Table 4 The % (n) of subjects reporting symptoms and diagnosed Parkinson's disease, by 10-year age group and for PD cases
From: Self-reported parkinsonian symptoms in the EPIC-Norfolk cohort
Age Group, Years (N) | ||||||||
|---|---|---|---|---|---|---|---|---|
Excluding individuals with any missing symptom answers | ||||||||
Symptom | 40–49 (818) | 50–59 (4008) | 60–69 (3849) | 70–79 (2803) | 80+ (61) | All Ages (11 539) | P- value for age trend* | PD Cases (53) |
Resting Tremor | 3.9 (32) | 3.6 (144) | 4.3 (166) | 5.4 (150) | 6.6 (4) | 4.3 (496) | 0.0008 | 49.1 (26) |
Difficulty Walking | 4.7 (38) | 5.0 (200) | 3.8 (147) | 3.9 (110) | 6.6 (4) | 4.3 (499) | 0.0435 | 35.9 (19) |
Difficulty Chair | 6.6 (54) | 6.4 (255) | 5.7 (220) | 7.2 (203) | 8.2 (5) | 6.4 (737) | 0.3255 | 39.6 (21) |
Walking Slower | 11.3 (92) | 19.6 (787) | 35.9 (1383) | 57.3 (1607) | 70.5 (43) | 33.9 (3912) | <0.0001 | 84.9 (45) |
Micrographia | 5.1 (42) | 5.5 (219) | 8.7 (336) | 16.2 (454) | 27.9 (17) | 9.3 (1068) | <0.0001 | 73.6 (39) |
Smell less acute | 7.7 (63) | 7.9 (315) | 9.3 (357) | 11.4 (319) | 13.1 (8) | 9.2 (1062) | <0.0001 | 34.0 (18) |
Any of symptoms | 25.7 (210) | 32.6 (1306) | 46.1 (1775) | 65.1 (1826) | 77.1 (47) | 44.8 (5164) | <0.0001 | 96.2 (51) |
Self-reported PD | 0.12 (1) | 0.35 (14) | 0.36 (14) | 0.82 (23) | 1.64 (1) | 0.46 (53) | 0.0012 | Â |
Including Missing answers as a separate category | ||||||||
Symptom | 40–49 (1342) | 50–59 (6341) | 60–69 (6063) | 70–79 (4608) | 80+ (111) | All Ages (18 465) | P- value for age trend* | PD Cases (69) |
Resting Tremor | ||||||||
   Yes | 3.5 (47) | 3.2 (203) | 3.7 (224) | 4.5 (206) | 6.3 (7) | 3.7 (687) | 0.0026 | 42.0 (29) |
   No | 84.8 (1138) | 87.1 (5526) | 88.8 (5385) | 87.9 (4052) | 83.8 (93) | 87.7 (16194) |  | 50.7 (35) |
   Missing | 11.7 (157) | 9.7 (612) | 7.5 (454) | 7.6 (350) | 9.9 (11) | 8.6 (1584) |  | 7.3 (5) |
Difficulty Walking | ||||||||
   Yes | 3.4 (46) | 4.7 (295) | 3.4 (208) | 3.4 (157) | 6.3 (7) | 3.9 (713) | 0.0042 | 33.3 (23) |
   No | 68.6 (921) | 71.5 (4537) | 76.4 (4630) | 75.2 (3464) | 72.1 (80) | 73.8 (13632) |  | 59.4 (41) |
   Missing | 28.0 (375) | 23.8 (1509) | 20.2 (1225) | 21.4 (987) | 21.6 (24) | 22.3 (4120) |  | 7.3 (5) |
Difficulty Chair | ||||||||
   Yes | 5.3 (71) | 5.6 (354) | 5.2 (312) | 6.1 (279) | 6.3 (7) | 5.5 (1023) | 0.6787 | 37.7 (26) |
   No | 66.5 (892) | 69.5 (4405) | 72.9 (4421) | 71.2 (3281) | 68.5 (76) | 70.8 (13075) |  | 58.0 (40) |
   Missing | 28.2 (379) | 24.9 (1582) | 21.9 (1330) | 22.7 (1048) | 25.2 (28) | 23.7 (4367) |  | 4.3 (3) |
Walking Slower | ||||||||
   Yes | 8.4 (113) | 16.1 (1024) | 29.5 (1787) | 47.0 (2165) | 55.9 (62) | 27.9 (5151) | <0.0001 | 82.6 (57) |
   No | 61.0 (818) | 56.7 (3594) | 47.2 (2862) | 30.7 (1417) | 18.0 (20) | 47.2 (8711) |  | 14.5 (10) |
   Missing | 30.6 (411) | 27.2 (1723) | 23.3 (1414) | 22.3 (1026) | 26.1 (29) | 24.9 (4603) |  | 2.9 (2) |
Micrographia | ||||||||
   Yes | 4.6 (62) | 4.6 (294) | 7.4 (446) | 13.1 (604) | 21.6 (24) | 7.7 (1430) | <0.0001 | 71.0 (49) |
   No | 65.2 (875) | 69.5 (4406) | 70.6 (4283) | 65.4 (3012) | 54.1 (60) | 68.5 (12636) |  | 24.6 (17) |
   Missing | 30.2 (405) | 25.9 (1641) | 22.0 (1334) | 21.5 (992) | 24.3 (27) | 23.8 (4399) |  | 4.4 (3) |
Smell less acute | ||||||||
   Yes | 5.4 (73) | 6.1 (388) | 7.4 (450) | 8.8 (407) | 10.8 (12) | 7.2 (1330) | <0.0001 | 30.4 (21) |
   No | 61.5 (825) | 66.2 (4199) | 68.7 (4164) | 68.9 (3175) | 65. 8 (73) | 67.4 (12436) |  | 56.5 (39) |
   Missing | 33.1 (444) | 27.7 (1754) | 23.9 (1449) | 22.3 (1026) | 23.4 (26) | 25.4 (4699) |  | 13.1 (9) |
Any of symptoms | ||||||||
   Yes | 15.7 (210) | 20.6 (1306) | 29.3 (1775) | 39.6 (1826) | 42.3 (47) | 28.0 (5164) | <0.0001 | 73.9 (51) |
   No | 45.3 (608) | 42.6 (2702) | 34.2 (2074) | 21.2 (977) | 12.6 (14) | 34.5 (6375) |  | 2.9 (2) |
   Missing | 39.0 (524) | 36.8 (2333) | 36.5 (2214) | 39.2 (1805) | 45. 1 (50) | 37.5 (6926) |  | 23.2 (16) |
Self-reported PD | 0.07 (1) | 0.25 (16) | 0.31 (19) | 0.69 (32) | 0.90 (1) | 0.37 (69) | <0.0001 | Â |