Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study

BMC Neurology

Table 3 Summary of response at month 12 with subgroup analysis according to type of disease and MSFC subcategories (mITT population, LOCF method)

		Placebo	Masitinib
		All (n = 6)	All (n = 24)	PPMS (n = 9)	SPMS (n = 15)
Relative change in MSFC score _*	Mean ± SD	-60% ± 190	103% ± 189	134% ± 268	84% ± 130
Relative change in T25FW	Mean ± SD	26% ± 55	5% ± 26	13% ± 17	-1% ± 29
Relative change in 9-HPT	Mean ± SD	0% ± 13	-7% ± 9	-5% ± 7	-8% ± 10
Relative change in PASAT-3”	Mean ± SD	24% ± 30	41% ± 111	19% ± 66	55% ± 131
Absolute change in EDSS score	Mean ± SD	0.3 ± 1.0	0.0 ± 0.5	0.1 ± 0.4	0.0 ± 0.5

* Change from to baseline. In the primary endpoint of MSFC an increase represents an improvement in MS-related impairment. mITT = modified intent to treat. LOCF = last observation carried forward. MSFC = multiple sclerosis functional composite score. T25FW = timed 25-foot walk test. 9-HPT = nine hole peg test. PASAT-3” = Paced Auditory Serial Addition Test 3 seconds. EDSS = expanded disability status scale.

ISSN: 1471-2377