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Table 3 Outcome Measures: white matter lesion quantification

From: The association between cognitive function and white matter lesion location in older adults: a systematic review

Reference Sequence WML Location MRI Magnet
WML Type WML Quantification
Groot et al. [24] PD, T1, T2 S: Four lobes of Frontal, Parietal, Occipital, and Temporal 1.5 T
P, S, Regions Scoring P: Adjacent frontal horns, lateral ventricles wall, and occipital horns
Shenkin et al. [25] T2, FLAIR - 1.5 T
S, P Scoring
Baune et al. [26] PD, T1, T2 - 1.5 T
S, P Scoring
Kim et al. [27] T2, FLAIR - 1.5 T
S, P Volum
Silbert et al. [28] PD, T2 - 1.5 T
S, P Volume
McClleland et al. [21] PD, T1, T2 Cerebral White Matter, Cerebellar White Matter, Basal Ganglia 1.5 T
Regions Scoring
Wright et al. [29] PD, T2, FLAIR Frontal, Deep, and Occipital-Temporal-Parietal 1.5 T
S, I, Regions Volume
Kaplan et al. [30] T2, FLAIR Frontal and Posterior Regions 3.0 T
Regions Volume
Wakefield et al. [31] T1, FLAIR Anterior, Superior, Posterior Corona Radiata 3.0 T
Regions Volume Cingulate Gyrus, Genu, Body, Splenium of Corpus Callusum
Anterior and Posterior Limb of Internal Capsule
Superior Longitudinal Fasciculus
O’Brien et al. [32] T2, FLAIR Internal and External Capsule 1.5 T
Regions Scoring
Smith et al. [14] PD, T1, T2 Whole Brain 1.5 T
Regions Volume
Burns et al. [33] T1, T2 S: Frontal, Parietal, Temporal, and Occipital Lobes 1.5 T
S, P, Regions Scoring P: Right and Left Frontal Horns, Posterior Horns, and Ventricular Bodies
Ishii et al. [34] T2 S: Left and Right 1.5 T
P, S, Regions Scoring P: Anterior and Posterior
Tullberg et al. [35] T1, T2 Orbitofrontal, Prefrontal, Dorsolateral Frontal, Parietal, and Occipitotemporal 1.5 T
Regions Volume   
  1. Abbreviations: PD = Proton Density; FLAIR = Fluid Attenuated Inversion Recovery.