Enhanced catecholamine transporter binding in the locus coeruleus of patients with early Parkinson disease

BMC Neurology

Table 2 Binding values obtained with the analysis of volumes of interest

Region of interest	PD	HC	p values
CN contralateral	3.18 (1.2 - 3.84)	5.27 (3.51 - 6.15)	< 0.0001
CN ipsilateral	3.29 (0.98 - 6.26)	5.27 (3.51 - 6.6)	< 0.0001
PT contralateral	1.86 (0.65 - 4.72)	4.83 (3.07 - 6.04)	< 0.0001
PT ipsilateral	1.97 (0.76 - 4.65)	4.83 (3.62 - 6.37)	< 0.0001
LC contralateral	313.5 (81 - 663)	131.43 (59 - 371)	0.001
LC ipsilateral	321.17 (87 - 632)	123.6 (38 - 354)	0.0004

Data are reported as median and range (brackets). Average FP-CIT binding in the caudate nucleus (CN) and putamen (PT) was significantly reduced in subjects with PD subjects compared to HC. On the contrary, PD patients showed a significantly increased binding in the LC area (both right and left regions). We defined contralateral brain regions opposite to that of PD signs presentation. For HC, we referred to the right side as ipsilateral [15].

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