Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

Table 3 Correlation coefficients between peak peripheral inflammatory markers and outcome measures

	CT brain infarct volume (cm³)	NIHSS score at 5 to 7 days	mRS 3 months	BI 3 months	mRS 12 months	BI 12 months
Peak plasma CRP (mg/l)	0.66 (p < 0.001)	0.54 (p = 0.001)	0.63 (p < 0.001)	-0.58 (p < 0.001)	0.65 (p < 0.001)	-0.63 (p < 0.001)
Peak WBC count (×10⁹/l)	0.41 (p = 0.04)	0.51 (p = 0.003)	0.65 (p < 0.001)	-0.67 (p < 0.001)	0.73 (p < 0.001)	-0.67 (p < 0.001)
Peak ESR (mm/hr)	0.57 (p = 0.007)	0.28 (p = 0.16)	0.29 (p = 0.15)	-0.34 (p = 0.09)	0.48 (p = 0.02)	-0.41 (p = 0.05)
Peak plasma cortisol (nmol/l)	0.26 (p = 0.19)	0.37 (p = 0.03)	0. (p = 0.005)	-0.48 (p = 0.005)	0.49 (p = 0.006)	-0.46 (p = 0.01)
Peak aural temperature (°C)	0.37 (p = 0.05)	-0.05 (p = 0.76)	-0.04 (p = 0.82)	0.08 (p = 0.67)	0.01 (p = 0.98)	-0.02 (p = 0.92)

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