Table 1 Synopsis with methodological characteristics of the sifap1 study

Study objectives

 Primary objectives

To determine the prevalence of Fabry disease in young stroke patients

 Secondary objectives

To describe patterns of stroke in young patients

Inclusion criteria

 Age

18–55 years

 Time since event

Less than 3 months before inclusion into the study

 Diagnosis

Acute CVE of any aetiology (ischemic stroke, TIA, intracranial haemorrhage)

 Verification of diagnosis

Verification of brain infarction or haemorrhage by

MRI scan.

In case of negative MRI diagnosis confirmed by stroke-experienced neurologist (more than 2 years of experience in stroke and at least 6 years of experience in general neurology)

 Diagnostic information

MRI documentation available

Diagnostic procedures according to EUSI/ESO

recommendations

 Ethics

Written informed consent from patient or legal

representative according to local ethics committee

regulations

Inclusion period

April 2007 till January 2010

Number of participating countries

15

Number of centres

47

Number of included patients

5023

Overall inclusion rate in the 7 best recruiting centres

52.9%