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Table 1 Characteristics of studies included in the met-analyses

From: Phenytoin versus Leviteracetam for Seizure Prophylaxis after brain injury – a meta analysis

Study Country Study Design Population Type Analyzed Mean
Age
(years)*
% Males Dosage/day Seizures assessed at
     PHY LEV PHY LEV PHY LEV PHY LEV  
Jones et al.[7] USA Obs Severe TBI 41 32 34.6 33.2 75 73 N/A 1000 mg 7 Days
Milligan et al.[12] USA Obs Supra-tentorial surgery 210 105 60 56.3 47 39 200-800 mg 500-3000 mg 7 Days & 30 Days
Lim et al.[13] USA RCT Glioma
(Post Operative)
8 15 48.2 42 100 60 300-400 mg 1000-3000 mg 6 months
Szaflarski[8] USA RCT TBI, SAH 18 34 42 45 72.2 76.5 5 mg/kg 2000-3000 mg 3 Days & 6 months
Taylor et al.[14] USA Obs ICH 25 60 70.2 63.3 52 40 NA 500-2000 mg Till discharge
Murphy-Human et al.[15] USA Obs SAH 297 145 57 55 30 28 NA 1000 mg 3 Days & Till discharge
  1. Obs Observational study, RCT Randomized Controlled Trial, LEV Levetiracetam, PHY Phenytoin, TBI Traumatic brain injury, ICH Intracranial hemorrhage, SAH Subarachnoid hemorrhage.
  2. * Mean age has been estimated wherever not directly available.