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Table 1 Demographic and clinical characteristics, presence of symptoms of depression and midbrain 123 I-ADAM binding potential to SERT of individual patients

From: 123I-ADAM SPET imaging of serotonin transporter in patients with epilepsy and comorbid depression

Age (years)

Sex

Age at onset (years)

Duration of epilepsy (years)

Frequency of seizures

Syndrome

Localization

Interictal EEG

LTM

MRI

AEDs (daily dose, mg)

Symptoms of depression

123I-ADAM binding to SERT

32

M

17

15

2-5/mo

Generalized

N/A

Generalized spike-wave activity

Not performed

Normal

LEV (2000)

No

1.3

VPA (1800)

LTG (75)

24

F

5

19

1/mo

Generalized

N/A

Generalized spike-wave activity

Not performed

Normal

VPA (1500)

No

1.39

OXC (1200)

36

M

21

15

1/year

Generalized

N/A

Negative

Not performed

Normal

VPA (600)

No

0.87

21

F

15

6

3/week

Generalized

N/A

Generalized spike-wave activity

Generalized tonic.clonic seizures

Normal

LTG (400)

Yes

1.36

OXC (600)

55

M

23

32

1/mo

Generalized

N/A

Generalized spike-wave activity

Not performed

Normal

VPA (2000)

Yes

1.16

LTG (150)

39

M

27

12

2/year

Focal

Left temporal

Left temporal interictal discharges

Left temporal ictal activity

Small cysts in left temporomesial structures, hippocampus and amygdala

LTG (250)

No

1.42

40

F

24

16

4-5/mo

Focal

Left temporomesial

Left temporal interictal discharges

Left temporal ictal activity

Colloidal cyst in left frontotemporal regions

PB (50)

No

1.1

LTG (200)

38

M

22

16

1/mo

Focal

Left temporal

Negative

Not performed

Hippocampal atrophy on the left side

OXC (1800)

Yes

0.98

VPA (900)

42

M

4

38

4-6/mo

Focal

Right temporomesial

Right temporal interictal discharges

Right temporal ictal activity

Mesial temporal sclerosis on the right side

PHT (375)

Yes

1.28

42

F

14

28

2/mo

Focal

Right frontal

Negative

Right frontal ictal activity

2 small hyperintensive lesions in the right parietal lobe

OXC (1800)

Yes

1.46

34

F

7

27

4-5/week

Focal

Left temporomesial

Left temporal interictal discharges

Left temporal ictal activity

Mesial temporal sclerosis on the left side

VPA (1000)

Yes

1.32

TPM (100)

32

M

2

30

3/week

Focal

Right temporomesial

Right temporal interictal discharges

Right temporal ictal activity

Mesial temporal sclerosis on the right side

OXC (1800)

Yes

1.26

          

TPM (400)

  
  1. EEG – electroencephalography; LTM – long-term monitoring; MRI – magnetic resonance imaging; AEDs – antiepileptic drugs; LEV – levetiracetam; VPA – valproate; LTG – lamotrigin; OXC – oxcarbazepine; PB – phenobarbital; PHT – phenytoin; TPM – topiramate; 123I-ADAM – 2-((2-((dimethylamino)methyl)phenyl)thio)-5-(123)iodophenylamine; SERT – serotonin transporter.
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BMC Neurology

ISSN: 1471-2377

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