Table 3 Baseline characteristics of study participants in the 183 included articles

Baseline demographics

  Median number of patients

32

(21 to 53)

31

(16 to 36)

34

(22 to 55)

0.058

  Mean age (years)

63.5

(5.6)

63.7

(6.7)

63.4

(5.5)

0.771

  Mean percentage male

58.7

(13.9)

67.3

(15.6)

57.7

(13.3)

0.002

  Median disease duration (years)

5.7

(3.6 to 7.4)

3.2

(1.7 to 5.9)

5.9

(4.1 to 7.6)

0.005

  Median percentage treated

76.8

(51.2 to 88.8)

40.6

(0.0 to 71.1)

78.5

(56.7 to 90.2)

0.005

Baseline disease severity

  Median total UPDRS

33.3

(29.4 to 40.6)

31.8

(30.1 to 38.7)

33.3

(29.4 to 40.6)

0.790

  Median UPDRS (II)

14.7

(11.6 to 16.3)

9.1

(Insufficient data for IQR)

14.8

(11.9 to 16.6)

0.023

  Median UPDRS (III)

21.0

(16.6 to 26.3)

22.4

(16.3 to 28.5)

20.9

(16.8 to 25.8)

0.864

  Median Hoehn & Yahr

2.5

(2.0 to 2.8)

1.8

(1.6 to 2.0)

2.5

(2.1 to 2.9)

<0.001

  Median MMSE

25.8

(23.0 to 28.1)

25.5

(22.3 to 28.3)

25.8

(23.0 to 28.1)

1.000