Figure 4

Time course of MEP amplitudes of patients with NF1 after PAS with and without lovastatin. A) Shown are data from the NF1 patients (n = 11). Abscissa depicts point in time and ordinate mean MEP amplitude. Administration of lovastatin 4 days before PAS led to a rescue of motor cortex plasticity in patients. Asterisks indicate significant differences between the two drug conditions (p < 0.05, paired t test) and error bars represent ± standard error of the mean. B) MEP amplitudes from one representative subject for placebo and lovastatin condition before and at POST 1 after PAS. Shown are averages of 20 MEP trials in each case.