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Figure 1 | BMC Neurology

Figure 1

From: POLG1 mutations and stroke like episodes: a distinct clinical entity rather than an atypical MELAS syndrome

Figure 1

A-D: Skeletal muscle biopsy showing one ragged red fiber with histological methods (A-B: H&E, 10X ; B: GT, 40X). Histochemical reactions for COX (C, 10X) and COX-SDH (D, 10X) in cross serial sections show lack of COX activity in several skeletal muscle fibers (C), many of which also show increased SDH activity (D).E-H: Axial T2-weighted cerebral MRI sequences showing a cortico-subcortical fronto-parietal hyperintensity with restricted diffusion (not shown) consistent with acute ischaemic lesion and bilateral old ischaemic lesions in the right occipital and left temporal lobe.

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BMC Neurology

ISSN: 1471-2377

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