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Table 3 Frequency of the THBD Ala455Val AA genotype in cases and controls (proportion with AA genotype in parentheses) as stratified by race and other stroke risk factors; with associated crude and adjusted odds ratios

From: Thrombomodulin Ala455Val Polymorphism and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study

Risk Factor Percentage of cases with the AA genotype (proportion) Percentage of Controls with the AA genotype (proportion) Crude OR ^ (95% CI) Adjusted OR*^ (95% CI)
White 79% (62/79) 68% (93/137) 1.7 (0.9–3.3) 1.6 (0.8–3.2)
Black 87% (54/62) 81% (59/73) 1.8 (0.4–7.9) 2.7 (0.9–8.0)
Current smoking 84% (54/64) 71% (40/56) 2.2 (0.9–5.3) 3.0 (1.1–7.8)
No current smoking 81% (62/77) 73% (112/154) 1.6 (0.8–3.0) 1.5 (0.7–2.9)
Hypertension 85% (33/39) 61% (17/28) 3.6 (1.1–11.3) 5.7 (1.4–22.6)
No hypertension 81% (83/102) 74% (135/182) 1.5 (0.8–2.8) 1.6 (0.8–3.0)
Diabetes** 84% (16/19) 86% (6/7) Not performed Not performed
No Diabetes 82% (100/122) 72% (146/203) 1.8 (1.0–3.1) 1.9 (1.1–3.4)
Angina/MI ** 86% (18/21) 56% (5/9) Not performed Not performed
No Angina/MI 82% (98/120) 73% (147/201) 1.6 (0.9–2.9) 1.7 (.95–3.1)
Overall 82% (116/141) 72% (152/210) 1.8 (1.1–3.0) 1.9 (1.1–3.3)
  1. * Each variable adjusted for age, race, smoking, hypertension, and diabetes (less the stratified variable). Overall model and Angina/MI adjusted for age, race, smoking, hypertension, and diabetes. Including Angina/MI in adjusted overall model demonstrated no change in association (OR = 1.9 95% CI = 1.1–3.3).
  2. ** Insufficient sample size to perform diabetic or angina/MI analyses.
  3. ^ The combined AV and VV genotypes within each strata serve as the reference group in all analyses, with the crude OR and adjusted OR assigned a reference value of 1.0.