Table 1 Characteristics of the patients included in the post-hoc analysis
From: Transdermal rotigotine for the perioperative management of restless legs syndrome
Patient | Sex | Agea (years) | Surgical intervention | Concomitant medication prior to surgery | Surgery related concomitant medication | Rotigotine dose at time of surgery (mg/24 h) | Rotigotine dose following surgery (mg/24 h) | Outcome of surgery |
|---|---|---|---|---|---|---|---|---|
10306 | Female | 60 | Bypass and tricuspidal reconstruction | Acetylsalicylic acid 100 mg/day, fluvastatin 80 mg/day, pantoprazole sodium 40 mg/day, telmisartan 1 mg/day. | No concomitant medications recorded | 4 | 4 | recovered/resolved |
10311 | Female | 30 | Abortion | No concomitant medications recorded | No concomitant medications recorded | 2 | Discontinued 17 days prior to surgery | recovered/resolved |
10402 | Female | 54 | Right knee replacement | Zopiclone 3.75 mg/as needed | Ibuprofen 1800 mg/day after surgery | 4 | 4 | recovered/resolved with sequelae |
10404 | Female | 63 | Surgery for dislocated fracture of left distal radius | Levothyroxine 100 μg/day | Furosemide 20 mg/day, acemetacin 60 mg- 180 mg/day, paracetamol 4 g/day | 2 | 2 | recovered/resolved |
10429 | Female | 58 | Right hip replacement | Estradiol valerate twice weekly (unknown dose), levothyroxine sodium 50 mg/day, siccaprotect 3 drops/day (unknown dose) | Indometacin 75 mg/day | 3 | 3 | not recovered/resolved (osteoarthritis was considered to be ongoing) |
10702 | Male | 64 | Cardiac bypass surgery Right shoulder surgery (osteoarthritis) Angioplasty (internal carotid artery) | Cardiac bypass surgery: fenofibrate 160 mg/day, serenoa repens extract 320 mg/day, Sidros 80.5 mg/day, tamsulosin 0.4 mg/day Right shoulder surgery: heparin-fraction, sodium salt (dose unknown), torasemide 10 mg/day, bisoprolol 5 mg/day, simvastatin 40 mg/day Angioplasty: no additional medication | Cardiac bypass surgery: acetylsalicylic acid 100 mg/day, torasemide 10 mg/day, bisoprolol 5 mg/day, simvastatin 40 mg/day Right shoulder surgery: Ultracet (1tab/as needed), esomeprazole 20 mg/day, diclofenac 100 mg/day Angioplasty: no additional medication | 2 | 2 | Cardiac bypass surgery: recovered/resolved Right shoulder surgery: recovered/resolved Angioplasty: recovered/resolved |
10708 | Female | 62 | Hip replacement | Diclofenac 150 mg/day, estradiol valerate 1 mg/day | No concomitant medications recorded | 3 | 3 | recovered/resolved |
10713 | Female | 70 | Thyroid surgery Hip replacement | Thyroid surgery: simvastatin 40 mg/day, carbamazepine 400 mg/day Hip replacement: simvastatin 40 mg/day. levothyroxine 75 mg/day | Thyroid surgery: no concomitant medications recorded Hip replacement: no concomitant medications recorded | 4 | 4 | Thyroid surgery: recovered/resolved Hip replacement: recovered/resolved |
10801 | Female | 49 | Surgery for left lower leg fracture | Calcium with vitamin D (dose unknown), risedronate sodium 35 mg/weekly, omeprazole 40 mg/day. | No concomitant medications recorded | 3 | 3 (trial medication was temporarily suspended for the surgery and later resumed) | recovered/resolved |
10806 | Female | 43 | Hysterectomy | Timolol 1drop/day, domperidone 20 mg/day, acetylcysteine 600 mg/day | No concomitant medications recorded | 4 | 4 | recovered/resolved |
10906 | Female | 70 | Right knee replacement | Lisinopril 5 mg/day, acetylsalicylic acid 100 mg/day, trospium chloride 5 mg/day, ibuprofen 600 mg/every other day. | No concomitant medications recorded | 4 | 4 | resolved with sequelae |
10907 | Female | 68 | Hallux valgus surgery | Propranolol 50 mg/day, bisoprolol 50 mg/day, estriol 0.5 mg/biweekly | Heparin (dose unknown), ibuprofen 1800 mg/day | 4 | 4 | recovered/resolved with sequelae |
10908 | Female | 44 | Arthroscopy of right knee | No concomitant medication reported | Ibuprofen 600 mg/day | 2 | 2 | not recovered/not resolved |
