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Table 1 Characteristic of serological studies

From: Chlamydia pneumoniae infection and cerebrovascular disease: a systematic review and meta-analysis

Author Y Country Study design Number of case/control Case assessment or endpoint Serologic testing assay Laboratory test/Marker Adjustment
Bandaru VC 2012 India CSCC 100/100 Ischemic stroke MIF IgA, IgG Age, gender, diabetes, smoking, hypercholesterolemia, hyperhomocysteinemia.
Hasan ZN 2011 Iraq CSCC 50/40 Ischemic stroke ELISA IgA, IgG None
Kēnina V 2011 Latvija CSCC 102/48 Ischemic stroke ELISA IgG None
Chen YJ 2010 China CSCC 50/50 Ischemic stroke MIF IgG None
Bandaru VC 2009 India CSCC 120/120 Ischemic stroke MIF IgA, IgG None
Bandaru VC 2009 India CSCC 120/120 Ischemic stroke MIF IgA, IgG None
Tiszlavicz Z 2009 Hungary CSCC 280/150 Ischemic stroke ELISA IgG None
Alavi SM 2009 Iran CSCC 45/45 Ischemic stroke ELISA IgG None
Bandaru VC 2008 India CSCC 200/200 Ischemic stroke MIF IgA, IgG Age, diabetes, smoking, alcoholics, hypertension, hyperhomocystenemia, hypercholestemia.
Lin TM 2008 China CSCC 450/450 Ischemic stroke MIF IgG Gender, hypertension, diabetes, hypercholesterolemia, and smoking.
Hu J 2008 China CSCC 100/60 Ischemic stroke, TIA ELISA IgG None
Kis Z 2007 Hungary CSCC 59/52 Ischemic stroke ELISA IgA, IgG Age, gender
Alamowitch S 2007 France CSCC 483/483 Ischemic stroke MIF IgA, IgG Diabetes, smoking, hypertension, total cholesterol, CHD, season of enrolment.
Piechowski JB 2007 Poland CSCC 94/103 Ischemic stroke ELISA IgA, IgG Age and gender
Chi LQ 2007 China CSCC 50/48 Ischemic stroke ELISA IgG None
Liu JX 2006 China CSCC 47/48 Ischemic stroke ELISA IgG None
Njamnshi AK 2006 Cameroon CSCC 64/64 Ischemic stroke, TIA MIF IgA, IgG Diabetes, smoking, hypertension, obesity and alcohol intake.
Elkind MS 2006 USA CSCC 239/428 Ischemic stroke MIF IgA, IgG Age, gender, diabetes, smoking, atrial fibrillation, hypertension, HDL, LDL and race.
Chen L 2006 China CSCC 135/135 Ischemic stroke ELISA IgG None
Liu AM 2006 China CSCC 80/80 Stroke MIF IgA, IgG None
Zhou B 2005 China CSCC 76/80 Ischemic stroke EIA IgA Age, gender, smoking, alcohol intake, body weight, hypertension, cholesterol, hypertention.
Johsen SP 2005 Denmark NCC 254/254 Ischemic stroke ELISA IgA, IgG Diabetes, smoking, hypertension, cholesterol, BMI, alcohol intake, and education.
Li FL 2004 China CSCC 65/25 Stroke ELISA IgA, IgG, IgM None
Anzini A 2004 Italy CSCC 141/192 Ischemic stroke MIF IgA, IgG, IgM Age, gender, CV risk factors and socioeconomic status.
Manuela V 2004 Netherlands CSCC 41/55 Ischemic stroke ELISA IgA, IgG Smoking, hypertension and hypercholesterolemia.
Apfalter P 2004 Australia CSCC 45/30 Stroke, TIA MIF IgA, IgG, IgM None
Carusone CS 2004 Canada CSCC 28/24 Stroke MIF IgA, IgG Age, gender and smoking.
Bucurescu G 2003 USA CSCC 25/25 Stroke, TIA MIF IgA, IgG None
Ngeh J 2003 UK CSCC 100/87 Stroke, TIA ELISA IgA, IgG, IgM Age, gender, smoking, diabetes, hypertension, CHD.
Kawamoto R 2003 Japan CSCC 40/85 Ischemic stroke ELISA IgG None
Sirmatel F 2003 Turkey CSCC 26/53 Ischemic stroke MIF IgG None
Zou R 2003 China CSCC 112/50 Stroke ELISA IgM, IgG None
Wolf SC 2003 Germany CSCC 30/116 Ischemic stroke ELISA IgA, IgG Age, gender, diabetes, match for other risks factors.
Sessa R 2003 Italy CSCC 18/33 Ischemic stroke,TIA MIF IgA, IgG None
Smiega M 2003 Canada NCC 107/3061 Stroke MIF IgA ,IgG Age, gender, diabetes, smoking, hypertension, and hypercholesterolemia.
Tanne D 2003 Israel NCC 134/134 Ischemic stroke ELISA IgA, IgG Diabetes, smoking, BMI, hypertension.
Katie A C 2003 Australia PC 119/1493 Stroke MIF IgA, IgG Age, gender, diabetes, smoking, BMI, hypertension, cholesterol, TG, hemoglobin and systolic blood pressure.
Gerdes v 2002 Netherlands NCC 26/273 Ischemic stroke ELISA IgA, IgG None
Madre JG 2002 Spain CSCC 91/112 Ischemic stroke MIF IgA None
Tarnacka B 2002 Poland CSCC 20/15 Sympotomatic carotid disease ELISA IgG None
LaBiche R 2001 USA CSCC 36/55 Sympotomatic carotid disease MIF IgA, IgG, IgM None
Katsenis C 2001 Greece CSCC 20/15 Sympotomatic carotid disease ELISA IgM None
Elkind MS 2000 USA CSCC 89/89 Ischemic stroke MIF IgA, IgG Diabetes, smoking, hypertension, HDL, education, match for age, gender, race.
Glader CA 1999 Sweden NCC 97/197 Ischemic stroke MIF IgA, IgG Diabetes, smoking, BMI, hypertension, hypercholesterolmia.
Wimmer MLJ 1996 Germany CSCC 58/52 Ischemic stroke,TIA MIF IgA, IgG Age, gender, hypertension, migraine.
  1. CSCC, cross-sectional case control; NCC, nested case control; PC, prospective case–control or cohort; ELISA, enzyme-linked immunosorbent assay; MIF, microimmunonuorescence; HDL ,high density lipoprotein; LDL, low density lipoprotein;TG, triglycerides; CHD, coronary heart disease; BMI, body mass index; TIA, transient ischemic attack; CV, cerebrovascular.