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Table 4 Multilinear regression (general linear model; GLM) analysis of the cohort 2 CFS – associated proteome. Proteins that were detected significantly more frequently in CFS than HC were shown in column 2. The significance (P), explained variance (R2), and probabilities for the association of each protein when stratified by CFS status, gender, and their cross-product were tabulated. The presence of at least 1 of the 5 CFS proteome proteins (right justified and bold italics) was sufficient to identify all the CFS subjects in Cohort 2 (B 1/5 ; see Results). (n.s., not significant).

From: A chronic fatigue syndrome – related proteome in human cerebrospinal fluid

  Cohort 2: Multilinear Analysis (GLM; individual samples)
GeneID Cohort 2 CFS Proteome P R2 CFS Gender CFS × Gender
3868 Keratin 16 (B 1/5 ) 0.0001 1 0.0001 0.0001 0.0001
2 α2-Macroglobulin (B 1/5 ) 0.001 0.63 0.009 0.023 0.003
1356 Ceruloplasmin 0.001 0.63 0.009 0.023 0.003
5005 Orosomucoid 2 (B 1/5 ) 0.001 0.63 0.009 0.023 0.003
5168 Autotaxin (B 1/5 ) 0.001 0.63 0.009 0.023 0.003
351 APLP1 0.001 0.63 0.009 0.023 0.003
63827 BEHAB 0.001 0.63 0.009 0.023 0.003
140446 Keratin 6C 0.001 0.63 0.009 0.023 0.003
3872 Keratin 17 0.001 0.63 0.009 0.023 0.003
5004 Orosomucoid 1 0.001 0.63 0.009 0.023 0.003
3858 Keratin 10 0.013 0.48 n.s. 0.016 n.s.
721 C4B 0.022 0.44 0.007 n.s. n.s.
5176 PEDF (B 1/5 ) 0.022 0.44 0.007 n.s. n.s.
2934 Gelsolin 0.033 0.41 n.s. n.s. 0.011
84735 CNDP 1 0.037 0.40 n.s. 0.033 n.s.
3861 Keratin 14 0.037 0.40 n.s. 0.033 n.s.