10914 | Female | 71 | Right knee replacement Left knee replacement | Right knee replacement: bisoprolol 142.5 mg/day, ramipril 1.25 mg/day Left knee replacement: bisoprolol 142.5 mg/day, ramipril 1.25 mg/day | Right knee replacement: no concomitant medications recorded Left knee replacement: omeprazole 20 mg/day, enoxaparin 40 mg/day, tilidine hydrochloride 200 mg/day, indometacin 75 mg/day, metamizole 20 drops/as needed, gabapentin 900 mg/day | 4 | 4 | Right knee replacement: resolved with sequelae Left knee replacement: recovered/resolved with sequelae |
10915 | Female | 53 | Cholecystectomy | Opipramol 150 mg/day, pantoprazole sodium 20 mg/day | No concomitant medications recorded | 0.5 | 0.5 | recovered/resolved |
11108 | Female | 49 | Left shoulder surgery (impingement syndrome) | Estradiol valerat/norgestrel (administered in monthly cycle; 21 doses over 28 days) | No concomitant medications recorded | 4 | 4 | recovered/resolved |
11110 | Female | 70 | Hysterectomy | Theophylline 400 mg/day, ibuprofen 400 mg/day, fluticasone propionate/salmeterol xinafoate (dose unknown), cromoglicate sodium/reproterol hydrochloride (dose unknown), allopurinol 300 mg/day | No concomitant medications recorded | 2 | 2 | recovered/resolved |
11112 | Female | 23 | Submandibular cyst resection | No concomitant medications recorded | No concomitant medications recorded | 2 | 2 | recovered/resolved |
11209 | Male | 47 | Perianal abscess resection | Diltiazem 90 mg/day, pentaerithrityl tetranitrate 80 mg/day | Ibuprofen 1600 mg/day (discontinued because of an allergic reaction) thereafter tramadol 60 drops/day | 3 | 3 | recovered/resolved |
11211 | Male | 62 | Left knee replacement | Candesartan cilexetil (dose unknown)/day, celecoxib 100 mg/day, doxazosin mesilate (dose unknown)/day, dyazide 1tab/day, etoricoxib 60 mg/day, ibuprofen 600 mg/day, metoprolol succinate 95 mg/day, rofecoxib (dose unknown)/day | Heparin-fraction/sodium salt 2 mL /day, metamizole sodium 2000 mg/mL/day, tramadol hydrochloride 200 mg/day | 4 | 4 (after surgery), discontinued 23 days after surgery owing to rehabilitation | recovered/resolved |
11405 | Female | 64 | Surgery for lumbar spinal cord stenosis Left shoulder surgery (frozen shoulder) | Surgery for lumbar spinal cord stenosis: no concomitant medications recorded Left shoulder surgery: cefuroxime 1000 mg/day. | Surgery for lumbar spinal cord stenosis: no concomitant medications recorded Left shoulder surgery: no concomitant medications recorded | 4 | 4 | Surgery for lumbar spinal cord stenosis: recovered/resolved Left shoulder surgery: recovered/resolved |
11408 | Female | 63 | Vein stripping (both legs) | Olmesartan medoxomil 20 mg/day | Initially alfetanil, mepivacaine, midazolam, propofol (doses unknown). Thereafter ibuprofen (dose unknown) | 3 | 3 | recovered/resolved |
11419 | Male | 45 | Right shoulder surgery | No concomitant medications recorded | Ibuprofen 400 mg/as needed | 4 | 4 | recovered/resolved |
11428 | Female | 76 | Right thumb surgery (arthrosis metacarpophalangeal) | Cyanocobalamin 1 mL/month, pantoprazole sodium 40 mg/day | No concomitant medications recorded | 4 | 4 | recovered/resolved |
11430 | Female | 60 | Hallux valgus surgery | No concomitant medications recorded | Diclofenac 50 mg/as needed | 2 | 2 | recovered/resolved |
11501 | Male | 74 | Hip replacement | Alprostadi cream 10 μg/day, candesartan cilexetil 4 mg/day, itraconazole solution (dose unknown)/day, nifedipine 10 mg/day | No concomitant medications recorded | 4 | 4 | recovered/resolved |
11503 | Female | 63 | Tendon repair (supraspinatus) | Captopril 17.5 mg/day, levothyroxine sodium 50 μg/day, simvastatin 20 mg/day plus unspecified pain medication | No concomitant medications recorded | 4 | 4 | recovered/resolved with sequelae |
11601 | Female | 67 | Right knee replacement | Acetylsalicylic acid 300 mg/day, bisoprolol (dose unknown), conjugated estrogens (dose unknown) | Ibuprofen 800 mg/as needed, cortisone (dose unknown)/as needed | 4 | 4 | recovered/resolved |
