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Table 2 Pearson correlations between baseline UPSIT, AE, LHCV and APOE and cognitive test scores

From: An olfactory ‘stress test’ may detect preclinical Alzheimer’s disease

  All participantsn= 56
  UP_20 APOE LHCV MMSE ARCSg Mem Flu Lang VS Atten
UPSIT_20 1 −0.04 0.17 0.43** 0.41** 0.39** 0.15 0.19 0.46** 0.40**
AE 0.06 −0.33* 0.53** 0.37** 0.51** 0.57** 0.36** 0.38** 0.28* 0.31*
LHCV 0.17 −0.12 1 0.45** 0.56** 0.57** 0.34* 0.40** 0.43** 0.28*
  Non – Demented n = 42
UPSIT_20 1 −0.05 0.12 0.33* 0.12 0.11 −0.10 −0.02 0.25 0.17
AE −0.15 −0.30 0.49** 0.22 0.50** 0.52** 0.31* 0.29 −0.02 0.21
LHCV 0.12 −0.08 1 0.29 0.44** 0.47** 0.14 0.23 0.23 0.15
  AD n = 14
UPSIT_20 1 0.28 −0.53 −0.17 −0.31 −0.04 −0.42 −0.34 −0.07 0.18
AE −0.05 −0.41 0.52 0.50 0.48 0.47 0.16 0.38 0.46 −0.03
LHCV −0.53 −0.16 1 0.58* 0.80** 0.71** 0.48 0.54 0.59* 0.10
  1. * P < 0.05; ** P < 0.01; UP_20: Score on 20 items of the 40 item University of Pennsylvania Smell Identification Test (UPSIT_20); AE: Atropine Effect; LHCV: Left hippocampal volume adjusted for intracranial volume; APOE: Apolipoprotein E allele dichotomised (no ϵ4 = 0, any ϵ4 = 1); MMSE: Mini Mental State Examination; ARCSg: Scaled global score on the Audio Recorded Cognitive Screen (ARCS); Mem: Scaled memory domain score on the ARCS; Flu: Scaled fluency domain score on the ARCS; Lang: Scaled language domain score on the ARCS; VS: Scaled visuospatial domain score on the ARCS; Atten: Scaled attention/executive domain score on the ARCS.