Table 2 LINGO1 genotype and allelic variants of patients with multiple sclerosis (MS) and healthy volunteers
From: LINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis
MS PATIENTS (N = 293, 586 ALLELES) | CONTROLS (N = 318, 636 ALLELES) | Intergroup comparison values | MS WOMEN (N = 203, 406 ALLELES) | CONTROL WOMEN (N = 221, 442 ALLELES) | Intergroup comparison values | MS MEN (N = 90, 180 ALLELES) | CONTROL MEN (N = 97, 194 ALLELES) | Intergroup comparison values | |
|---|---|---|---|---|---|---|---|---|---|
rs9652490 GENOTYPE A/A | 197 (67.2%) | 222 (69.8%) | 139 (68.5%) | 153 (69.2%) | 58 (64.4%) | 69 (71.1%) | |||
A/G | 92 (31.4%) | 86 (27.0%) | P = 0.197 | 62 (30.5%) | 60 (27.1%) | P = 0.170 | 30 (33.3%) | 26 (26.8%) | P = 0.651 * |
G/G | 4 (1.4%) | 10 (3.1%) | 2 (1.0%) | 8 (3.6%) | 2 (2.2%) | 2 (2.1%) | |||
Allele A | 486 (82.9%) | 530 (83.3%) | -- | 340 (83.7%) | 366 (82.8%) | -- | 146 (81.1%) | 164 (84.5%) | -- |
Allele G | 100 (17.1%) | 106 (16.7%) | OR (95% CI) | 66 (16.3%) | 76 (17.2%) | OR (95% CI) | 34 (18.9%) | 30 (15.5%) | OR (95% CI) |
1.03 (0.76-1.39) | 0.94 (0.65-1.34) | 1.27 (0.74-2.18) | |||||||
P = 0.853 | P = 0.715 | P = 0.380 | |||||||
rs11856808 GENOTYPE C/C | 137 (46.8%) | 145 (45.6%) | 95 (46.8%) | 101 (45.7%) | 42 (46.7%) | 44 (45.4% | |||
C/T | 126 (43.0%) | 149 (46.9%) | P = 0.407 | 90 (44.3%) | 103 (46.6%) | P = 0.852 | 36 (40.0%) | 46 (47.4%) | P = 0.313 |
T/T | 30 (10.2%) | 24 (7.5%) | 18 (8.9%) | 17 (7.7%) | 12 (13.3%) | 7 (7.2%) | |||
Allele C | 400 (68.3%) | 439 (69.0%) | -- | 280 (69.0%) | 305 (69.0%) | -- | 120 (66.7%) | 134 (69.1%) | -- |
Allele T | 186 (31.7%) | 197 (31.0%) | OR (95% CI) | 126 (31.0%) | 137 (31.0%) | OR (95% CI) | 60 (33.3%) | 60 (30.9%) | OR (95% CI) |
1.04 (0.81-1.32) | 1.00 (0.75-1.34) | 1.08 (0.60-1.43) | |||||||
P = 0.773 | P = 0.990 | P = 0.725 |