Figure 6
Mean-standard deviation plot of the calculated EC 50 values (mean ± SD) at either α1-(WT) or mutations -R271Q, -R271L, -R271K and -S267I expressed in HEK293 cells following application of 4-chloropropofol. P-values of Mann–Whitney U test result in significant differences between EC50 of WT and the corresponding GlyR-mutation, indicated as significance levels of *p<0.05 and **p<0.01 (WT vs. R271Q, p=0.0159; WT vs. R271L as well as vs. R271K, p = 0.0095 and WT vs. S267I, p = 0.0286; n = 4–6 per group).