10.93 0.192 Category fluency 10.88 (4.33) 12.87 (3.98) 0.017
Previous Stroke (%) 0 9.37 0.029 Phonemic fluency 5.89 (3.10) 6.98 (3.54) 0.099
Arterial ischemia (%) 0 1.56 0.384 FAB 12.94 (2.15) 14.44 (2.45) 0.004
Family History of Dementia (%) 31.25 28.12 0.720     
ApoE E4 carrier (%) 53.48 28.30 0.012     
  1. Values are means (SD); p-value from univariate analysis, and in bold, those p-values which remained significant after the multivariate analysis adjusting for all associated variables plus age, sex and ApoeE e4 status; Pr-AD (prodromal AD): MCI patients that progressed to AD during the follow-up; S-MCI (stable MCI): MCI patients that did not progress to dementia; IDDD: Interview for Deterioration in Daily living activities in Dementia; HBP: High Blood Pressure; DM: Diabetes Mellitus; WAT: Word Accentuation Test; CVLT: California Verbal Learning Test; SDFR: Short Delayed Free Recall; SDTR: Short Delayed Total Recall (free and cued); LDFR: Long Delayed Free Recall; LDTR: Long Delayed Total Recall (free and cued); BNT: Boston Naming Test; TMT-A: Trail Making Test part A; TMT-B: Trail Making Test part B; FAB: Frontal Assessment Battery.