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Table 1 Characteristics of AVM patients enrolled in a pilot clinical study to test effects of oral doxycycline treatment on MMP-9 in AVM lesions.

From: Suppression of MMP-9 by doxycycline in brain arteriovenous malformations

Group

Age

Gender

S-M score*

AVM size**

Draining veins

History of hemorrhage

Number of embolization treatments

Dox

50

M

4

38

Superficial & Deep

No

1

Dox

48

F

4

30

Deep

Yes

0

Dox

52

M

4

42

Superficial & Deep

Yes

2

Dox

43

M

3

29

Superficial & Deep

No

1

Dox

23

M

4

34

Superficial & Deep

No

2

Dox

28

M

4

40

Superficial

Yes

2

Dox

56

M

2

10

Superficial

No

 

Dox

41

F

3

30

Superficial

No

1

Dox

62

M

2

41

Superficial

No

1

Dox

42

M

2

2

Superficial

Yes

0

Placebo

53

M

2

28

Superficial & Deep

No

1

Placebo

17

M

1

18

Superficial

No

1

Placebo

48

F

2

13

Deep

No

0

Placebo

22

M

3

19

Deep

Yes

0

  1. * Spetzler-Martin score (15), **AVM maximum diameter (10). Dox = doxycycline