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Table 2 Results of the association between CTSD C224T polymorphism and AD risk in the meta-analysis

From: Lack of association between cathepsin D C224T polymorphism and Alzheimer’s disease risk: an update meta-analysis

Comparison Population No. of studies Test of association Mode Test of heterogeneity
    OR 95% CI P Value   x 2 PQValue I2
 CT vs. CC Overall 25 1.125 0.974–1.299 0.109 R 39.65 0.023 39.5
 CT + TT vs. CC Overall 25 1.136 0.978–1.320 0.094 R 44.23 0.007 45.7
Subgroup analysis
Ethnicity          
 CT vs. CC Asian 4 0.971 0.626–1.506 0.895 F 2.04 0.565 0.0
  Caucasian 21 1.139 0.974–1.331 0.102 R 37.20 0.011 46.2
 CT + TT vs. CC Asian 4 0.954 0.616–1.477 0.833 F 2.04 0.565 0.0
  Caucasian 21 1.154 0.982–1.357 0.082 R 41.54 0.003 51.8
EOAD          
 CT vs. CC Overall 6 0.937 0.706–1.245 0.654 F 2.87 0.719 0.0
 CT + TT vs. CC Overall 6 0.93 0.704–1.229 0.612 F 2.68 0.749 0.0
LOAD          
 CT vs. CC Overall 6 0.935 0.724–1.207 0.606 F 3.86 0.57 0.0
 CT + TT vs. CC Overall 6 0.931 0.726–1.195 0.575 F 3.88 0.567 0.0
  1. OR, odds ratio; CI, confidence intervals; R, random effects model; F, fixed effects model; EOAD, early-onset AD; LOAD ,late-onset AD.