Figure 7From: Blood-brain barrier impairment in MPS III patients Immunohistochemical staining for lysosomes within capillary endothelium in cerebellum of MPS III patients. (A, C) Cerebellum control tissues contained capillaries with little lysosomal immunoexpression (arrows, green). A morphologically normal Purkinje cell with its dendrites was seen (C). Increasing LAMP-1 immunoreactivity within capillary endothelium was determined in cerebellum of (B) MPS III A (green, arrows) and (D, E) MPS III D (green, arrows). Arrows and arrowheads indicate LAMP-1 (green) and collagen IV (red) immunoexpressions, respectively. Magnification in A-E is 40x. (F) Semi-quantitative analysis of LAMP-1 immunoreactivity showed similar high lysosomal marker expressions within capillary endothelium in MPS III A and III D cerebellums vs. controls.Back to article page