11608 | Male | 76 | Surgery for salivary gland adenoma | Enalapril maleate 10 mg/day, amiloride hydrochlorothiazide 5 mg/day, ramipril 5 mg/day | No concomitant medications recorded | 4 | 4 | recovered/resolved with sequelae |
11609 | Male | 66 | Coronary artery disease, stent implant | No concomitant medications recorded | Acetylsalicylic acid 100 mg/day and blood coagulation factors 75 mg/day for 5 ½ months, thereafter asasantin 1 capsule/day; bisoprolol 5 mg/day | 4 | 4 | recovered/resolved |
11612 | Male | 71 | Surgical treatment of lipoma | No information available | No information available | Discontinued in order to plan for surgical treatment of the lipoma | Discontinued | ongoing |
11811 | Male | 64 | Hand surgery (Dupuytren’s contracture) | Dermatologicals 1 mg/day cream, enalapril maleate 0.5 mg/day, hydrochlorothiazide and 0.5 mg/day heparin-fraction/sodium salt 2500 IU/day (day prior to surgery) | Heparin-fraction/sodium salt 2500 IU/day, ibuprofen 600 mg/as needed | 3 | 3 | recovered/resolved |
11814 | Male | 43 | Laparoscopic surgery (inguinal hernia) | Ibuprofen 800 mg as needed, levothyroxine sodium/potassium iodide 75 μg/day | No concomitant medications recorded | 4 | 4 | recovered/resolved |
11901 | Female | 71 | Surgical elevation of bladder Radius fracture surgery | Surgical elevation of bladder: ginkgo biloba extract 80 mg/day, acetylsalicylic acid 100 mg/day, calcium compounds 1500 mg/day, bisoprolol 5 mg/day, estrogen 0.6 mg/day, omeprazole 20 mg/day, diclofenac 75 mg/prn, hypericum perforatum 1350 mg/day, losartan 50 mg/day Radius fracture surgery: acetylsalicylic acid 100 mg/day, bisoprolol 10 mg/day, bromazepam 6 mg/as needed, calcium compounds 1500 mg/day, diclofenac 75 mg/as needed, dimethindene drops 4.5 mg/day, estrogen 0.6 mg/day, furosemide 40 mg/day, ginkgo biloba extract 80 mg/day, hypericum perforatum 1350 mg/day, losartan 50 mg/day, omeprazole 20 mg/day, prednicarbate cream (dose unknown). Prior to surgery: metamizole 1000 mg/day, tilidine 100 mg/day, enoxaparin sodium 0.4 mL/day (prophylaxis of thrombosis), cefuroxime 1.5 mg/day (inflammatory prevention), bupivacaine 10 mL, mepivacaine 40 mL (anaesthesia), clorazepate dipotassium 10 mg (tranquilizer) midazolam 6 mg (sedative) | Surgical elevation of bladder: enoxaparin 40 mg/day, magnesium 1500 mg/day, ethinyl estradiol 20 mg/day, promethazine 25 mg/day, midazolam 3.75 mg/day, sultamicillin 1125 mg/day. Radius fracture surgery: tilidine 100 mg/day | 0.5 | 0.5 | Surgical elevation of bladder: recovered/resolved Radius fracture surgery: recovered/resolved |
11902 | Female | 66 | Surgical elevation of bladder | Esomeprazole 20 mg/day, pantoprazole 20 mg/day, methotrexate 25 mg/week, prednisolone 5 mg/day, metoprolol 25 mg/day, calcium folinate 6.35 mg/week, leflunomide 20 mg/day, nitrofurantoin 50 mg/day, vitamin C + calcium (dose unknown) | Sulfamethoxazole (dose unknown) | 4 | 4 | recovered/resolved |
12102 | Female | 59 | Repair of incisional hernia | Diclofenac 75 mg/as needed, ibuprofen (unknown dose)/as needed, oestradiol/norethisterone acetate (unknown dose)/day, levothyroxine sodium 50 μg/day, omeprazole 20 mg/day | Certoparia sodium 9000 units/day, thereafter novaminsulfon 1 mL/day | 3 | 3 | recovered/resolved |
12103 | Female | 56 | Colon adenoma ablation | Norethisterone acetate (dose unknown), estradiol (dose unknown), acetylsalicylic acid 750 mg/as needed | No concomitant medications recorded | 1 | 1 | recovered/resolved |
12208 | Male | 66 | Appendectomy | Acarbose 150 mg/day, amlodipine 5 mg/day, clopidogrel sulfate 75 mg/day, fenofibrate 200 mg/day, ferrous sulfate 50 mg/day, glibenclamide 7 mg/day, lisinopril 5 mg/day, simvastatin 20 mg/day | No concomitant medications recorded | 3 | 3 | recovered/resolved |
