|
Comparison
|
Population
|
No. of studies
|
Test of association
|
Mode
|
Test of heterogeneity
|
|---|
| | | |
OR
|
95% CI
|
P Value
| |
x
2
|
PQValue
|
I2
|
|---|
|
CT vs. CC
|
Overall
|
25
|
1.125
|
0.974–1.299
|
0.109
|
R
|
39.65
|
0.023
|
39.5
|
|
CT + TT vs. CC
|
Overall
|
25
|
1.136
|
0.978–1.320
|
0.094
|
R
|
44.23
|
0.007
|
45.7
|
|
Subgroup analysis
|
|
Ethnicity
| | | | | | | | | |
|
CT vs. CC
|
Asian
|
4
|
0.971
|
0.626–1.506
|
0.895
|
F
|
2.04
|
0.565
|
0.0
|
| |
Caucasian
|
21
|
1.139
|
0.974–1.331
|
0.102
|
R
|
37.20
|
0.011
|
46.2
|
|
CT + TT vs. CC
|
Asian
|
4
|
0.954
|
0.616–1.477
|
0.833
|
F
|
2.04
|
0.565
|
0.0
|
| |
Caucasian
|
21
|
1.154
|
0.982–1.357
|
0.082
|
R
|
41.54
|
0.003
|
51.8
|
|
EOAD
| | | | | | | | | |
|
CT vs. CC
|
Overall
|
6
|
0.937
|
0.706–1.245
|
0.654
|
F
|
2.87
|
0.719
|
0.0
|
|
CT + TT vs. CC
|
Overall
|
6
|
0.93
|
0.704–1.229
|
0.612
|
F
|
2.68
|
0.749
|
0.0
|
|
LOAD
| | | | | | | | | |
|
CT vs. CC
|
Overall
|
6
|
0.935
|
0.724–1.207
|
0.606
|
F
|
3.86
|
0.57
|
0.0
|
|
CT + TT vs. CC
|
Overall
|
6
|
0.931
|
0.726–1.195
|
0.575
|
F
|
3.88
|
0.567
|
0.0
|
-
OR, odds ratio; CI, confidence intervals; R, random effects model; F, fixed effects model; EOAD, early-onset AD; LOAD ,late-onset AD.
