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Table 1 The characteristics and MRI report comparison of 103 CJD patients

From: MRI findings are often missed in the diagnosis of Creutzfeldt-Jakob disease

  Final diagnosis (n) Median age of Onset (min-max) No. DWI sequences (%) No. cases with “CJD-associated changes” on MRI (%) No. cases from neurological centre (%) No. cases with unreported changes from neurological centre (%)
Possible Probable Definite Total NPC review Referring centre
sCJD 3 35 53 91 65 (38–85) 75 (82) 83 (91) 43** (47) 55 (60) 19 (43%)
vCJD   2 5 7 22 (20–53) 6 (86) 7* (100) 7 (100) 5 (71) 0
iCJD   2   2 41 (0) 1 2 0 2 (100) 2 (100)
IPD    3 3   1    - -
E200K    2   67 (63–70) - 2 0 0 -
P102L    1   61 (0) - 1 1 0 -
  1. The scans and corresponding reports of 103 CJD patients were reviewed. The population comprised 91 sCJD, 7 vCJD, 2 iCJD and 3 IPD patients. The number of scans with DWI is shown as is the incidence of CJD-associated changes as noted by NPC and referring centre.
  2. *= 2 of the 7 patients had MRI changes normally associated with sCJD.
  3. **= p<0.0001 compared with NPC opinion of CJD-associated changes using Chi2 with 1df and Yates’ correction.