An olfactory ‘stress test’ may detect preclinical Alzheimer’s disease

BMC Neurology

Table 3 Hierarchical linear regression models predicting memory domain score

Independent variable	ΔR²	ΔF	Standardised Beta	Pvalue
Model 1 (R ² =0.39)
LHCV	0.15	7.9	0.42	0.008
Model 2 (R ² = 0.49)
AE	0.24	17.1	0.51	0.0002
Model 3 (R ² = 0.54)
AE	0.28	19.2	0.54	0.0001
LHCV	0.02	1.28	0.17	0.27
Model 4 (R ² = 0.54)
LHCV	0.147	7.9	0.42	0.008
AE	0.151	10.5	0.46	0.003

LHCV: Left hippocampal volume adjusted for intracranial volume; AE: Atropine Effect.
In all models, age, gender, education were entered first, then baseline UPSIT. In model 3, AE was entered next, followed by LHCV. In model 4, this order was reversed. Restricted to non-demented (n = 39 for analyses including LHCV, n = 42 for model 2).

ISSN: 1471-2377