12307 | Female | 59 | Right knee replacement Lumbar disk surgery | Right knee replacement: diclofenac 75 mg/day (plus physiotherapy) Lumbar disk surgery: ibuprofen 600 mg/as needed, thereafter paracetamol/codeine phosphate 1560 mg/day and metamizole sodium 1500 mg/day | Right knee replacement: diclofenac 150 mg/day, metamizole 1500 mg/day Lumbar disk surgery: oxycodone/naloxone 30 mg/day, tilidine drops (dose unknown)/as needed, fentanyl patch 50 μg/week | 4 | 4 | Right knee replacement: recovered/resolved with sequelae Lumbar disk surgery: recovering/resolving |
12315 | Male | 46 | Meniscus surgery | Acetylsalicylic acid 100 mg/day. | No concomitant medications recorded | 3 | 3 | recovered/resolved |
12401 | Male | 66 | Prostate resection | Bisoprolol hemifumarate 5 mg/day, flecainide acetate 100 mg/day, lansoprazole 15 mg/day, valsartan drops 160 mg/day | No concomitant medications recorded, no chemotherapy, no tumor markers | 4 | 4 | recovered/resolved |
12603 | Female | 63 | Vein stripping (both legs) | Biotin 2.5 mg/week, calcium 500 mg/day, ergocalciferol 0.025 mg/day, estradiol (dose unknown), zinc 25 mg/week, unspecified other urologicals, including antispasmodics. Prior to surgery: 40 mg/day heparin fraction/sodium salt for the prevention of thrombosis | No concomitant medications recorded, compression stockings recorded as therapy | 2 | 2 | recovered/resolved |
12606 | Male | 63 | Vein stripping (right leg) | Acetylsalicylic acid 300 mg/day, allopurinol 300 mg/day, bisoprolol 5 mg/day, insulin 48 IU/day, metformin 850 mg/day, ramipril 1 mg/day | No concomitant medications recorded | 3 | 3 | recovered/resolved |
12701 | Male | 70 | Pelvic bypass surgery | Acetylsalicylic acid 200 mg/day, nafti-ratiopharm retard 400 mg/day | No concomitant medications recorded | 3 | 3 | recovered/resolved with sequelae |
13001 | Female | 72 | Surgery for left orbital fracture | Mesalazine 1500 mg/day, amlodipine 5 mg/day | No concomitant medications recorded | 4 | 4 | recovered/resolved |
13002 | Female | 49 | Hysterectomy | No concomitant medications recorded | No concomitant medications recorded | 4 | 4 | recovered/resolved |
13013 | Female | 75 | Hip replacement (left) Hip replacement (right) | Hip replacement (left) and hip replacement (right):valsartan/hydrochlorothiazide (dose unknown), diclofenac 100 mg/as needed and 75 mg/as needed, diclofenac potassium 50 mg/as needed, lercanidipine 10 mg/day, metoprolol (dose unknown) | Hip replacement (left) and hip replacement (right): no concomitant medications recorded | 0.5 | 0.5 | Hip replacement (left): recovered/resolved Hip replacement (right): recovered/resolved |
13102 | Female | 63 | Vertebral fusion (spondylolisthesis) Vertebral fusion (spondylolisthesis) | Both surgeries: lercanidipine 10 mg/day, pravastatin sodium 40 mg/day, ibuprofen 400 mg/as needed. | Both surgeries: no concomitant medications recorded | 4 | 4 | Both surgeries: recovered/resolved |
14007 | Male | 66 | Osteotomy of right distal tibia | Heparin-fraction/sodium salt 40 mg/day, | Heparin-fraction/sodium salt 40 mg/day, naproxen 1000 mg/day, pantoprazole 20 mg/day | 3 | 3 | recovered/resolved |
17005 | Female | 47 | Hysterectomy | Ibuprofen 600 mg as needed | No concomitant medications recorded | 3 | 3 | recovered/resolved |
17007 | Female | 71 | Hip prosthesis replacement | Chondroitin sulfate sodium 800 mg/day, glucosamine sulfate 1500 mg/day, ibuprofen 400 mg/as needed, paracetamol 600 mg/as needed | Acetylsalicylic acid 300 mg/day, enoxaparin 40 mg/day, alendronate sodium 70 mg/week, calcium 500 mg/day, ciprofloxacin 1500 mg/day, paracetamol 4 g/day, metamizole 150 mg/day, omeprazole 20 mg/day, thiamine nitrate/pyridoxine hydrochloride, clonazepam 2.5 mg/day (for RLS, immediately after surgery) | 4 | 4 | recovering/resolving |
17301 | Male | 71 | Bladder resection | Pentoxifylline 800 mg/day, tamsulosin 0.4 mg/day | No concomitant medications recorded | 4 | 4 | recovered/resolved |