Table 1 Characteristics of studies included in the met-analyses
From: Phenytoin versus Leviteracetam for Seizure Prophylaxis after brain injury – a meta analysis
Study | Country | Study Design | Population Type | Analyzed | Mean Age (years)* | % Males | Dosage/day | Seizures assessed at | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
PHY | LEV | PHY | LEV | PHY | LEV | PHY | LEV | |||||
Jones et al.[7] | USA | Obs | Severe TBI | 41 | 32 | 34.6 | 33.2 | 75 | 73 | N/A | 1000 mg | 7 Days |
Milligan et al.[12] | USA | Obs | Supra-tentorial surgery | 210 | 105 | 60 | 56.3 | 47 | 39 | 200-800 mg | 500-3000 mg | 7 Days & 30 Days |
Lim et al.[13] | USA | RCT | Glioma (Post Operative) | 8 | 15 | 48.2 | 42 | 100 | 60 | 300-400 mg | 1000-3000 mg | 6 months |
Szaflarski[8] | USA | RCT | TBI, SAH | 18 | 34 | 42 | 45 | 72.2 | 76.5 | 5 mg/kg | 2000-3000 mg | 3 Days & 6 months |
Taylor et al.[14] | USA | Obs | ICH | 25 | 60 | 70.2 | 63.3 | 52 | 40 | NA | 500-2000 mg | Till discharge |
Murphy-Human et al.[15] | USA | Obs | SAH | 297 | 145 | 57 | 55 | 30 | 28 | NA | 1000 mg | 3 Days & Till discharge |