Lack of association between cathepsin D C224T polymorphism and Alzheimer’s disease risk: an update meta-analysis

BMC Neurology

Table 2 Results of the association between CTSD C224T polymorphism and AD risk in the meta-analysis

Comparison	Population	No. of studies	Test of association			Mode	Test of heterogeneity
			OR	95% CI	P Value		x ²	P_QValue	I²
CT vs. CC	Overall	25	1.125	0.974–1.299	0.109	R	39.65	0.023	39.5
CT + TT vs. CC	Overall	25	1.136	0.978–1.320	0.094	R	44.23	0.007	45.7
Subgroup analysis
Ethnicity
CT vs. CC	Asian	4	0.971	0.626–1.506	0.895	F	2.04	0.565	0.0
	Caucasian	21	1.139	0.974–1.331	0.102	R	37.20	0.011	46.2
CT + TT vs. CC	Asian	4	0.954	0.616–1.477	0.833	F	2.04	0.565	0.0
	Caucasian	21	1.154	0.982–1.357	0.082	R	41.54	0.003	51.8
EOAD
CT vs. CC	Overall	6	0.937	0.706–1.245	0.654	F	2.87	0.719	0.0
CT + TT vs. CC	Overall	6	0.93	0.704–1.229	0.612	F	2.68	0.749	0.0
LOAD
CT vs. CC	Overall	6	0.935	0.724–1.207	0.606	F	3.86	0.57	0.0
CT + TT vs. CC	Overall	6	0.931	0.726–1.195	0.575	F	3.88	0.567	0.0

OR, odds ratio; CI, confidence intervals; R, random effects model; F, fixed effects model; EOAD, early-onset AD; LOAD ,late-onset AD.

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