Table 3 SIR for subsequent hemorrhagic stroke of patients with IMD

<1

1-5

5-10

> = 10

All

Immune-mediated diseases

O

SIR

95% CI

O

SIR

95% CI

O

SIR

95% CI

O

SIR

95% CI

O

SIR

95% CI

Addison´s disease

2

2.70

0.25

9.94

2

0.64

0.06

2.34

1

0.42

0.00

2.41

1

0.55

0.00

3.17

6

0.74

0.27

1.63

Amyotrophic lateral sclerosis

1

0.47

0.00

2.68

2

1.30

0.12

4.78

1

1.82

0.00

10.42

0

4

0.89

0.23

2.30

Ankylosing spondylitis

6

8.11

2.92

17.76

15

3.43

1.92

5.68

7

1.66

0.66

3.44

14

2.28

1.24

3.84

42

2.72

1.96

3.67

Autoimmune hemolytic anemia

1

3.13

0.00

17.91

4

2.96

0.77

7.66

1

1.15

0.00

6.59

2

2.99

0.28

10.98

8

2.49

1.06

4.93

Behcet´s disease

1

33.33

0.01

191.08

0

0

0

1

1.67

0.00

9.55

Celiac disease

2

3.57

0.34

13.13

6

2.08

0.75

4.56

7

2.69

1.07

5.58

8

2.65

1.13

5.25

23

2.54

1.61

3.81

Chorea minor

0

0

0

0

0

Crohn disease

5

1.47

0.46

3.46

47

2.60

1.91

3.46

19

1.19

0.72

1.87

24

1.57

1.00

2.34

95

1.80

1.46

2.21

Diabetes mellitus type I

0

2

2.50

0.24

9.19

1

1.11

0.00

6.37

2

1.01

0.09

3.70

5

1.32

0.42

3.10

Discoid lupus erythematosus

1

11.11

0.00

63.69

1

2.33

0.00

13.33

0

0

2

1.87

0.18

6.87

Grave´s disease

8

1.53

0.65

3.02

58

1.77

1.35

2.29

48

1.61

1.18

2.13

41

1.48

1.06

2.02

155

1.62

1.38

1.90

Hashimoto´s thyroiditis

4

1.47

0.38

3.79

27

2.01

1.32

2.93

19

2.10

1.26

3.29

11

1.37

0.68

2.46

61

1.84

1.40

2.36

Immune thrombocytopenic purpura

8

8.60

3.67

17.03

12

2.81

1.45

4.92

6

2.18

0.79

4.78

2

1.23

0.12

4.54

28

2.93

1.94

4.23

Localized scleroderma

0

1

0.93

0.00

5.36

1

0.85

0.00

4.90

6

4.32

1.55

9.46

8

2.11

0.90

4.17

Lupoid hepatitis

0

0

0

0

0

Multiple sclerosis

4

1.82

0.47

4.70

15

1.36

0.76

2.25

9

1.09

0.49

2.08

6

0.94

0.34

2.06

34

1.22

0.84

1.71

Myasthenia gravis

1

1.22

0.00

6.99

8

2.09

0.89

4.14

6

2.17

0.78

4.76

0

15

1.62

0.90

2.68

Pernicious anemia

4

2.15

0.56

5.56

18

1.67

0.99

2.65

13

1.52

0.81

2.61

7

0.99

0.39

2.06

42

1.49

1.07

2.01

Polyarteritis nodosa

2

5.41

0.51

19.88

0

0.00

0.54

2.19

3

1.91

0.36

5.66

0

5

1.00

0.31

2.34

Polymyalgia rheumatica

21

2.06

1.28

3.16

78

1.42

1.12

1.77

65

1.67

1.29

2.13

40

1.49

1.06

2.03

204

1.56

1.35

1.79

Polymyositis/ dermatomyositis

1

2.63

0.00

15.08

3

1.95

0.37

5.77

1

1.18

0.00

6.74

1

2.08

0.00

11.94

6

1.85

0.66

4.04

Primary biliary cirrhosis

1

2.08

0.00

11.94

3

1.76

0.33

5.22

2

2.17

0.20

7.99

0

6

1.87

0.67

4.10

Psoriasis

9

2.88

1.31

5.50

32

1.83

1.25

2.59

23

1.51

0.95

2.26

21

1.32

0.81

2.02

85

1.64

1.31

2.03

Reiter´s disease

0

1

2.94

0.00

16.86

1

2.56

0.00

14.70

0

2

1.42

0.13

5.22

Rheumatic fever

1

7.69

0.00

44.09

0

0

1

1.72

0.00

9.88

2

1.04

0.10

3.81

Rheumatoid arthritis

65

3.27

2.52

4.17

191

2.03

1.76

2.34

109

1.92

1.57

2.31

61

1.78

1.36

2.29

426

2.08

1.89

2.29

Sarcoidosis

3

2.48

0.47

7.34

12

1.87

0.96

3.28

14

2.26

1.23

3.80

6

0.79

0.28

1.73

35

1.64

1.14

2.28

Sjögren´s syndrome

0

3

1.35

0.25

4.00

2

1.03

0.10

3.77

0

5

0.81

0.26

1.90

Systemic lupus erythematosus

9

8.65

3.92

16.50

13

2.89

1.53

4.95

4

1.17

0.31

3.03

6

1.91

0.69

4.19

32

2.65

1.81

3.74

Systemic sclerosis

2

3.17

0.30

11.67

5

2.67

0.84

6.29

3

2.73

0.51

8.07

2

3.45

0.33

12.68

12

2.87

1.48

5.03

Ulcerative colitis

7

1.45

0.57

3.00

40

1.45

1.03

1.97

28

1.21

0.80

1.74

33

1.44

0.99

2.02

108

1.37

1.13

1.66

Wegener´s granulomatosis

6

5.83

2.10

12.76

3

0.90

0.17

2.67

2

1.08

0.10

3.95

0

11

1.47

0.73

2.63

All

175

2.65

2.27

3.08

602

1.83

1.69

1.98

396

1.63

1.47

1.80

295

1.47

1.31

1.65

1468

1.75

1.66

1.84