From: Clinical correlates of grey matter pathology in multiple sclerosis
Study | Patients | Follow-up (years) | MRI measures | Main outcomes |
---|---|---|---|---|
Dalton et al., 2004 [11] | 58 CIS | 3 | GMF | Decrease in GMF was higher in patients who converted to CDMS (-3.3%) than in those who did not (-1.1%). |
Fisher et al., 2008 [12] | 7 CIS 36 RRMS 27 SPMS 17 HC | 4 | BPF, GMF, WMF | GMF decrease was more pronounced in patients compared to HC: CIS converting to RRMS, 3.4×; RRMS, 8.1×; RRMS converting to SPMS, 12.4×; SPMS, 14×. WMF decrease was 3× higher in all patient sub-groups than in HC. |
Fisniku et al., 2008 [36] | 29 CIS 33 RRMS 11 SPMS 25 HC | 20/cross-sectional | GMF, GMV WMF | GMF but not WMF correlated with EDSS (r = 0.48) and MSFC sub-scores (r = 0.59). |
Horakova et al., 2009 [102] | 170 RRMS | 5 | GMV, PBVC | Decline in PBVC and GMV were the strongest MRI predictors of disability progression. |
Calabrese et al., 2009 [30] | 48 PPMS | 2 | GMF, cortical lesions (volume, count) | Baseline volume of cortical lesions correlated with EDSS (r = 0.48) and its change over 2 years (r = 0.38). |
Calabrese et al., 2011 [96] | 105 CIS 42 HC | 4 | Regional atrophy | Atrophy of the superior frontal gyrus, thalamus, and cerebellum predicted independently conversion from CIS to CDMS. |
Roosendaal et al., 2011 [55] | 95 CIS 657 RRMS 125 SPMS 50 PPMS | cross-sectional | GMV | GMV was lower in SPMS than RRMS, and was the strongest independent predictor of physical disability and cognitive impairment. |
Amato et al., 2004 [40] | 41 RRMS 16 HC | cross-sectional | GMV | Cortical atrophy was found in cognitively impaired but not in cognitively preserved patients, and was correlated with a poorer performance on tests of verbal memory, attention, and verbal fluency. |
Amato et al., 2007 [101] | 28 RR MS | 2.5 | GMV, NCV PBVC | Decrease in cortical volume was significantly higher in cognitively deteriorating than in stable or improving patients (-43 ml vs. -18 ml). |
Tekok-Kilic et al., 2007 [68] | 59 CDMS | cross-sectional | GMF | Frontal atrophy was associated with impaired memory (auditory/verbal, visual episodic and working). |
Houtchens et al., 2007 [161] | 62 RR MS 16 SP MS 1 PP MS 16 HC | cross-sectional | thalamic volume | Thalamic volume was 17% lower in the MS group than in HC, and was associated with impaired cognitive performance (r = 0.51-0.72) and physical disability (r = 0.32). |
Calabrese et al., 2009 [37] | 70 RR MS | cross-sectional | cortical lesions NCV | Higher number and volume of cortical lesions and lower volume of neocortical grey matter were seen in cognitively impaired vs. cognitively preserved patients. |